DACT3-AS1

Summary

DACT3-AS1 (DACT3 antisense RNA 1, HGNC:44120) is a long non-coding RNA gene on chromosome 19q13.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44120
Approved symbol	DACT3-AS1
Name	DACT3 antisense RNA 1
Location	19q13.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245598
Ensembl biotype	lncRNA
Entrez	100506068
RNAcentral	URS000075C334 — lncRNA, 1320 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000500689, ENST00000525008, ENST00000525352, ENST00000690000, ENST00000692220, ENST00000754480, ENST00000754481, ENST00000754482, ENST00000754483, ENST00000754484, ENST00000754485, ENST00000754486

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500689 — 3 exons

Exon	Start	End
ENSE00001746672	46671141	46671341
ENSE00001974930	46669168	46669310
ENSE00001991771	46661478	46662437

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 83.43.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2689 / max 194.1457, expressed in 52 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176598	0.2504	47
176599	0.0185	4

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.43	gold quality
right testis	UBERON:0004534	76.79	gold quality
left testis	UBERON:0004533	75.95	gold quality
cortical plate	UBERON:0005343	73.47	gold quality
right coronary artery	UBERON:0001625	73.32	gold quality
testis	UBERON:0000473	73.14	gold quality
popliteal artery	UBERON:0002250	73.06	gold quality
tibial artery	UBERON:0007610	73.04	gold quality
descending thoracic aorta	UBERON:0002345	72.88	gold quality
aorta	UBERON:0000947	72.55	gold quality
thoracic aorta	UBERON:0001515	72.31	gold quality
ascending aorta	UBERON:0001496	72.17	gold quality
sperm	CL:0000019	70.22	silver quality
sural nerve	UBERON:0015488	69.87	gold quality
left coronary artery	UBERON:0001626	68.33	gold quality
ganglionic eminence	UBERON:0004023	67.53	gold quality
coronary artery	UBERON:0001621	67.20	gold quality
stromal cell of endometrium	CL:0002255	66.84	gold quality
anterior cingulate cortex	UBERON:0009835	64.56	gold quality
apex of heart	UBERON:0002098	64.51	gold quality
body of uterus	UBERON:0009853	64.44	gold quality
prefrontal cortex	UBERON:0000451	64.43	gold quality
smooth muscle tissue	UBERON:0001135	64.25	gold quality
granulocyte	CL:0000094	64.08	gold quality
ventricular zone	UBERON:0003053	63.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.78	gold quality
nucleus accumbens	UBERON:0001882	62.77	gold quality
right frontal lobe	UBERON:0002810	62.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Hypoxia-induced LncRNA DACT3-AS1 upregulates PKM2 to promote metastasis in hepatocellular carcinoma through the HDAC2/FOXA3 pathway. (PMID:35764883)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.