DCAF4

Summary

DCAF4 (DDB1 and CUL4 associated factor 4, HGNC:20229) is a protein-coding gene on chromosome 14q24.2, encoding DDB1- and CUL4-associated factor 4 (Q8WV16). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene.

Source: NCBI Gene 26094 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 123 total
• MANE Select transcript: NM_015604

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20229
Approved symbol	DCAF4
Name	DDB1 and CUL4 associated factor 4
Location	14q24.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp434K114
Ensembl gene	ENSG00000119599
Ensembl biotype	protein_coding
OMIM	616372
Entrez	26094

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 13 protein_coding, 5 protein_coding_CDS_not_defined, 3 retained_intron, 1 nonsense_mediated_decay

ENST00000353777, ENST00000358377, ENST00000394234, ENST00000505361, ENST00000508412, ENST00000509153, ENST00000509320, ENST00000510612, ENST00000513337, ENST00000514191, ENST00000514486, ENST00000553457, ENST00000555042, ENST00000555992, ENST00000557203, ENST00000850844, ENST00000850845, ENST00000892932, ENST00000892933, ENST00000892934, ENST00000892935, ENST00000943130

RefSeq mRNA: 8 — MANE Select: NM_015604 NM_001163508, NM_001163509, NM_001352447, NM_001352448, NM_001352449, NM_015604, NM_181340, NM_181341

CCDS: CCDS41968, CCDS55926, CCDS9809, CCDS9810

Canonical transcript exons

ENST00000358377 — 14 exons

Exon	Start	End
ENSE00001097298	72945884	72946027
ENSE00001154214	72954164	72954262
ENSE00002043252	72958612	72959703
ENSE00003471259	72939802	72939902
ENSE00003489962	72947142	72947191
ENSE00003496111	72941745	72941824
ENSE00003520618	72940220	72940377
ENSE00003545682	72956386	72956500
ENSE00003554218	72955523	72955696
ENSE00003597331	72951798	72951877
ENSE00003597666	72954386	72954483
ENSE00003618620	72942994	72943096
ENSE00003684628	72937971	72938070
ENSE00004282476	72926464	72926543

Expression profiles

Bgee: expression breadth ubiquitous, 219 present calls, max score 88.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.1875 / max 155.1186, expressed in 1770 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140490	11.2167	1769
140491	0.8817	462
140492	0.0613	27
140493	0.0278	14

Top tissues by expression

269 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.45	gold quality
skin of leg	UBERON:0001511	87.06	gold quality
left lobe of thyroid gland	UBERON:0001120	86.83	gold quality
skin of abdomen	UBERON:0001416	86.76	gold quality
body of pancreas	UBERON:0001150	86.70	gold quality
right lobe of thyroid gland	UBERON:0001119	86.47	gold quality
thyroid gland	UBERON:0002046	86.25	gold quality
right coronary artery	UBERON:0001625	85.37	gold quality
cortical plate	UBERON:0005343	85.11	gold quality
gastrocnemius	UBERON:0001388	84.82	gold quality
mucosa of transverse colon	UBERON:0004991	84.82	gold quality
left ovary	UBERON:0002119	84.76	gold quality
right ovary	UBERON:0002118	84.53	gold quality
right adrenal gland cortex	UBERON:0035827	84.47	gold quality
zone of skin	UBERON:0000014	84.33	gold quality
popliteal artery	UBERON:0002250	84.26	gold quality
tibial artery	UBERON:0007610	84.24	gold quality
pons	UBERON:0000988	84.12	silver quality
muscle of leg	UBERON:0001383	83.91	gold quality
metanephros cortex	UBERON:0010533	83.45	gold quality
aorta	UBERON:0000947	83.42	gold quality
sural nerve	UBERON:0015488	83.40	gold quality
right adrenal gland	UBERON:0001233	83.18	gold quality
ovary	UBERON:0000992	83.04	gold quality
calcaneal tendon	UBERON:0003701	82.63	gold quality
ascending aorta	UBERON:0001496	82.60	gold quality
adrenal cortex	UBERON:0001235	82.50	gold quality
middle temporal gyrus	UBERON:0002771	82.49	gold quality
ectocervix	UBERON:0012249	82.49	gold quality
pancreas	UBERON:0001264	82.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

