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DCAF11

gene
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Also known as PRO2389GL014

Summary

DCAF11 (DDB1 and CUL4 associated factor 11, HGNC:20258) is a protein-coding gene on chromosome 14q12, encoding DDB1- and CUL4-associated factor 11 (Q8TEB1). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene.

Source: NCBI Gene 80344 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 96 total
  • Druggable target: yes
  • MANE Select transcript: NM_025230

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:20258
Approved symbolDCAF11
NameDDB1 and CUL4 associated factor 11
Location14q12
Locus typegene with protein product
StatusApproved
AliasesPRO2389, GL014
Ensembl geneENSG00000100897
Ensembl biotypeprotein_coding
OMIM613317
Entrez80344

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 40 protein_coding, 8 nonsense_mediated_decay, 5 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000326009, ENST00000396936, ENST00000396941, ENST00000446197, ENST00000557802, ENST00000557809, ENST00000557810, ENST00000557888, ENST00000557952, ENST00000558215, ENST00000558408, ENST00000558624, ENST00000558638, ENST00000558706, ENST00000558914, ENST00000559017, ENST00000559115, ENST00000559144, ENST00000559288, ENST00000559354, ENST00000559382, ENST00000559396, ENST00000559451, ENST00000559472, ENST00000559593, ENST00000559796, ENST00000560046, ENST00000560171, ENST00000560457, ENST00000560459, ENST00000560614, ENST00000560713, ENST00000560901, ENST00000561001, ENST00000561016, ENST00000561041, ENST00000561056, ENST00000561375, ENST00000905287, ENST00000905288, ENST00000905289, ENST00000905290, ENST00000905291, ENST00000905292, ENST00000905293, ENST00000905294, ENST00000905295, ENST00000905296, ENST00000905297, ENST00000905298, ENST00000933294, ENST00000933295, ENST00000942877, ENST00000942878, ENST00000942879, ENST00000942880

RefSeq mRNA: 3 — MANE Select: NM_025230 NM_001163484, NM_025230, NM_181357

CCDS: CCDS41929, CCDS9610

Canonical transcript exons

ENST00000446197 — 15 exons

ExonStartEnd
ENSE000025592862412317524125242
ENSE000034649302411805524118155
ENSE000034764732412297124123077
ENSE000034797182411726624117393
ENSE000035403532411766824117732
ENSE000035432802411971124119896
ENSE000035764132411875024118804
ENSE000035797842412083824120991
ENSE000036309482411914524119213
ENSE000036349412411838824118534
ENSE000036431172411955924119616
ENSE000036452822411691724117044
ENSE000036470742411538224115749
ENSE000036747882412136524121517
ENSE000039031842411477724115293

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 97.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.1331 / max 553.1543, expressed in 1820 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
13897615.54131812
1389786.18401758
1389793.5636754
1389770.8443503

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
right lobe of liverUBERON:000111497.52gold quality
liverUBERON:000210797.43gold quality
duodenumUBERON:000211497.28gold quality
body of pancreasUBERON:000115096.81gold quality
sural nerveUBERON:001548896.33gold quality
skeletal muscle tissueUBERON:000113496.05gold quality
pancreasUBERON:000126495.98gold quality
bloodUBERON:000017895.89gold quality
granulocyteCL:000009495.56gold quality
muscle of legUBERON:000138395.55gold quality
bone marrowUBERON:000237195.46gold quality
gastrocnemiusUBERON:000138895.38gold quality
right adrenal glandUBERON:000123395.13gold quality
right adrenal gland cortexUBERON:003582795.06gold quality
hindlimb stylopod muscleUBERON:000425295.01gold quality
left adrenal glandUBERON:000123494.89gold quality
adrenal glandUBERON:000236994.75gold quality
muscle tissueUBERON:000238594.73gold quality
adult mammalian kidneyUBERON:000008294.69gold quality
tonsilUBERON:000237294.66gold quality
left adrenal gland cortexUBERON:003582594.66gold quality
bone marrow cellCL:000209294.62gold quality
prefrontal cortexUBERON:000045194.57gold quality
rectumUBERON:000105294.48gold quality
frontal cortexUBERON:000187094.31gold quality
islet of LangerhansUBERON:000000694.24gold quality
gall bladderUBERON:000211094.19gold quality
apex of heartUBERON:000209894.14gold quality
heart left ventricleUBERON:000208494.12gold quality
lymph nodeUBERON:000002994.00gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-CURD-112yes45.22
E-ANND-3yes6.15
E-MTAB-6379no388.76

