DCLRE1A

Summary

DCLRE1A (DNA cross-link repair 1A, HGNC:17660) is a protein-coding gene on chromosome 10q25.3, encoding DNA cross-link repair 1A protein (Q6PJP8). May be required for DNA interstrand cross-link repair.

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 9937 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 159 total
• Druggable target: yes
• MANE Select transcript: NM_014881

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17660
Approved symbol	DCLRE1A
Name	DNA cross-link repair 1A
Location	10q25.3
Locus type	gene with protein product
Status	Approved
Aliases	SNM1, PSO2, KIAA0086, hSNM1
Ensembl gene	ENSG00000198924
Ensembl biotype	protein_coding
OMIM	609682
Entrez	9937

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000361384, ENST00000369305, ENST00000476112, ENST00000852021

RefSeq mRNA: 2 — MANE Select: NM_014881 NM_001271816, NM_014881

CCDS: CCDS7584

Canonical transcript exons

ENST00000361384 — 9 exons

Exon	Start	End
ENSE00000986810	113848980	113850644
ENSE00000986812	113847202	113847335
ENSE00000986813	113845685	113845803
ENSE00000986814	113844104	113844244
ENSE00000986815	113842343	113842488
ENSE00000986816	113841406	113841560
ENSE00000986817	113837062	113837203
ENSE00001123928	113852723	113854082
ENSE00003751580	113834725	113835312

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 99.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.1754 / max 84.5843, expressed in 1015 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111462	2.0405	986
111461	0.1349	51

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.12	gold quality
oocyte	CL:0000023	97.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.33	gold quality
ventricular zone	UBERON:0003053	83.29	gold quality
ganglionic eminence	UBERON:0004023	82.20	gold quality
tendon of biceps brachii	UBERON:0008188	82.11	silver quality
hair follicle	UBERON:0002073	81.85	gold quality
islet of Langerhans	UBERON:0000006	81.19	gold quality
germinal epithelium of ovary	UBERON:0001304	80.19	silver quality
epithelium of nasopharynx	UBERON:0001951	79.41	silver quality
cortical plate	UBERON:0005343	79.31	gold quality
embryo	UBERON:0000922	78.07	gold quality
pancreas	UBERON:0001264	76.72	gold quality
mononuclear cell	CL:0000842	76.53	gold quality
monocyte	CL:0000576	76.52	gold quality
leukocyte	CL:0000738	76.36	gold quality
rectum	UBERON:0001052	76.26	gold quality
body of pancreas	UBERON:0001150	76.02	gold quality
prefrontal cortex	UBERON:0000451	75.25	gold quality
right adrenal gland cortex	UBERON:0035827	74.87	gold quality
right adrenal gland	UBERON:0001233	74.35	gold quality
colonic epithelium	UBERON:0000397	73.88	gold quality
right lobe of liver	UBERON:0001114	73.76	gold quality
pigmented layer of retina	UBERON:0001782	73.75	gold quality
adrenal tissue	UBERON:0018303	73.64	gold quality
left adrenal gland	UBERON:0001234	73.62	gold quality
tendon	UBERON:0000043	73.48	gold quality
gastrocnemius	UBERON:0001388	73.22	gold quality
bone marrow cell	CL:0002092	73.10	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	49.03
E-ANND-3	no	2.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting DCLRE1A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-155-5P	99.35	70.16	1509
HSA-MIR-4641	99.28	66.64	744
HSA-MIR-133A-3P	99.27	71.53	1270
HSA-MIR-133B	99.27	71.53	1270
HSA-MIR-642A-3P	99.23	67.67	1258
HSA-MIR-642B-3P	99.23	67.67	1258
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-548L	99.06	70.90	2560
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-501-5P	98.77	68.88	1328
HSA-MIR-500A-5P	98.76	69.13	1241
HSA-MIR-606	98.72	67.34	960
HSA-MIR-6881-3P	98.04	68.24	1777
HSA-MIR-3977	98.00	68.17	1500
HSA-MIR-362-5P	95.87	66.02	554
HSA-MIR-500B-5P	95.87	66.04	557
HSA-MIR-598-3P	89.25	67.61	112

