DANCR

Summary

DANCR (differentiation antagonizing non-protein coding RNA, HGNC:28964) is a long non-coding RNA gene on chromosome 4q12.

This gene produces a long non-coding RNA that functions as a negative regulator of cell differentiation. This transcript associates with enhancer of zeste homolog 2 to repress expression of the runt related transcription factor 2 gene. Increased expression of this transcript may be associated with cancer. Alternatively spliced transcript variants have been observed.

Source: NCBI Gene 57291 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28964
Approved symbol	DANCR
Name	differentiation antagonizing non-protein coding RNA
Location	4q12
Locus type	RNA, long non-coding
Status	Approved
Aliases	ANCR, AGU2, lncRNA-ANCR
Ensembl gene	ENSG00000226950
Ensembl biotype	lncRNA
OMIM	614625
Entrez	57291
RNAcentral	URS0000ABD85C — lncRNA, 915 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000411630, ENST00000425653, ENST00000441504, ENST00000444958, ENST00000623036, ENST00000653147, ENST00000675191, ENST00000675590, ENST00000675705, ENST00000675988, ENST00000676012, ENST00000676199, ENST00000676262, ENST00000676450

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411630 — 3 exons

Exon	Start	End
ENSE00001622615	52712824	52712959
ENSE00003899391	52712325	52712527
ENSE00003903732	52713494	52714141

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 98.68.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 63.2090 / max 1000.7311, expressed in 1800 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47611	45.6545	1786
47610	17.5545	1755

