DBET

Summary

DBET (D4Z4 binding element transcript, HGNC:43904) is a long non-coding RNA gene on chromosome 4q35.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43904
Approved symbol	DBET
Name	D4Z4 binding element transcript
Location	4q35.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	DBE-T, DUX4L30
Ensembl gene	ENSG00000281591
Ensembl biotype	lncRNA
OMIM	614865
Entrez	100419743
RNAcentral	URS000075D547 — lncRNA, 3363 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000630918

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000630918 — 1 exons

Exon	Start	End
ENSE00003766689	190064502	190067864

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 76.82.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.82	gold quality
sural nerve	UBERON:0015488	72.13	gold quality
liver	UBERON:0002107	59.97	gold quality
pancreas	UBERON:0001264	59.38	gold quality
monocyte	CL:0000576	59.22	gold quality
ganglionic eminence	UBERON:0004023	56.26	silver quality
cortex of kidney	UBERON:0001225	55.00	gold quality
blood	UBERON:0000178	54.08	gold quality
stromal cell of endometrium	CL:0002255	52.94	silver quality
urinary bladder	UBERON:0001255	52.14	silver quality
lymph node	UBERON:0000029	49.80	silver quality
tibial nerve	UBERON:0001323	47.43	gold quality
muscle of leg	UBERON:0001383	46.93	gold quality
gastrocnemius	UBERON:0001388	46.65	gold quality
endometrium	UBERON:0001295	46.58	gold quality
heart left ventricle	UBERON:0002084	46.18	gold quality
superior frontal gyrus	UBERON:0002661	45.36	silver quality
adult mammalian kidney	UBERON:0000082	45.27	silver quality
prefrontal cortex	UBERON:0000451	45.22	silver quality
frontal cortex	UBERON:0001870	45.18	gold quality
heart	UBERON:0000948	45.15	gold quality
tibial artery	UBERON:0007610	44.95	gold quality
prostate gland	UBERON:0002367	44.81	gold quality
cerebellum	UBERON:0002037	44.16	silver quality
right frontal lobe	UBERON:0002810	44.01	gold quality
esophagus mucosa	UBERON:0002469	43.30	gold quality
cerebellar cortex	UBERON:0002129	42.95	silver quality
multicellular organism	UBERON:0000468	42.93	gold quality
subcutaneous adipose tissue	UBERON:0002190	42.86	gold quality
anterior cingulate cortex	UBERON:0009835	42.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study identifies DBE-T, a chromatin-associated noncoding RNA produced selectively in FSHD patients that coordinates de-repression of 4q35 genes; DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation (PMID:22541069)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.