DARS1-AS1

Summary

DARS1-AS1 (DARS1 antisense RNA 1, HGNC:40170) is a long non-coding RNA gene on chromosome 2q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40170
Approved symbol	DARS1-AS1
Name	DARS1 antisense RNA 1
Location	2q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231890
Ensembl biotype	lncRNA
Entrez	101928243
RNAcentral	URS000075A539 — lncRNA, 881 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 76 — 76 lncRNA

ENST00000399447, ENST00000419808, ENST00000438432, ENST00000444406, ENST00000444649, ENST00000446492, ENST00000448672, ENST00000593405, ENST00000593462, ENST00000594219, ENST00000594735, ENST00000595061, ENST00000595624, ENST00000596410, ENST00000597450, ENST00000598565, ENST00000599018, ENST00000599279, ENST00000601196, ENST00000601586, ENST00000607985, ENST00000608471, ENST00000609237, ENST00000609663, ENST00000613688, ENST00000615163, ENST00000625389, ENST00000627442, ENST00000627657, ENST00000629483, ENST00000631306, ENST00000669983, ENST00000692958, ENST00000701667, ENST00000702825, ENST00000717303, ENST00000764009, ENST00000764010, ENST00000764011, ENST00000764012, ENST00000764013, ENST00000764014, ENST00000764015, ENST00000764016, ENST00000764017, ENST00000764018, ENST00000764019, ENST00000764020, ENST00000764021, ENST00000764022, ENST00000764023, ENST00000764024, ENST00000764025, ENST00000764026, ENST00000764027, ENST00000764028, ENST00000764029, ENST00000764030, ENST00000764031, ENST00000764032, ENST00000764033, ENST00000764034, ENST00000764035, ENST00000764036, ENST00000764037, ENST00000764038, ENST00000764039, ENST00000764040, ENST00000764041, ENST00000764042, ENST00000764043, ENST00000764044, ENST00000764045, ENST00000764046, ENST00000764047, ENST00000764048

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000399447 — 6 exons

Exon	Start	End
ENSE00001609356	136000413	136000479
ENSE00001656601	136008867	136009073
ENSE00001769542	136007196	136007583
ENSE00003204540	136014656	136014762
ENSE00003216473	136012850	136012982
ENSE00003772465	136016458	136016517

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 84.11.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.2784 / max 55.9687, expressed in 1095 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22673	1.1960	660
22672	0.9159	560
22674	0.1665	40

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	84.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.24	gold quality
bone marrow cell	CL:0002092	77.11	gold quality
granulocyte	CL:0000094	76.44	gold quality
colonic epithelium	UBERON:0000397	75.82	gold quality
right lobe of liver	UBERON:0001114	75.38	gold quality
esophagus mucosa	UBERON:0002469	74.74	gold quality
right uterine tube	UBERON:0001302	74.58	gold quality
sural nerve	UBERON:0015488	74.09	gold quality
leukocyte	CL:0000738	73.38	gold quality
monocyte	CL:0000576	73.28	gold quality
adrenal tissue	UBERON:0018303	72.62	gold quality
right adrenal gland cortex	UBERON:0035827	72.14	gold quality
left testis	UBERON:0004533	72.08	gold quality
right testis	UBERON:0004534	72.07	gold quality
right lobe of thyroid gland	UBERON:0001119	71.99	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.88	gold quality
right adrenal gland	UBERON:0001233	71.78	gold quality
skin of abdomen	UBERON:0001416	71.49	gold quality
left lobe of thyroid gland	UBERON:0001120	70.77	gold quality
blood	UBERON:0000178	70.63	gold quality
left adrenal gland cortex	UBERON:0035825	70.34	gold quality
testis	UBERON:0000473	70.29	gold quality
skin of leg	UBERON:0001511	70.24	gold quality
left adrenal gland	UBERON:0001234	70.12	gold quality
thyroid gland	UBERON:0002046	69.87	gold quality
adenohypophysis	UBERON:0002196	69.82	gold quality
body of pancreas	UBERON:0001150	69.63	gold quality
spleen	UBERON:0002106	69.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Long non-coding RNA DARS-AS1 promotes tumorigenesis of non-small cell lung cancer via targeting miR-532-3p. (PMID:31317683)
• LncRNA DARS-AS1 regulates microRNA-129 to promote malignant progression of thyroid cancer. (PMID:31841198)
• DARS-AS1 promotes clear cell renal cell carcinoma by sequestering miR-194-5p to up-regulate DARS. (PMID:32526457)
• Oncogenic Long Noncoding RNA DARS-AS1 in Childhood Acute Myeloid Leukemia by Binding to microRNA-425. (PMID:33073700)
• DARS-AS1 Knockdown Inhibits the Growth of Cervical Cancer Cells via Downregulating HMGB1 via Sponging miR-188-5p. (PMID:33176595)
• Upregulation of lncRNA DARS-AS1 accelerates tumor malignancy in cervical cancer by activating cGMP-PKG pathway. (PMID:33634536)
• Long noncoding RNA DARS-AS1 regulates TP53 ubiquitination and affects ovarian cancer progression by modulation miR-194-5p/RBX1 axis. (PMID:34328246)
• LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis. (PMID:34596006)
• Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis. (PMID:34644678)
• lncRNA DARS-AS1 Promoted Osteosarcoma Progression through Regulating miR-532-3p/CCR7. (PMID:35422889)
• DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m(6)A modification and translation for cytoprotective autophagy in cervical cancer. (PMID:35638109)
• Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. (PMID:37540752)
• Silencing lncRNA-DARS-AS1 suppresses nonsmall cell lung cancer progression by stimulating miR-302a-3p to inhibit ACAT1 expression. (PMID:38289172)
• DARS-AS1: A Vital Oncogenic LncRNA Regulator with Potential for Cancer Prognosis and Therapy. (PMID:38322590)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.