Literature-anchored findings (GeneRIF, showing 15)

• Results suggest that 53BP1 and Snm1 may cooperate in the cellular response to genotoxic damage. (PMID:12446782)
• Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation (PMID:15542852)
• The SNM1 enzyme utilizes either DNA or RNA substrates, requires a 5’-phosphate moiety, shows very little activity on double-strand substrates, and functions at a size consistent with a monomer. (PMID:17804464)
• Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. (PMID:18006388)
• hSNM1 appears to represent a second pathway for genome stability (PMID:18180189)
• These findings suggest that SNM1A acts with ATM to promote the G1 cell cycle checkpoint. (PMID:18848520)
• RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger (PMID:20385554)
• collaboration between hSNM1A and XPF-ERCC1 is necessary to initiate interstrand cross-link repair in replicating human cells (PMID:21896658)
• differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles (PMID:22692201)
• Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B. (PMID:26582912)
• Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5’-3’ exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction. (PMID:28607004)
• Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink. (PMID:30165656)
• The SNM1A DNA repair nuclease. (PMID:32866775)
• Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. (PMID:34387696)
• SNM1A is crucial for efficient repair of complex DNA breaks in human cells. (PMID:38918391)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dclre1a	ENSDARG00000091768
mus_musculus	Dclre1a	ENSMUSG00000025077
rattus_norvegicus	Dclre1a	ENSRNOG00000026204
drosophila_melanogaster	Snm1	FBGN0037338

Paralogs (2): DCLRE1B (ENSG00000118655), DCLRE1C (ENSG00000152457)

Protein

Protein identifiers

DNA cross-link repair 1A protein — Q6PJP8 (reviewed: Q6PJP8)

Alternative names: Beta-lactamase DCLRE1A, SNM1 homolog A

All UniProt accessions (1): Q6PJP8

UniProt curated annotations — full annotation on UniProt →

Function. May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).

Subunit / interactions. Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1.

Subcellular location. Nucleus.

Tissue specificity. Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.

Activity regulation. Beta-lactamase activity is inhibited by sulbactam.

Induction. During mitosis. The mRNA encoding this protein contains an internal ribosome entry site (IRES) in its 5’-UTR. This 5’-UTR generally suppresses translation while specifically promoting expression during mitosis, when cap-dependent translation may be impaired.

Similarity. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.

RefSeq proteins (2): NP_001258745, NP_055696* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006642	Rad18_UBZ4	Domain
IPR011084	DRMBL	Domain
IPR036866	RibonucZ/Hydroxyglut_hydro	Homologous_superfamily

Pfam: PF07522

Catalyzed reactions (Rhea), 1 shown:

• a beta-lactam + H2O = a substituted beta-amino acid (RHEA:20401)

UniProt features (75 total): strand 19, helix 16, cross-link 14, sequence variant 7, region of interest 5, binding site 4, turn 4, mutagenesis site 2, chain 1, zinc finger region 1, modified residue 1, compositionally biased region 1

Structure

Experimental structures (PDB)