27 targeting DCAF4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-3158-5P	99.65	67.51	1763
HSA-MIR-302B-5P	99.50	69.49	1857
HSA-MIR-302D-5P	99.50	69.34	1863
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-5683	99.36	68.59	2083
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-6719-3P	99.29	67.78	1387
HSA-MIR-4477B	99.23	70.49	1733
HSA-MIR-8077	99.17	66.67	862
HSA-MIR-4763-3P	99.10	67.83	2649
HSA-MIR-4650-3P	99.01	68.39	1062
HSA-MIR-3124-3P	98.87	68.95	2123
HSA-MIR-4451	98.82	68.17	1455
HSA-MIR-1261	98.62	68.10	896
HSA-MIR-224-5P	98.33	70.12	1256
HSA-MIR-93-3P	98.15	66.65	1309
HSA-MIR-432-5P	98.00	68.13	989
HSA-MIR-6865-3P	97.54	64.67	684
HSA-MIR-1910-5P	97.42	66.36	844
HSA-MIR-6816-3P	95.05	66.08	459

Literature-anchored findings (GeneRIF, showing 3)

• The minor allele of WDR21A may induce a good response to inhaled corticosteroids possibly through competition with the Gbeta(1) proteins for binding to GRs (PMID:22366774)
• Genome-wide association (GWA) meta-analysis and de novo genotyping of 20 022 individuals revealed a novel association (p=6.4x10(-10)) between LTL and rs2535913, which lies within DCAF4 (PMID:25624462)
• our results suggest that rs12587742 is associated with an increased lung cancer risk, possibly by up-regulating mRNA expression and decreasing methylation status of DCAF4. (PMID:28383684)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Dcaf4	ENSMUSG00000021222
rattus_norvegicus	Dcaf4	ENSRNOG00000008399

Paralogs (26): PAFAH1B1 (ENSG00000007168), SNRNP40 (ENSG00000060688), WDR62 (ENSG00000075702), WDR7 (ENSG00000091157), TBL2 (ENSG00000106638), PAK1IP1 (ENSG00000111845), WDR75 (ENSG00000115368), DAW1 (ENSG00000123977), TEP1 (ENSG00000129566), AHI1 (ENSG00000135541), WDR38 (ENSG00000136918), MAPKBP1 (ENSG00000137802), POC1B (ENSG00000139323), NEDD1 (ENSG00000139350), COP1 (ENSG00000143207), WDR17 (ENSG00000150627), WDR43 (ENSG00000163811), POC1A (ENSG00000164087), WDR88 (ENSG00000166359), WDR81 (ENSG00000167716), DCAF4L2 (ENSG00000176566), DCAF4L1 (ENSG00000182308), WDR27 (ENSG00000184465), NWD1 (ENSG00000188039), WDR5 (ENSG00000196363), WDR5B (ENSG00000196981)

Protein

Protein identifiers

DDB1- and CUL4-associated factor 4 — Q8WV16 (reviewed: Q8WV16)

Alternative names: WD repeat-containing protein 21A

All UniProt accessions (4): Q8WV16, D6RCB5, G3V3D6, Q86SY2

UniProt curated annotations — full annotation on UniProt →

Function. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Subunit / interactions. Interacts with DDB1 and CUL4A.

Pathway. Protein modification; protein ubiquitination.

Polymorphism. An intronic G-to-A transition (rs2535913) has been associated with leukocyte telomere length. The minor A allele is associated with shorter telomeres and lower expression in lymphoblastoid cells and in sun-exposed skin.

Isoforms (5)

UniProt ID	Names	Canonical?
Q8WV16-1	1	yes
Q8WV16-2	2
Q8WV16-3	3
Q8WV16-4	4
Q8WV16-5	5

RefSeq proteins (8): NP_001156980, NP_001156981, NP_001339376, NP_001339377, NP_001339378, NP_056419, NP_851937, NP_851938 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR052254	CUL4-DDB1_E3_ligase_receptor	Family

Pfam: PF23761

UniProt features (24 total): splice variant 6, sequence variant 6, sequence conflict 4, compositionally biased region 3, repeat 2, chain 1, helix 1, region of interest 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3I8C	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WV16-F1	77.34	0.34

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8951664	Neddylation

MSigDB gene sets: 128 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, MORF_ZNF10, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, chr14q24, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, MORF_EPHA7, MORF_IL9, MORF_DCC, GOCC_TRANSFERASE_COMPLEX, GAL_LEUKEMIC_STEM_CELL_UP, SANSOM_APC_TARGETS, GOCC_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX, GOCC_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX

GO Biological Process (1): protein ubiquitination (GO:0016567)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): nucleoplasm (GO:0005654), Cul4-RING E3 ubiquitin ligase complex (GO:0080008)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein modification by small protein conjugation	1
binding	1
nuclear lumen	1
cellular anatomical structure	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

496 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DCAF4	DDB1	Q16531	845
DCAF4	DCAF12	Q5T6F0	610
DCAF4	ZNF208	O43345	576
DCAF4	DCAF5	Q96JK2	574
DCAF4	ZNF676	Q8N7Q3	571
DCAF4	DCAF8	Q5TAQ9	552
DCAF4	RBX1	P62877	551
DCAF4	DCAF6	Q58WW2	551
DCAF4	ST7	Q9NRC1	527
DCAF4	DDB2	Q92466	524
DCAF4	DCAF10	Q5QP82	509
DCAF4	ACYP2	P14621	507
DCAF4	CUL4A	Q13619	471
DCAF4	DCAF11	Q8TEB1	470
DCAF4	LRRIQ4	A6NIV6	464

