DBH-AS1

Summary

DBH-AS1 (DBH antisense RNA 1, HGNC:24155) is a long non-coding RNA gene on chromosome 9q34.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24155
Approved symbol	DBH-AS1
Name	DBH antisense RNA 1
Location	9q34.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	BPR
Ensembl gene	ENSG00000225756
Ensembl biotype	lncRNA
Entrez	138948
RNAcentral	URS00000AF948 — lncRNA, 2139 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000425189

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425189 — 2 exons

Exon	Start	End
ENSE00001668866	133654586	133656537
ENSE00001721239	133657127	133657313

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 96.80.

Top tissues by expression

225 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	96.80	gold quality
right lobe of liver	UBERON:0001114	95.07	gold quality
cauda epididymis	UBERON:0004360	88.50	gold quality
liver	UBERON:0002107	87.86	gold quality
pancreatic ductal cell	CL:0002079	87.76	silver quality
upper arm skin	UBERON:0004263	82.17	gold quality
kidney epithelium	UBERON:0004819	78.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.81	silver quality
epithelial cell of pancreas	CL:0000083	77.74	gold quality
body of pancreas	UBERON:0001150	77.37	gold quality
pituitary gland	UBERON:0000007	76.00	gold quality
adenohypophysis	UBERON:0002196	74.99	gold quality
caput epididymis	UBERON:0004358	73.70	gold quality
lymph node	UBERON:0000029	73.28	gold quality
cortex of kidney	UBERON:0001225	73.24	gold quality
right adrenal gland	UBERON:0001233	73.03	gold quality
metanephros cortex	UBERON:0010533	72.86	gold quality
endothelial cell	CL:0000115	72.78	silver quality
thymus	UBERON:0002370	72.66	gold quality
kidney	UBERON:0002113	72.13	gold quality
adult mammalian kidney	UBERON:0000082	72.00	gold quality
left adrenal gland cortex	UBERON:0035825	71.84	gold quality
layer of synovial tissue	UBERON:0007616	71.81	silver quality
left adrenal gland	UBERON:0001234	71.75	gold quality
adrenal cortex	UBERON:0001235	71.52	gold quality
granulocyte	CL:0000094	71.36	gold quality
right adrenal gland cortex	UBERON:0035827	71.31	gold quality
adrenal gland	UBERON:0002369	71.25	gold quality
vena cava	UBERON:0004087	71.17	silver quality
cerebellar vermis	UBERON:0004720	71.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• DBH-AS1 can be induced by HBx and inactivated by p53, and consequently promote cell proliferation and cell survival through activation of MAPK signaling in hepatocellular carcinoma (PMID:26393879)
• DBH-AS1 facilitated the development of hepatocellular carcinoma via miR-138/FAK/Src/ERK pathway. (PMID:30142544)
• Knockdown of DBH-AS1 inhibited cell proliferation, migration and invasion, while promoted apoptosis in osteosarcoma. Moreover, suppression of DBH-AS1 could inhibit the activation of the PI3K/Akt pathway, which was demonstrated by examining the expression levels of p-PI3K and p-Akt. (PMID:30840262)
• Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13. (PMID:32091157)
• LncRNA DBH-AS1 facilitates the tumorigenesis of melanoma by targeting miR-233-3p via IGF-1R/Akt signaling. (PMID:32744696)
• LncDBH-AS1 knockdown enhances proliferation of non-small cell lung cancer cells by activating the Wnt signaling pathway via the miR-155/AXIN1 axis. (PMID:33506901)
• Paclitaxel-resistant related lncRNA DBH-AS1 promotes the proliferation and invasion of esophageal cancer. (PMID:36524510)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.