318 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
5Q22	X-RAY DIFFRACTION	1.18
5Q7C	X-RAY DIFFRACTION	1.2
5Q82	X-RAY DIFFRACTION	1.2
5Q74	X-RAY DIFFRACTION	1.21
5Q8D	X-RAY DIFFRACTION	1.23
5Q8X	X-RAY DIFFRACTION	1.23
5Q1O	X-RAY DIFFRACTION	1.25
5Q78	X-RAY DIFFRACTION	1.25
5Q7B	X-RAY DIFFRACTION	1.25
5Q7I	X-RAY DIFFRACTION	1.26
5Q7M	X-RAY DIFFRACTION	1.26
5Q7W	X-RAY DIFFRACTION	1.27
5Q2M	X-RAY DIFFRACTION	1.28
5Q76	X-RAY DIFFRACTION	1.28
5Q83	X-RAY DIFFRACTION	1.28
5Q9F	X-RAY DIFFRACTION	1.28
5Q3G	X-RAY DIFFRACTION	1.29
5Q6V	X-RAY DIFFRACTION	1.29
5Q2J	X-RAY DIFFRACTION	1.3
5Q54	X-RAY DIFFRACTION	1.3
5Q9M	X-RAY DIFFRACTION	1.3
5Q70	X-RAY DIFFRACTION	1.31
5Q72	X-RAY DIFFRACTION	1.31
5Q7S	X-RAY DIFFRACTION	1.31
5Q86	X-RAY DIFFRACTION	1.31
5Q99	X-RAY DIFFRACTION	1.31
5Q23	X-RAY DIFFRACTION	1.32
5Q7D	X-RAY DIFFRACTION	1.32
5Q7O	X-RAY DIFFRACTION	1.32
5Q8V	X-RAY DIFFRACTION	1.32

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6PJP8-F1	58.30	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 140; 144; 122; 125

Post-translational modifications (15): 590, 202, 236, 269, 353, 361, 429, 488, 508, 517, 533, 536, 668, 670, 674

Mutagenesis-validated functional residues (2):

Position	Phenotype
838	impaired nuclear focus formation, reduced interaction with pias and increased sensitivity to cisplatin.
994	impaired nuclear focus formation, reduced interaction with pias and increased sensitivity to cisplatin.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6783310	Fanconi Anemia Pathway

MSigDB gene sets: 167 (showing top): E2F_Q4_01, FISCHER_G1_S_CELL_CYCLE, GOMF_NUCLEASE_ACTIVITY, KAUFFMANN_DNA_REPAIR_GENES, GGGTGGRR_PAX4_03, CAGCTG_AP4_Q5, WTGAAAT_UNKNOWN, GOBP_DNA_DAMAGE_RESPONSE, GOBP_INTERSTRAND_CROSS_LINK_REPAIR, SCHLOSSER_SERUM_RESPONSE_DN, FISCHER_DREAM_TARGETS, REACTOME_FANCONI_ANEMIA_PATHWAY, REACTOME_DNA_REPAIR, GOMF_EXONUCLEASE_ACTIVITY, E2F_Q6_01

GO Biological Process (5): double-strand break repair via nonhomologous end joining (GO:0006303), interstrand cross-link repair (GO:0036297), cell division (GO:0051301), DNA repair (GO:0006281), DNA damage response (GO:0006974)

GO Molecular Function (7): damaged DNA binding (GO:0003684), zinc ion binding (GO:0008270), beta-lactamase activity (GO:0008800), 5’-3’ DNA exonuclease activity (GO:0035312), DNA binding (GO:0003677), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)

GO Cellular Component (3): fibrillar center (GO:0001650), nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
DNA Repair	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
double-strand break repair	1
DNA repair	1
cellular process	1
DNA metabolic process	1
DNA damage response	1
cellular response to stress	1
DNA binding	1
transition metal ion binding	1
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	1
5’-3’ exonuclease activity	1
DNA exonuclease activity, producing 5’-phosphomonoesters	1
nucleic acid binding	1
catalytic activity	1
cation binding	1
nucleolus	1
intracellular membrane-bounded organelle	1
nuclear lumen	1

Protein interactions and networks

STRING

1469 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DCLRE1A	CPSF3	Q9UKF6	940
DCLRE1A	CPSF2	Q9P2I0	900
DCLRE1A	ELAC2	Q9BQ52	822
DCLRE1A	MRE11	P49959	737
DCLRE1A	TFAP4	Q01664	718
DCLRE1A	FANCD2	Q9BXW9	701
DCLRE1A	SLX4	Q8IY92	699
DCLRE1A	FANCI	Q9NVI1	691
DCLRE1A	MUS81	Q96NY9	687
DCLRE1A	RAD51	Q06609	687
DCLRE1A	SLX1A	Q9BQ83	684
DCLRE1A	FANCM	Q8IYD8	674
DCLRE1A	RAD18	Q9NS91	666
DCLRE1A	REV3L	O60673	659
DCLRE1A	ERCC1	P07992	641