IntAct

99 interactions, top by confidence:

A	B	Type	Score
NOP10	DKC1	psi-mi:“MI:0914”(association)	0.890
COPS2	GPS1	psi-mi:“MI:0914”(association)	0.860
COPS8	COPS2	psi-mi:“MI:0914”(association)	0.850
CUL4B	RBX1	psi-mi:“MI:0914”(association)	0.820
DDB1	DCAF4	psi-mi:“MI:0407”(direct interaction)	0.790
CUL4B	COPS2	psi-mi:“MI:0914”(association)	0.790
DCAF4	DDB1	psi-mi:“MI:0915”(physical association)	0.790
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
DKC1	SHQ1	psi-mi:“MI:0914”(association)	0.670
PFDN2	POLR3A	psi-mi:“MI:0914”(association)	0.670
CUL4A	COPS2	psi-mi:“MI:0914”(association)	0.640
NEUROG3	GXYLT2	psi-mi:“MI:0914”(association)	0.640
CUL4A	RBX1	psi-mi:“MI:0914”(association)	0.640
POLR2F	POLR3A	psi-mi:“MI:0914”(association)	0.640
GLMN	FKBP5	psi-mi:“MI:0914”(association)	0.640
CCT3	TXNDC9	psi-mi:“MI:0914”(association)	0.640

BioGRID (578): DDB1 (Affinity Capture-Western), CUL4A (Affinity Capture-Western), CUL4B (Affinity Capture-Western), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS), DCAF4 (Affinity Capture-MS)

ESM2 similar proteins: A0A140LI67, A0A1W2PR48, A0JP70, D3YYM4, F1LW30, O13034, O15040, O70173, Q15345, Q3SXM0, Q3UDP0, Q3UJB9, Q3ULW6, Q3V129, Q3ZAV8, Q58DC2, Q5F479, Q5JV73, Q5M9H0, Q5M9H1, Q5R6T6, Q5R9H2, Q68DX3, Q6IRN0, Q6NV72, Q6P2E9, Q6P4K6, Q6PCD5, Q6ZPG2, Q6ZW76, Q7TNH6, Q80TQ5, Q8BLD6, Q8C008, Q8C5V5, Q8CBW4, Q8CIK8, Q8IWE5, Q8JZL1, Q8K1C9

Diamond homologs: Q3SXM0, Q58DC2, Q8NA75, Q8WV16, Q8RXA7

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
DCAF4	“up-regulates activity”	OPTN	binding
DCAF4	“up-regulates activity”	Cullin4-RBX1-DDB1	binding
DCAF4	“down-regulates quantity by destabilization”	ST7	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 93 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
DNA Damage Recognition in GG-NER	11	50.6×	1e-14
Formation of TC-NER Pre-Incision Complex	12	40.9×	1e-14
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	5	21.4×	2e-04
Gap-filling DNA repair synthesis and ligation in TC-NER	5	14.4×	8e-04
Dual incision in TC-NER	5	13.9×	8e-04
Cargo recognition for clathrin-mediated endocytosis	7	11.8×	1e-04
Peptide chain elongation	5	10.2×	3e-03
Viral mRNA Translation	5	10.2×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
regulation of protein neddylation	7	76.2×	3e-10
protein neddylation	8	65.3×	5e-11
cytoplasmic translation	5	10.8×	6e-03
protein folding	7	8.4×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

123 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	90
Likely benign	16
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2305 predictions. Top by Δscore:

Variant	Effect	Δscore
14:72926542:AGGTA:A	donor_loss	1.0000
14:72926543:GGTA:G	donor_loss	1.0000
14:72926544:G:GG	donor_gain	1.0000
14:72926545:T:A	donor_loss	1.0000
14:72937969:A:AC	acceptor_loss	1.0000
14:72937969:A:AG	acceptor_gain	1.0000
14:72937969:AG:A	acceptor_gain	1.0000
14:72937970:G:GC	acceptor_gain	1.0000
14:72937970:GG:G	acceptor_gain	1.0000
14:72937970:GGAAC:G	acceptor_gain	1.0000
14:72939800:A:G	acceptor_loss	1.0000
14:72939899:CCAGG:C	donor_loss	1.0000
14:72939900:CAGGT:C	donor_loss	1.0000
14:72939901:AGGTA:A	donor_loss	1.0000
14:72939902:GGT:G	donor_loss	1.0000
14:72940216:A:AG	acceptor_gain	1.0000
14:72940217:A:G	acceptor_gain	1.0000
14:72940218:A:AG	acceptor_gain	1.0000
14:72940219:G:GG	acceptor_gain	1.0000
14:72940219:GA:G	acceptor_gain	1.0000
14:72940239:T:TA	acceptor_gain	1.0000
14:72940245:T:TA	acceptor_gain	1.0000
14:72940275:T:TA	acceptor_gain	1.0000
14:72940276:G:A	acceptor_gain	1.0000
14:72940357:G:GT	donor_gain	1.0000
14:72940374:AAAGG:A	donor_loss	1.0000
14:72940375:AAGG:A	donor_loss	1.0000
14:72940376:AGGT:A	donor_loss	1.0000
14:72940377:GGTGG:G	donor_loss	1.0000
14:72940378:G:GG	donor_gain	1.0000