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	98.68	gold quality
left ovary	UBERON:0002119	98.49	gold quality
cortical plate	UBERON:0005343	98.07	gold quality
body of pancreas	UBERON:0001150	98.02	gold quality
ovary	UBERON:0000992	97.98	gold quality
right ovary	UBERON:0002118	97.85	gold quality
heart left ventricle	UBERON:0002084	97.58	gold quality
apex of heart	UBERON:0002098	97.54	gold quality
metanephros cortex	UBERON:0010533	97.52	gold quality
cortex of kidney	UBERON:0001225	97.37	gold quality
lower esophagus mucosa	UBERON:0035834	97.05	gold quality
right adrenal gland	UBERON:0001233	97.04	gold quality
pancreas	UBERON:0001264	96.97	gold quality
mucosa of transverse colon	UBERON:0004991	96.90	gold quality
right adrenal gland cortex	UBERON:0035827	96.82	gold quality
adult mammalian kidney	UBERON:0000082	96.77	gold quality
heart	UBERON:0000948	96.74	gold quality
esophagus mucosa	UBERON:0002469	96.74	gold quality
body of stomach	UBERON:0001161	96.72	gold quality
left adrenal gland cortex	UBERON:0035825	96.72	gold quality
left adrenal gland	UBERON:0001234	96.69	gold quality
caudate nucleus	UBERON:0001873	96.56	gold quality
fundus of stomach	UBERON:0001160	96.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.42	gold quality
nucleus accumbens	UBERON:0001882	96.36	gold quality
ventricular zone	UBERON:0003053	96.34	gold quality
saliva-secreting gland	UBERON:0001044	96.22	gold quality
minor salivary gland	UBERON:0001830	96.20	gold quality
putamen	UBERON:0001874	96.20	gold quality
islet of Langerhans	UBERON:0000006	96.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• ANCR lncRNA is thus required to enforce the undifferentiated cell state within epidermis (PMID:22302877)
• These data suggest that ANCR is an essential mediator of osteoblast differentiation. (PMID:23438432)
• Significant upregulation of long non-coding RNA-DANCR in circulating monocytes in the postmenopausal osteoporosis patients. (PMID:25660720)
• Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR (PMID:26514989)
• Our data indicated that lncRNA DANCR expression might be a novel potential biomarker for colorectal cancer prognosis. (PMID:26617879)
• High ANCR long noncoding RNA expression is associated with Osteosarcoma. (PMID:26986815)
• Knockdown of ANCR induced an epithelial-mesenchymal transition program and promoted cell migration and invasion in MCF10A, whereas ectopic expression of ANCR repressed breast cancer cells migration and invasion. (PMID:27716745)
• This study revealed, for the first time, the importance of DANCR in clinical diagnosis and disease progression of HCC (PMID:27919960)
• according to the results of this study,DANCR is dramatically upregulated in Gastric cancer tissues and the high expression of DANCR is significantly associated with worse overall survival in Gastric cancer patients (PMID:28618943)
• results suggest that DANCR is a crucial upregulator of osteosarcoma and an independent predictor of prognosis. DANCR increases cancer stem cells function by upregulating AXL via competitively binding to miR-33a-5p, and this function is sequentially performed through the PI3K-Akt signaling pathway. (PMID:28642170)
• results characterized miR-1305-Smad4 axis as a major downstream functional mechanism of lncRNA DANCR in promoting the chondrogenesis in synovium-derived mesenchymal stem cells. (PMID:28674107)
• inhibited the cell proliferation, migration, and invasion of osteosarcoma cells, possibly through interacting with EZH2 and regulating the expression of p21 and p27 (PMID:28679390)
• DANCR was found to mediate the proliferation and osteogenic differentiation of HBMSCs via p38 MAPK inactivation, but not via extracellular signal-regulated protein kinase (ERK)1/2 or c-Jun N-terminal kinase (JNK) MAPKs, but. (PMID:29115577)
• DANCR is a critical lncRNA widely overexpressed in human cancers.MYC directly regulates DANCR. (PMID:29180471)
• Long non-coding RNA DANCR contributes to lung adenocarcinoma progression by sponging miR-496 to modulate mTOR expression. (PMID:29266795)
• he present study demonstrated that DANCR/miR-634/RAB1A axis plays crucial roles in the progression of glioma, and DANCR might potentially serve as a therapeutic target for the treatment of glioma patients. (PMID:29301870)
• LncRNA DANCR could inhibit osteoblast differentiation by regulating FOXO1 expression. (PMID:29338713)
• DANCR promotes cisplatin resistance via activating AXL/PI3K/Akt/NF-kappaB signaling pathway in glioma. (PMID:29572052)
• DANCR positively affected glioma progression via activating Wnt/beta-catenin signaling pathway. (PMID:29602127)
• DANCR promotes non-small cell lung cancer cell proliferation, migration and invasion by regulating the tumor suppressor miR-758-3p. (PMID:29635134)
• DANCR upregulation was seen in lung cancer, particularly in high-grade lung cancer tissues and aggressive cancer cells. Ectopic DANCR expression induced lung cancer cell proliferation and colony formation, whereas DANCR silencing induced opposing effects. (PMID:29651883)
• the study revealed that lncRNA DANCR might promote the proliferation of osteoarthritis chondrocytes and reduce apoptosis through the miR-577/SphK2 axis. (PMID:29678573)
• DANCR promoted HSP27 expression and its mediation of proliferation/metastasis via miR-577 sponging. (PMID:29717105)
• Long non-coding RNAs-DANCR likely serves as a useful disease biomarker or therapeutic cancer target. (PMID:29728310)
• Data indicate that miR-758 is the direct target of long noncoding RNAs (lncRNAs) ANCR. (PMID:29913147)
• knockdown of DANCR increased the expression of miR-33a-5p, reduced Epithelial-Mesenchymal Transition, and increased apoptosis in glioma (PMID:29940760)
• DANCR promoted the proliferation, inflammation, and reduced cell apoptosis in osteoarthritis chondrocytes through regulating miR-216a-5p/JAK2/STAT3 signaling pathway. (PMID:30361290)
• DANCR promotes cervical cancer progression by functioning as a competing endogenous RNA (ceRNA) to regulate ROCK1 expression via sponging miR-335-5. (PMID:30362591)
• Authors found that DANCR was distributed mostly in the cytoplasm and DANCR functioned as a miRNA sponge to positively regulate the expression of musashi RNA binding protein 2 (MSI2) through sponging miR-149 and subsequently promoted malignant phenotypes of bladder cancer cells, thus playing an oncogenic role in bladder cancer pathogenesis. (PMID:30419948)
• DANCR also strongly suppressed hepatocellular carcinoma tumor growth in vivo via targeting miR-216a-5p and KLF12. (PMID:30430564)
• Long non-coding RNA DANCR upregulates PIK3CA/AKT signaling through activating serine phosphorylation of RXRA. (PMID:30518934)
• lncRNA DANCR was upregulated in lung adenocarcinoma (LAD) tissue and cell lines, compared with paratumor tissue and a normal lung cell line. Additionally, elevated DANCR expression was associated with poor prognosis in the patients with LAD. In LAD cell lines DANCR promoted the invasion of lung adenocarcinoma cells by positively regulating HMGA2. (PMID:30535487)
• Taken together, these results suggest that DANCR acts as a prognostic biomarker and increases HIF-1alpha mRNA stability by interacting with NF90/NF45, leading to metastasis and disease progression of nasopharyngeal carcinoma. (PMID:30555573)
• lnc-DANCR-mediated miR-665 downregulation regulates the malignant phenotype of CC cells. (PMID:30582654)
• lncRNA DANCR was upregulated in NPC cells. DANCR promoted cell proliferation and migration, and inhibited apoptosis in NPC cells. Mechanistically, DANCR regulated the levels of p-AKT, PTEN, BAX and BCL2 in NPC cells. (PMID:30720067)
• The present study demonstrates that DANCR, acting as an oncogene promotes nasopharyngeal carcinoma progression. (PMID:30849642)
• The present study demonstrated that DANCR was associated with papillary thyroid cancer (PTC) aggressive clinical features and may serve as a diagnostic biomarker for detecting PTC patients. (PMID:30910839)
• DANCR might act as a tumor promoter by targetting miRNA-216a-5p, which might provide a potential therapy target for breast cancer treatment. (PMID:30910842)
• LncRNA DANCR accelerates the development of multidrug resistance of gastric cancer. (PMID:31002130)
• DANCR acted as a ceRNA to decoy miR-27a-3p. (PMID:31038266)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.