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

50 targeting DCAF11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-188-3P100.0068.761240
HSA-MIR-4776-3P100.0068.731340
HSA-MIR-4455100.0065.481587
HSA-MIR-4795-3P100.0074.624024
HSA-MIR-185-3P99.9567.011743
HSA-MIR-9983-3P99.9471.483631
HSA-MIR-129-5P99.8870.263273
HSA-MIR-3663-3P99.8470.39798
HSA-MIR-465899.7764.94514
HSA-MIR-6790-5P99.7765.24505
HSA-MIR-4524A-3P99.7266.852406
HSA-MIR-472999.6972.184233
HSA-MIR-317599.6566.302031
HSA-MIR-182799.6368.573265
HSA-MIR-24-3P99.5969.971934
HSA-MIR-6832-5P99.5864.821132
HSA-MIR-54399.5269.032595
HSA-MIR-4708-3P99.5167.99870
HSA-MIR-6727-3P99.4965.921333
HSA-MIR-19A-5P99.3666.931675
HSA-MIR-3064-5P99.2666.131497
HSA-MIR-3085-3P99.2666.161490
HSA-MIR-6504-5P99.2665.951487
HSA-MIR-4685-5P99.2565.991563
HSA-MIR-6837-5P99.2565.471632
HSA-MIR-3922-3P99.2564.961136
HSA-MIR-7160-5P99.1167.172207
HSA-MIR-7151-3P99.0469.722370
HSA-MIR-6749-3P99.0065.731443
HSA-MIR-6760-5P98.8766.731515

Literature-anchored findings (GeneRIF, showing 9)

  • Includes the functional characterization of a similar protein in C. elegans and comparison to the human protein. (PMID:19273594)
  • CRL4(WDR23) is required for efficient histone mRNA 3’ end processing to produce mature histone mRNAs for translation. CRL4(WDR23) binds and ubiquitylates SLBP in vitro and in vivo, and this modification activates SLBP function in histone mRNA 3’ end processing without affecting its protein levels. (PMID:27203182)
  • CRL4-DCAF11 mediates the degradation of SLBP at the end of S phase and this degradation is essential for the viability of cells. (PMID:27254819)
  • Here, the authors demonstrated that CUL4B forms an E3 ligase with RBX1 (RING-box 1), DDB1 (DNA damage binding protein 1), and DCAF11 (DDB1 and CUL4 associated factor 11) that promotes the ubiquitination of p21(Cip1) and regulates cell cycle progression in human osteosarcoma cells. (PMID:28446751)
  • ur results identify WDR23 as an alternative regulator of NRF2 proteostasis and uncover a cellular pathway that regulates NRF2 activity and capacity for cytoprotection independently of KEAP1. (PMID:28453520)
  • results support a model in which the activation of the TNF-alpha/NF-kappaB axis contributes to an increase in CRL4B(DCAF)(11) activity and a decrease in p21(Cip1) protein levels, thereby controlling cell cycle progression in human osteosarcoma cells. (PMID:29377600)
  • TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62. (PMID:31586112)
  • WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes. (PMID:32839090)
  • DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. (PMID:33783207)

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_reriodcaf11ENSDARG00000009868
mus_musculusDcaf11ENSMUSG00000022214
rattus_norvegicusDcaf11ENSRNOG00000018825
drosophila_melanogasterCG9945FBGN0034527
caenorhabditis_eleganswdr-23WBGENE00008419

Protein

Protein identifiers

DDB1- and CUL4-associated factor 11 — Q8TEB1 (reviewed: Q8TEB1)

Alternative names: WD repeat-containing protein 23

All UniProt accessions (22): Q8TEB1, H0YKR8, H0YL29, H0YL64, H0YL98, H0YLB2, H0YLF1, H0YLH4, H0YLQ1, H0YLX7, H0YM56, H0YM86, H0YMF7, H0YMN6, H0YMZ4, H0YN03, H0YN15, H0YN21, H0YN92, H0YNK2, H0YNS2, H0YNT0

UniProt curated annotations — full annotation on UniProt →

Function. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Subunit / interactions. Interacts with DDB1 and CUL4A.