AlphaMissense

3237 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:72954256:A:C	S301R	0.999
14:72954258:T:A	S301R	0.999
14:72954258:T:G	S301R	0.999
14:72947157:T:A	W232R	0.998
14:72947157:T:C	W232R	0.998
14:72947191:T:C	L243P	0.998
14:72954223:T:A	W290R	0.998
14:72954223:T:C	W290R	0.998
14:72940261:T:C	F79L	0.997
14:72940263:C:A	F79L	0.997
14:72940263:C:G	F79L	0.997
14:72945909:T:C	F187S	0.997
14:72951842:T:C	L258P	0.997
14:72940231:T:C	F69L	0.996
14:72940233:T:A	F69L	0.996
14:72940233:T:G	F69L	0.996
14:72954254:T:C	F300S	0.996
14:72940262:T:C	F79S	0.995
14:72947159:G:C	W232C	0.995
14:72947159:G:T	W232C	0.995
14:72947161:C:A	A233D	0.995
14:72940258:T:G	Y78D	0.994
14:72951800:T:C	L244P	0.994
14:72951842:T:A	L258Q	0.994
14:72954193:T:C	F280L	0.994
14:72954195:C:A	F280L	0.994
14:72954195:C:G	F280L	0.994
14:72954262:G:C	G303R	0.994
14:72956395:T:A	W397R	0.994
14:72956395:T:C	W397R	0.994

dbSNP variants (sampled 300 via entrez): RS1000087640 (14:72928368 T>C), RS1000176647 (14:72945525 T>C), RS1000226251 (14:72929849 G>A,T), RS1000291259 (14:72945164 A>C), RS1000363284 (14:72958336 G>A), RS1000390370 (14:72951551 C>T), RS1000403818 (14:72937224 G>GA), RS1000462549 (14:72931871 G>A), RS1000465598 (14:72924983 C>T), RS1000555627 (14:72931502 C>A,T), RS1000618491 (14:72953419 A>G), RS1000678723 (14:72951714 C>T), RS1000786590 (14:72926084 A>G), RS1000815839 (14:72935277 C>T), RS1000922417 (14:72930004 T>C)

Disease associations

OMIM: gene MIM:616372 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST005863_29	Menopause (age at onset)	1.000000e-08
GCST005863_33	Menopause (age at onset)	3.000000e-08
GCST006814_6	End-stage renal disease	2.000000e-06
GCST008366_22	Leukocyte telomere length	9.000000e-09
GCST009391_1990	Metabolite levels	8.000000e-06
GCST009856_9	Leukocyte telomere length	2.000000e-08
GCST010002_156	Refractive error	7.000000e-25
GCST90002381_603	Eosinophil count	4.000000e-13
GCST90002382_226	Eosinophil percentage of white cells	4.000000e-15
GCST90002397_366	Mean spheric corpuscular volume	2.000000e-10
GCST90002405_372	Reticulocyte count	3.000000e-10

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004704	age at menopause
EFO:0005058	tyrosine measurement
EFO:0004842	eosinophil count
EFO:0007991	eosinophil percentage of leukocytes
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs7160796	Efficacy	3	corticosteroids	Asthma

PharmGKB variants

3 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs3213729	DCAF4		0.00	0
rs7142086	DCAF4		0.00	0
rs7160796	DCAF4	3	2.00	1	corticosteroids

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	8
trichostatin A	affects cotreatment, increases expression	3
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Cyclosporine	increases expression	2
Cadmium Chloride	decreases expression	2
manganese chloride	increases abundance, increases expression, affects cotreatment	1
benzo(e)pyrene	increases methylation	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Coumestrol	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Gallic Acid	decreases expression	1
Hydrogen Peroxide	affects expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Methapyrilene	increases methylation	1
Smoke	decreases expression	1
Thimerosal	decreases expression	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1LC	HyCyte HT-29 KO-hDCAF4	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.