IntAct

8 interactions, top by confidence:

A	B	Type	Score
YWHAH	FAM83G	psi-mi:“MI:0914”(association)	0.710
PCNA	RFC4	psi-mi:“MI:0914”(association)	0.530
DCLRE1A	KTN1	psi-mi:“MI:0915”(physical association)	0.400
DCLRE1A	U2SURP	psi-mi:“MI:0915”(physical association)	0.400
DCLRE1A	KPNA1	psi-mi:“MI:0915”(physical association)	0.400
DCLRE1A	ADRB2	psi-mi:“MI:0915”(physical association)	0.370
BRCA1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (32): DCLRE1A (Affinity Capture-MS), DCLRE1A (Affinity Capture-Western), DCLRE1A (Proximity Label-MS), TP53BP1 (Affinity Capture-Western), DCLRE1A (Affinity Capture-MS), DCLRE1A (Affinity Capture-MS), DCLRE1A (Proximity Label-MS), KTN1 (Proximity Label-MS), DCLRE1A (Proximity Label-MS), DCLRE1A (Two-hybrid), DCLRE1A (Proximity Label-MS), KPNA1 (Affinity Capture-MS), DCLRE1A (Affinity Capture-MS), DCLRE1A (Proximity Label-MS), DCLRE1A (Proximity Label-MS)

ESM2 similar proteins: A0JM98, A1L1H3, B7ZS37, D2H3M0, D3ZF42, E1BPH3, E2QTD3, F6YVB9, O75113, O88866, P62287, P62288, Q01804, Q13129, Q1L981, Q2T9I9, Q5H9M0, Q5HZN1, Q5QJC4, Q5SW75, Q5T5J6, Q5VCS6, Q5XIS7, Q5ZIX8, Q5ZKI7, Q5ZLE9, Q61194, Q63679, Q6A037, Q6DJS0, Q6GQJ2, Q6IE81, Q6IE82, Q6IFT4, Q6IVY4, Q6NRK3, Q6PCM1, Q6PJP8, Q6PUR7, Q6YI93

Diamond homologs: B0V2S2, D2H8V8, F4HPZ9, Q38961, Q4KLY6, Q55470, Q5QJC3, Q5QJC4, Q5R6Z9, Q5XIX3, Q6PJP8, Q86KS1, Q8C7W7, Q8K4J0, Q96SD1, Q9H816, Q9JIC3, P30620, Q5QJC2, Q5RGE5, A1RTK4, A1RY72, A2BJX6, A3DP49, A3MS62, A4WH24, A4YD25, A8AB20, A8MDU6, B1L3V2, B1YA52, C0QSL7, C3MJ14, C3MYD2, C3MZR1, C3N834, C3NF77, C4KIZ2, D2CJS7, O67398

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

159 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	127
Likely benign	16
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1669 predictions. Top by Δscore:

Variant	Effect	Δscore
10:113835310:TTC:T	acceptor_gain	1.0000
10:113835311:TC:T	acceptor_gain	1.0000
10:113835311:TCC:T	acceptor_loss	1.0000
10:113835312:CC:C	acceptor_gain	1.0000
10:113835313:C:CA	acceptor_loss	1.0000
10:113835313:C:CC	acceptor_gain	1.0000
10:113837078:T:A	donor_gain	1.0000
10:113841401:CTTA:C	donor_loss	1.0000
10:113841402:TTACC:T	donor_loss	1.0000
10:113841403:TACC:T	donor_loss	1.0000
10:113841404:ACC:A	donor_loss	1.0000
10:113841405:C:CA	donor_loss	1.0000
10:113841557:ATGG:A	acceptor_gain	1.0000
10:113841558:TGG:T	acceptor_gain	1.0000
10:113841561:C:CC	acceptor_gain	1.0000
10:113842335:CAA:C	donor_gain	1.0000
10:113842338:CTCA:C	donor_loss	1.0000
10:113842339:TCACC:T	donor_loss	1.0000
10:113842340:C:CA	donor_loss	1.0000
10:113842341:ACCT:A	donor_loss	1.0000
10:113842510:CTTA:C	acceptor_gain	1.0000
10:113844204:C:CT	acceptor_gain	1.0000
10:113844206:T:TC	acceptor_gain	1.0000
10:113845676:AATAC:A	donor_loss	1.0000
10:113845677:ATACT:A	donor_loss	1.0000
10:113845678:TACTT:T	donor_loss	1.0000
10:113845679:AC:A	donor_loss	1.0000
10:113845680:CTTAC:C	donor_loss	1.0000
10:113845681:TT:T	donor_loss	1.0000
10:113845682:TAC:T	donor_loss	1.0000

AlphaMissense

6872 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:113835175:A:G	W1034R	0.997
10:113835175:A:T	W1034R	0.997
10:113837148:A:G	F959S	0.997
10:113844110:T:A	D838V	0.997
10:113835290:G:C	S995R	0.996
10:113835290:G:T	S995R	0.996
10:113835292:T:G	S995R	0.996
10:113842384:A:T	V875D	0.996
10:113847320:A:T	V714D	0.996
10:113835264:A:T	V1004D	0.995
10:113837134:A:G	W964R	0.995
10:113837134:A:T	W964R	0.995
10:113842387:A:T	V874D	0.995
10:113844110:T:G	D838A	0.995
10:113837151:G:T	A958E	0.994
10:113842360:T:A	K883I	0.994
10:113842423:G:T	A862D	0.993
10:113844111:C:G	D838H	0.993
10:113847254:T:A	D736V	0.993
10:113835173:C:A	W1034C	0.992
10:113835173:C:G	W1034C	0.992
10:113835255:A:G	L1007P	0.992
10:113835299:A:C	S992R	0.992
10:113835299:A:T	S992R	0.992
10:113835301:T:G	S992R	0.992
10:113842382:A:G	C876R	0.992
10:113844109:A:C	D838E	0.992
10:113844109:A:T	D838E	0.992
10:113844119:A:G	L835P	0.992
10:113844243:A:G	C794R	0.992

dbSNP variants (sampled 300 via entrez): RS1000090872 (10:113842887 A>G), RS1000276103 (10:113855076 G>A,T), RS1000546354 (10:113842414 G>A), RS1000567825 (10:113854625 G>A,C,T), RS1000579908 (10:113847616 A>G), RS1000686222 (10:113835806 A>G), RS1000869165 (10:113834403 G>A,C), RS1000954082 (10:113835577 G>C), RS1001147601 (10:113840653 T>C), RS1001209201 (10:113854252 A>C), RS1001308602 (10:113841868 T>A,C), RS1001352996 (10:113855467 T>G), RS1001365331 (10:113838583 C>A), RS1001866166 (10:113843022 G>GTA), RS1001880038 (10:113854170 C>T)

Disease associations

OMIM: gene MIM:609682 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105903 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	2
Hydrogen Peroxide	affects expression, increases expression	2
Cyclosporine	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
FR900359	decreases phosphorylation	1
TAK-243	affects sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
CPG-oligonucleotide	decreases expression	1
K 7174	decreases expression	1
ICG 001	increases expression	1
Irinotecan	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Caffeine	affects phosphorylation	1
Cisplatin	increases expression	1
Coumestrol	affects cotreatment, increases expression	1
Naled	affects expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases methylation	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4027951	Binding	Inhibition of human DCLRE1A	In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors. — J Med Chem

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1VC	HAP1 DCLRE1A (-) 1	Cancer cell line	Male
CVCL_E1VD	HAP1 DCLRE1A (-) 2	Cancer cell line	Male
CVCL_E1VE	HAP1 DCLRE1A (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.