Pathway. Protein modification; protein ubiquitination.

Isoforms (3)

UniProt IDNamesCanonical?
Q8TEB1-11yes
Q8TEB1-22
Q8TEB1-33

RefSeq proteins (3): NP_001156956, NP_079506, NP_852002 (=MANE)

Domains & families (InterPro)

IDNameType
IPR001680WD40_rptRepeat
IPR015943WD40/YVTN_repeat-like_dom_sfHomologous_superfamily
IPR017399DCAF11/LEC14BFamily
IPR020472WD40_PAC1Repeat
IPR036322WD40_repeat_dom_sfHomologous_superfamily
IPR051859DCAFFamily

Pfam: PF00400

UniProt features (20 total): repeat 7, sequence conflict 3, compositionally biased region 2, modified residue 2, splice variant 2, region of interest 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8TEB1-F183.300.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 75, 49

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-8951664Neddylation

MSigDB gene sets: 214 (showing top): GOBP_MITOTIC_CYTOKINESIS, GOBP_MEMORY, GOBP_RESPIRATORY_GASEOUS_EXCHANGE_BY_RESPIRATORY_SYSTEM, GOBP_COGNITION, GOBP_BEHAVIOR, GNF2_PRDX2, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_RESPIRATORY_SYSTEM_PROCESS, FOXO4_01, chr14q12, GNF2_ANK1, EVI1_05, GATA3_01, GOBP_CYTOKINESIS

GO Biological Process (9): respiratory system process (GO:0003016), response to oxidative stress (GO:0006979), memory (GO:0007613), gene expression (GO:0010467), protein ubiquitination (GO:0016567), exploration behavior (GO:0035640), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161), protein stabilization (GO:0050821), cognition (GO:0050890)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): nucleoplasm (GO:0005654), Cul4-RING E3 ubiquitin ligase complex (GO:0080008)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Post-translational protein modification1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
system process1
respiratory gaseous exchange by respiratory system1
response to stress1
learning or memory1
macromolecule biosynthetic process1
protein modification by small protein conjugation1
behavior1
ubiquitin-dependent protein catabolic process1
proteasomal protein catabolic process1
regulation of protein stability1
nervous system process1
binding1
nuclear lumen1
cellular anatomical structure1
cullin-RING ubiquitin ligase complex1

Protein interactions and networks

STRING

981 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
DCAF11DDB1Q16531997
DCAF11POU2F3Q9UKI9940
DCAF11CUL4AQ13619938
DCAF11CUL4BQ13620811
DCAF11NKRFO15226693
DCAF11RBX1P62877678
DCAF11NEIL2Q969S2635
DCAF11GSTM2P28161572
DCAF11CUL3Q13618495
DCAF11KEAP1Q14145491
DCAF11DCAF1Q9Y4B6487
DCAF11HHATQ5VTY9472
DCAF11DCAF4Q8WV16470
DCAF11DCAF12Q5T6F0467
DCAF11DCAF8Q5TAQ9467

IntAct

112 interactions, top by confidence:

ABTypeScore
NEDD8UBE2Mpsi-mi:“MI:0914”(association)0.940
COPS2GPS1psi-mi:“MI:0914”(association)0.860
COPS8COPS2psi-mi:“MI:0914”(association)0.850
CUL4BCOPS2psi-mi:“MI:0914”(association)0.790
DCAF11DDB1psi-mi:“MI:0407”(direct interaction)0.760
COPS6RHOBTB1psi-mi:“MI:0914”(association)0.730
B3GNT3PGRMC1psi-mi:“MI:0914”(association)0.670
CUL4ACOPS2psi-mi:“MI:0914”(association)0.640
ARL4CRGS12psi-mi:“MI:0914”(association)0.640
DCAF11RCN1psi-mi:“MI:0915”(physical association)0.560
DCAF11TNNI2psi-mi:“MI:0915”(physical association)0.560
RCN1DCAF11psi-mi:“MI:0915”(physical association)0.560
AGR2DCAF11psi-mi:“MI:0915”(physical association)0.560
TNNI2DCAF11psi-mi:“MI:0915”(physical association)0.560

