DAOA-AS1

Summary

DAOA-AS1 (DAOA antisense RNA 1, HGNC:30243) is a long non-coding RNA gene on chromosome 13q33.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30243
Approved symbol	DAOA-AS1
Name	DAOA antisense RNA 1
Location	13q33.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	G30
Ensembl gene	ENSG00000232307
Ensembl biotype	lncRNA
OMIM	607415
Entrez	282706
RNAcentral	URS00004EDADC — lncRNA, 2482 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000448407

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000448407 — 7 exons

Exon	Start	End
ENSE00001614824	105505582	105505681
ENSE00001626819	105492060	105492177
ENSE00001633550	105491107	105491151
ENSE00001650102	105462299	105462507
ENSE00001711776	105466187	105466420
ENSE00001721578	105459055	105460588
ENSE00001754061	105489776	105490017

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 79.59.

Top tissues by expression

166 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	79.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	46.78	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
heart left ventricle	UBERON:0002084	41.97	gold quality
middle temporal gyrus	UBERON:0002771	41.49	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality
vagina	UBERON:0000996	41.37	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
prefrontal cortex	UBERON:0000451	41.35	gold quality
adult mammalian kidney	UBERON:0000082	41.34	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
cardiac ventricle	UBERON:0002082	41.15	gold quality
bone marrow	UBERON:0002371	41.14	gold quality
skeletal muscle tissue	UBERON:0001134	41.10	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
heart	UBERON:0000948	40.89	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
nasal cavity mucosa	UBERON:0001826	40.63	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
endometrium	UBERON:0001295	40.57	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
adipose tissue	UBERON:0001013	40.50	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
adrenal gland	UBERON:0002369	40.43	gold quality
kidney	UBERON:0002113	40.38	gold quality
adipose tissue of abdominal region	UBERON:0007808	40.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes (PMID:12647258)
• identified statistically significant differences in allele distributions of two markers rs3916965 and rs2391191, and a highly significant association between haplotype AGAC of the G72/G30 locus and schizophrenia in the Chinese population (PMID:15194506)
• the G30 region is involved in susceptibility to schizophrenia in the Ashkenazi population. (PMID:15271585)
• Results suggest that variability of the DAOA/G30 locus may be involved in the etiology of panic disorder. (PMID:15477870)
• Identifies LTR class mobile element sequences at the G72/G30 locus. (PMID:15546984)
• this gene implicated in schizophrenia among Chinese population. (PMID:15653269)
• This study failed to find evidence for an association for schizophrenia with single nucleotide polymorphisms at the G72/G30 locus. (PMID:15738936)
• A statistically significant association was found between rs778293 and schizophrenia in Asian populations, but not European populations. (PMID:16402132)
• The G72/G30 gene may be implicated in susceptibility to schizophrenia and there may be an interaction between this gene and sex in the pathogenesis of schizophrenia. (PMID:16791105)
• The results suggest that there is weak evidence of association between the G72/G30 genes and schizophrenia. (PMID:17179078)
• These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia. (PMID:17179866)
• Association of polymorphism with schizophrenia not consistent with those found in other populations, and may be chance findings. (PMID:17651942)
• Some support for the individual involvement of DAO and G72(DAOA)/G30 in the etiology of bipolar disorder. (PMID:18165970)
• The G72/G30 complex is considered as one of the most promising candidate genes for both schizophrenia and bipolar disorder. (PMID:18775646)
• The transgenic mice which expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to psychiatric disorders. (PMID:19189879)
• A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A. (PMID:19937977)
• study reports G72/G30 expression profiles and behavioral changes in a G72/G30 transgenic mouse model; the transcriptome profile changes and multiple mouse behavioral effects suggest that the G72 gene may play a role in modulating behaviors relevant to psychiatric disorders (PMID:23337943)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.