BioGRID (447): DDB1 (Affinity Capture-Western), CUL4A (Affinity Capture-Western), CUL4B (Affinity Capture-Western), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Two-hybrid), DCAF11 (Reconstituted Complex), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Affinity Capture-MS), DCAF11 (Reconstituted Complex)

ESM2 similar proteins: A2AKB9, A2RRH5, A2RRU4, A2SXS5, A6QM06, O60346, O88559, P30291, P97260, Q08BB3, Q0P5I0, Q12770, Q3B7L5, Q3MHH0, Q3UHE1, Q4R3J7, Q5E9I8, Q5FW06, Q5M9G8, Q5MNU5, Q5QP82, Q5R7H5, Q5T6F0, Q5VW00, Q5ZJL7, Q63ZP7, Q69Z89, Q6AX81, Q6GQT6, Q6NS60, Q6NWH1, Q6P809, Q6ZWB6, Q8AVS9, Q8BGW4, Q8BGZ3, Q8CHE4, Q8NHY2, Q8QZS3, Q8TEB1

Diamond homologs: A8XEN7, O24467, O94394, P41318, P90794, Q1JQD2, Q40153, Q5E9I8, Q5M9G8, Q5R7H5, Q5XI13, Q6FLI3, Q7S8R5, Q810D6, Q8TEB1, Q91VU6, O14435, O14775, O43071, O45040, P17343, P23232, P26308, P40968, Q08706, Q54KL5, Q5GIS3, Q5RDY7, Q61ZF6, Q6DRF9, Q6PNB6, Q80ZD0, Q9LFE2, Q9SY00, A0A1W5T363, A5GFN6, A8WGF4, B5DG67, C5PFX0, G0SEA3

SIGNOR signaling

2 interactions.

AEffectBMechanism
DCAF11“down-regulates quantity by destabilization”GEN1binding
DCAF11“up-regulates activity”Cullin4-RBX1-DDB1binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 103 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
DNA Damage Recognition in GG-NER1248.9×2e-15
Formation of TC-NER Pre-Incision Complex1133.2×3e-12
Cargo recognition for clathrin-mediated endocytosis913.5×2e-06
Neddylation1610.8×1e-10

GO biological processes:

GO termPartnersFoldFDR
regulation of protein neddylation883.2×5e-12
protein neddylation970.2×1e-12
cellular response to UV516.4×2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

96 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance74
Likely benign1
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2214 predictions. Top by Δscore:

VariantEffectΔscore
14:24117254:T:TAacceptor_gain1.0000
14:24117264:A:AGacceptor_gain1.0000
14:24117264:AGT:Aacceptor_gain1.0000
14:24117264:AGTG:Aacceptor_gain1.0000
14:24117265:G:GGacceptor_gain1.0000
14:24117265:GT:Gacceptor_gain1.0000
14:24117265:GTG:Gacceptor_gain1.0000
14:24117265:GTGG:Gacceptor_gain1.0000
14:24117265:GTGGA:Gacceptor_gain1.0000
14:24118378:A:AGacceptor_gain1.0000
14:24118382:A:AGacceptor_gain1.0000
14:24118383:C:Gacceptor_gain1.0000
14:24118383:CACA:Cacceptor_loss1.0000
14:24118384:A:AGacceptor_gain1.0000
14:24118385:C:Gacceptor_gain1.0000
14:24118386:A:AGacceptor_gain1.0000
14:24118386:A:Cacceptor_loss1.0000
14:24118387:G:GAacceptor_gain1.0000
14:24118387:GA:Gacceptor_gain1.0000
14:24118387:GAC:Gacceptor_gain1.0000
14:24118387:GACC:Gacceptor_gain1.0000
14:24118387:GACCA:Gacceptor_gain1.0000
14:24118530:TTACA:Tdonor_gain1.0000
14:24118531:TACA:Tdonor_gain1.0000
14:24118532:ACA:Adonor_gain1.0000
14:24118533:CA:Cdonor_gain1.0000
14:24118534:AG:Adonor_loss1.0000
14:24118535:G:Cdonor_loss1.0000
14:24118535:GTGA:Gdonor_gain1.0000
14:24118539:G:GGdonor_gain1.0000

AlphaMissense

3587 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
14:24118104:T:CF176L1.000
14:24118106:C:AF176L1.000
14:24118106:C:GF176L1.000
14:24118400:G:CR197P1.000
14:24118465:T:AW219R1.000
14:24118465:T:CW219R1.000
14:24118467:G:CW219C1.000
14:24118467:G:TW219C1.000
14:24118468:A:CS220R1.000
14:24118470:C:AS220R1.000
14:24118470:C:GS220R1.000
14:24118472:T:AV221D1.000
14:24118519:A:CS237R1.000
14:24118521:C:AS237R1.000
14:24118521:C:GS237R1.000
14:24118522:T:AW238R1.000
14:24118522:T:CW238R1.000
14:24119170:T:CF269L1.000
14:24119172:C:AF269L1.000
14:24119172:C:GF269L1.000
14:24119737:T:AN311K1.000
14:24119737:T:GN311K1.000
14:24119780:G:TG326W1.000
14:24119781:G:AG326E1.000
14:24119787:A:CD328A1.000
14:24119787:A:TD328V1.000
14:24119807:T:AW335R1.000
14:24119807:T:CW335R1.000
14:24120860:C:TS372F1.000
14:24120864:C:AN373K1.000

dbSNP variants (sampled 300 via entrez): RS1000079743 (14:24116661 T>C,G), RS1000139909 (14:24113970 G>T), RS1000679395 (14:24118027 C>A,G,T), RS1000748812 (14:24124871 A>G), RS1000951440 (14:24124560 C>G), RS1000955429 (14:24116453 C>T), RS1001157784 (14:24122786 A>G), RS1001221193 (14:24123701 G>A), RS1002182016 (14:24115003 A>C,G), RS1002324166 (14:24121295 A>C), RS1002463611 (14:24116700 G>C), RS1002923296 (14:24114148 G>A,C), RS1003217224 (14:24116060 G>A,T), RS1003536574 (14:24120135 G>A), RS1003595601 (14:24116370 C>A)

Disease associations

OMIM: gene MIM:613317 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5465399 (PROTEIN-PROTEIN INTERACTION)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Ozoneaffects cotreatment, decreases expression, increases abundance, affects expression3
methacrylaldehydeaffects cotreatment, decreases expression, increases abundance2
Acroleinaffects cotreatment, decreases expression, increases abundance2
Air Pollutantsdecreases expression, increases abundance, affects expression, affects cotreatment2
Hydrogen Peroxideaffects expression2
Silicon Dioxidedecreases expression2
aristolochic acid Idecreases expression1
methyleugenoldecreases expression1
triphenyl phosphateaffects expression1
alpha-pineneaffects cotreatment, decreases expression, increases abundance1
pirinixic acidincreases activity, affects binding, decreases expression1
beta-lapachoneincreases expression, decreases expression1
benzo(e)pyrenedecreases methylation1
CGP 52608affects binding, increases reaction1
perfluoro-n-nonanoic aciddecreases expression1
ON 01910increases expression1
(+)-JQ1 compounddecreases expression1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acidincreases expression1
Bortezomibdecreases expression1
Acetaminophendecreases expression1
Benzo(a)pyrenedecreases expression1
Caffeineincreases phosphorylation1
Estradiolincreases expression1
Ivermectindecreases expression1
Methapyrilenedecreases methylation1
Cyclosporinedecreases expression1
Aflatoxin B1affects expression1
Cadmium Chlorideincreases expression1
Okadaic Aciddecreases expression1
Copper Sulfateincreases expression1

ChEMBL screening assays

26 unique, capped per target: 26 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5369322BindingPROTAC activity at DCAF11/BRD4 in HEK293T cells assessed as reduction of protein degradation at 1 uM measured after 24 hrs relative to controlUnlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative Approaches. — J Med Chem

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_D7NEUbigene A-549 DCAF11 KOCancer cell lineMale
CVCL_D9CZUbigene HEK293 DCAF11 KOTransformed cell lineFemale
CVCL_E1V9HAP1 DCAF11 (-)Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
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Sources 78

This page pulls from 78 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot