DCP2

Summary

DCP2 (decapping mRNA 2, HGNC:24452) is a protein-coding gene on chromosome 5q22.2, encoding m7GpppN-mRNA hydrolase (Q8IU60). Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. It is a selective cancer dependency (DepMap: 10.9% of cell lines).

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5’ end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Source: NCBI Gene 167227 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 79 total
• Cancer dependency (DepMap): dependent in 10.9% of screened cell lines
• MANE Select transcript: NM_152624

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24452
Approved symbol	DCP2
Name	decapping mRNA 2
Location	5q22.2
Locus type	gene with protein product
Status	Approved
Aliases	NUDT20
Ensembl gene	ENSG00000172795
Ensembl biotype	protein_coding
OMIM	609844
Entrez	167227

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 3 protein_coding, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000389063, ENST00000502635, ENST00000504961, ENST00000508359, ENST00000510046, ENST00000512751, ENST00000513585, ENST00000515408, ENST00000674880

RefSeq mRNA: 2 — MANE Select: NM_152624 NM_001242377, NM_152624

CCDS: CCDS34210, CCDS56377

Canonical transcript exons

ENST00000389063 — 11 exons

Exon	Start	End
ENSE00001082534	113007938	113008042
ENSE00001261172	112976798	112976986
ENSE00001504831	113013321	113022195
ENSE00001504832	113010756	113010807
ENSE00001504834	112985835	112985986
ENSE00003469422	112992672	112992770
ENSE00003567570	113001357	113001469
ENSE00003599316	112992121	112992248
ENSE00003641482	113003942	113004077
ENSE00003663289	113001084	113001236
ENSE00003670909	113001567	113001674

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 98.03.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.7292 / max 446.5258, expressed in 1816 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58017	33.8599	1809
58016	3.0283	1331
58015	0.5297	275
58018	0.3113	159

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	98.03	gold quality
secondary oocyte	CL:0000655	97.52	gold quality
trabecular bone tissue	UBERON:0002483	95.11	gold quality
adrenal tissue	UBERON:0018303	95.10	gold quality
sperm	CL:0000019	93.97	gold quality
parietal pleura	UBERON:0002400	93.93	gold quality
placenta	UBERON:0001987	93.85	gold quality
pleura	UBERON:0000977	93.80	gold quality
monocyte	CL:0000576	93.42	gold quality
mononuclear cell	CL:0000842	93.40	gold quality
bone marrow	UBERON:0002371	93.35	gold quality
visceral pleura	UBERON:0002401	93.35	gold quality
leukocyte	CL:0000738	93.16	gold quality
epithelium of nasopharynx	UBERON:0001951	93.06	gold quality
choroid plexus epithelium	UBERON:0003911	92.99	gold quality
endothelial cell	CL:0000115	92.89	gold quality
cartilage tissue	UBERON:0002418	92.86	gold quality
calcaneal tendon	UBERON:0003701	92.81	gold quality
germinal epithelium of ovary	UBERON:0001304	92.68	gold quality
blood	UBERON:0000178	92.38	gold quality
male germ cell	CL:0000015	91.74	gold quality
tibia	UBERON:0000979	91.25	gold quality
amniotic fluid	UBERON:0000173	91.03	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.01	gold quality
palpebral conjunctiva	UBERON:0001812	90.86	gold quality
mucosa of paranasal sinus	UBERON:0005030	90.66	gold quality
skin of hip	UBERON:0001554	90.47	gold quality
superficial temporal artery	UBERON:0001614	90.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.24	gold quality
hair follicle	UBERON:0002073	89.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.89

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

272 targeting DCP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-499A-5P	99.98	70.79	1323

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 10.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 15)

• an mRNA decapping enzyme demonstrated to contain intrinsic decapping activity (PMID:12218187)
• These data suggest that a human decapping complex containing decapping enzymes hDcp1a and hDcp2 may be recruited to mRNAs containing premature termination codons by the hUpf proteins. (PMID:12417715)
• Human Dcp2 is a catalytically active mRNA decapping enzyme that localizes to the cytoplasm (PMID:12486012)
• LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci (PMID:12515382)
• hDcp2 can specifically bind to and can regulate the stability of a subset of mRNAs (PMID:18039849)
• These data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation. (PMID:18361920)
• Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis. (PMID:21070968)
• PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2. (PMID:23085078)
• Data show that Y14 interacts directly with the decapping factor Dcp2 and the 5’ cap structure of mRNAs via different but overlapping domains. (PMID:23115303)
• The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5’-to-3’ mRNA degradation by XRN1 in human cells. (PMID:24510189)
• Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation. (PMID:25870104)
• Human MARF1 is an endoribonuclease that interacts with the DCP1:DCP2 decapping complex and degrades target mRNAs. (PMID:30364987)
• Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA. (PMID:36130271)
• Decapping enzyme 2 is a novel immune-related biomarker that predicts poor prognosis in glioma. (PMID:37191010)
• MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties. (PMID:37437058)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	dcp2	ENSDARG00000104242
mus_musculus	Dcp2	ENSMUSG00000024472
rattus_norvegicus	Dcp2	ENSRNOG00000045895
drosophila_melanogaster	DCP2	FBGN0036534
caenorhabditis_elegans		WBGENE00003582

Protein

Protein identifiers

m7GpppN-mRNA hydrolase — Q8IU60 (reviewed: Q8IU60)

Alternative names: Nucleoside diphosphate-linked moiety X motif 20, mRNA-decapping enzyme 2

All UniProt accessions (4): A0A6Q8PGI4, A0A6Q8PGL6, B7Z3U5, Q8IU60

UniProt curated annotations — full annotation on UniProt →

Function. Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2’-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.

Subunit / interactions. Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS. Interacts with DPC1B. Interacts (via N-terminus and C-terminus) with TRIM21 (via N-terminus and C-terminus). Associates with polysomes. Interacts with LIMD1, WTIP and AJUBA. Interacts with DDX17 in an RNA-dependent manner. Interacts with ZC3HAV1. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with ZFP36L1 (via N-terminus). Interacts with NBDY.

Subcellular location. Cytoplasm. P-body. Nucleus.

Tissue specificity. Expressed in brain and testis. Not detected in heart (at protein level).

Post-translational modifications. Phosphorylated at ser-249 in a MTOR-dependent manner.

Cofactor. Mn(2+) ion is required for highest activity. Can also utilize magnesium ions.

Similarity. Belongs to the Nudix hydrolase family. DCP2 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IU60-1	1	yes
Q8IU60-2	2

RefSeq proteins (2): NP_001229306, NP_689837* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000086	NUDIX_hydrolase_dom	Domain
IPR007722	DCP2_BoxA	Domain
IPR015797	NUDIX_hydrolase-like_dom_sf	Homologous_superfamily
IPR020084	NUDIX_hydrolase_CS	Conserved_site
IPR036189	DCP2_BoxA_sf	Homologous_superfamily
IPR044099	Dcp2_NUDIX	Domain

Pfam: PF00293, PF05026

Enzyme classification (BRENDA):

• EC 3.6.1.62 — 5’-(N7-methylguanosine 5’-triphospho)-[mRNA] hydrolase (BRENDA: 21 organisms, 123 substrates, 18 inhibitors, 4 Km, 3 kcat entries)

Substrate kinetics (BRENDA)

4 substrates with measured Km, best-characterized 4. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
ADP	0.185	1
ITP	0.0082	1
M7G5’PPP5’-MRNA	0.0034	1
XDP	0.0062	1

Catalyzed reactions (Rhea), 1 shown:

• a 5’-end (N(7)-methyl 5’-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5’-end phospho-ribonucleoside in mRNA + 2 H(+) (RHEA:67484)

UniProt features (36 total): strand 8, modified residue 5, helix 5, mutagenesis site 4, turn 3, region of interest 2, binding site 2, chain 1, domain 1, splice variant 1, sequence variant 1, sequence conflict 1, short sequence motif 1, compositionally biased region 1

Structure

Experimental structures (PDB)

33 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
5QOQ	X-RAY DIFFRACTION	1.49
5QOO	X-RAY DIFFRACTION	1.56
5QPA	X-RAY DIFFRACTION	1.61
5MP0	X-RAY DIFFRACTION	1.63
5QP8	X-RAY DIFFRACTION	1.64
5QOV	X-RAY DIFFRACTION	1.65
5QP6	X-RAY DIFFRACTION	1.65
5QPC	X-RAY DIFFRACTION	1.66
5QOT	X-RAY DIFFRACTION	1.68
5QPB	X-RAY DIFFRACTION	1.68
5QOY	X-RAY DIFFRACTION	1.69
5QOS	X-RAY DIFFRACTION	1.7
5QOZ	X-RAY DIFFRACTION	1.7
5QP4	X-RAY DIFFRACTION	1.71
5QP9	X-RAY DIFFRACTION	1.72
5QP3	X-RAY DIFFRACTION	1.75
5QP1	X-RAY DIFFRACTION	1.79
5QON	X-RAY DIFFRACTION	1.8
5QOW	X-RAY DIFFRACTION	1.82
5QP2	X-RAY DIFFRACTION	1.83
5QOL	X-RAY DIFFRACTION	1.85
5QOP	X-RAY DIFFRACTION	1.86
5QOM	X-RAY DIFFRACTION	1.87
5QP7	X-RAY DIFFRACTION	1.88
5QP5	X-RAY DIFFRACTION	1.9
5QOH	X-RAY DIFFRACTION	1.93
5QOR	X-RAY DIFFRACTION	1.95
5QOX	X-RAY DIFFRACTION	1.95
5QOI	X-RAY DIFFRACTION	1.99
5QP0	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IU60-F1	67.25	0.35

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 144; 148

Post-translational modifications (5): 249, 276, 284, 246, 247

Mutagenesis-validated functional residues (4):

Position	Phenotype
147	loss of decapping activity; when associated with q-148.
148	strongly reduced decapping activity.
249	leads to the accumulation of autophagosomes under normal growth conditions.
249	leads to reduced autophagosome formation under autophagy-inducing conditions.

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-380994	ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-430039	mRNA decay by 5’ to 3’ exoribonuclease
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA

MSigDB gene sets: 266 (showing top): GOBP_RNA_TEMPLATED_DNA_BIOSYNTHETIC_PROCESS, GOBP_CHROMOSOME_ORGANIZATION, REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, GOMF_RNA_NUCLEASE_ACTIVITY, GOBP_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GOMF_NUCLEASE_ACTIVITY, TTTGTAG_MIR520D, REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING, GOBP_TELOMERE_ORGANIZATION, MITSIADES_RESPONSE_TO_APLIDIN_DN, CTATGCA_MIR153, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION

GO Biological Process (9): nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184), nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288), deadenylation-dependent decapping of nuclear-transcribed mRNA (GO:0000290), mRNA catabolic process (GO:0006402), negative regulation of telomere maintenance via telomerase (GO:0032211), regulation of mRNA stability (GO:0043488), histone mRNA catabolic process (GO:0071044), regulation of telomerase RNA localization to Cajal body (GO:1904872), mRNA metabolic process (GO:0016071)

GO Molecular Function (9): 5’-3’ RNA exonuclease activity (GO:0004534), RNA exonuclease activity, producing 5’-phosphomonoesters (GO:0016896), manganese ion binding (GO:0030145), telomerase RNA binding (GO:0070034), 5’-(N(7)-methylguanosine 5’-triphospho)-[mRNA] hydrolase activity (GO:0140933), RNA binding (GO:0003723), protein binding (GO:0005515), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)

GO Cellular Component (8): P-body (GO:0000932), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), RISC complex (GO:0016442), cell junction (GO:0030054), cytoplasmic ribonucleoprotein granule (GO:0036464), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements	3
PERK regulates gene expression	1
Deadenylation-dependent mRNA decay	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear-transcribed mRNA catabolic process	4
cellular anatomical structure	4
cytoplasm	2
mRNA destabilization	1
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	1
mRNA methylguanosine-cap decapping	1
RNA catabolic process	1
negative regulation of gene expression	1
mRNA metabolic process	1
telomere maintenance via telomerase	1
regulation of telomere maintenance via telomerase	1
negative regulation of telomere maintenance via telomere lengthening	1
negative regulation of DNA biosynthetic process	1
regulation of RNA stability	1
regulation of mRNA catabolic process	1
histone mRNA metabolic process	1
regulation of localization	1
telomerase RNA localization to Cajal body	1
RNA metabolic process	1
5’-3’ exonuclease activity	1
RNA exonuclease activity, producing 5’-phosphomonoesters	1
RNA exonuclease activity	1
transition metal ion binding	1
RNA binding	1
pyrophosphatase activity	1
nucleic acid binding	1
binding	1
catalytic activity	1
cation binding	1
cytoplasmic ribonucleoprotein granule	1
nuclear lumen	1
intracellular anatomical structure	1
RNAi effector complex	1
ribonucleoprotein granule	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1792 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DCP2	XRN1	Q8IZH2	999
DCP2	EDC3	Q96F86	999
DCP2	DCP1A	Q9NPI6	999
DCP2	EDC4	Q6P2E9	998
DCP2	DDX6	P26196	998
DCP2	LSM1	O15116	967
DCP2	UPF1	Q92900	933
DCP2	XRN2	Q9H0D6	899
DCP2	DCPS	Q96C86	879
DCP2	DXO	O77932	876
DCP2	VCX3A	Q9NNX9	855
DCP2	LSM14A	Q8ND56	845
DCP2	DCP1B	Q8IZD4	844
DCP2	UPF2	Q9HAU5	816
DCP2	EIF4E	P06730	809

IntAct

88 interactions, top by confidence:

A	B	Type	Score
DCP1A	DCP2	psi-mi:“MI:0914”(association)	0.950
DCP2	DCP1A	psi-mi:“MI:0915”(physical association)	0.950
DCP1A	DCP2	psi-mi:“MI:0403”(colocalization)	0.950
DCP1A	DCP2	psi-mi:“MI:0915”(physical association)	0.950
DCP2	DCP1A	psi-mi:“MI:0914”(association)	0.950
DCP1A	DDX6	psi-mi:“MI:0914”(association)	0.930
DCP2	EDC4	psi-mi:“MI:0915”(physical association)	0.890
EDC4	DCP2	psi-mi:“MI:0914”(association)	0.890
EDC4	DCP2	psi-mi:“MI:0915”(physical association)	0.890
XRN1	EDC4	psi-mi:“MI:0914”(association)	0.750
DCP1B	DCP2	psi-mi:“MI:0914”(association)	0.740
UPF1	DCP2	psi-mi:“MI:0915”(physical association)	0.640
UPF1	DCP2	psi-mi:“MI:0914”(association)	0.640
DCP2	UPF1	psi-mi:“MI:0915”(physical association)	0.640
LRRC32	SMPD2	psi-mi:“MI:0914”(association)	0.640
CRK	ARHGAP42	psi-mi:“MI:0914”(association)	0.530

BioGRID (170): DCP2 (Affinity Capture-MS), DCP2 (Affinity Capture-MS), DCP2 (Affinity Capture-MS), EDC3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), DCP1B (Affinity Capture-MS), DCP1A (Affinity Capture-MS), SQSTM1 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), TUBB8 (Affinity Capture-MS), EEF1A2 (Affinity Capture-MS), GAPDHS (Affinity Capture-MS), GBAS (Affinity Capture-MS), DCP2 (Affinity Capture-MS), DCP2 (Affinity Capture-MS)

ESM2 similar proteins: A9JRL3, E1C3P4, E9Q4Z2, E9Q5G3, F1M5F3, F1N2W9, F1ND48, F1QDI9, F6RIX4, I0IUP4, O00763, O88974, O94851, P51004, P55265, P55266, Q08J23, Q149N8, Q15047, Q2KHI9, Q4KWZ7, Q5R4N7, Q5R6Z9, Q5RGE5, Q5XIX3, Q5ZKK7, Q641K1, Q69ZT9, Q6NRM6, Q76CY8, Q7TPQ3, Q7TQE7, Q7ZU92, Q8BND4, Q8H2D5, Q8IU60, Q8K2I9, Q8K4J0, Q8K4S7, Q8NFZ0

Diamond homologs: A6ZRW5, O13828, O62255, P53550, Q5REQ8, Q75BK1, Q8GW31, Q8IU60, Q9CYC6, P0C996, P0C997, P32092, Q91FB1, P13420, P46351, Q196U9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 83 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA decay by 5’ to 3’ exoribonuclease	8	98.2×	1e-12

GO biological processes:

GO term	Partners	Fold	FDR
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5	32.1×	9e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1942 predictions. Top by Δscore:

Variant	Effect	Δscore
5:112976984:CAGGT:C	donor_loss	1.0000
5:112976985:AGGTA:A	donor_loss	1.0000
5:112976986:GG:G	donor_loss	1.0000
5:112976987:G:T	donor_loss	1.0000
5:112976988:T:G	donor_loss	1.0000
5:112985963:GGA:G	donor_gain	1.0000
5:112985965:A:G	donor_gain	1.0000
5:112992249:G:GG	donor_gain	1.0000
5:112992766:GAGAG:G	donor_gain	1.0000
5:112992767:AGAGG:A	donor_loss	1.0000
5:112992768:GAG:G	donor_gain	1.0000
5:112992768:GAGGT:G	donor_loss	1.0000
5:112992769:AGGT:A	donor_loss	1.0000
5:112992770:GGT:G	donor_loss	1.0000
5:112992771:G:GG	donor_gain	1.0000
5:112992772:TAAG:T	donor_loss	1.0000
5:113001079:TCCA:T	acceptor_loss	1.0000
5:113001081:CA:C	acceptor_loss	1.0000
5:113001082:A:AG	acceptor_gain	1.0000
5:113001083:G:GG	acceptor_gain	1.0000
5:113001187:G:GT	donor_gain	1.0000
5:113001235:GG:G	donor_gain	1.0000
5:113001236:GG:G	donor_gain	1.0000
5:113001237:G:GG	donor_gain	1.0000
5:113001562:TGCAG:T	acceptor_loss	1.0000
5:113001563:GCA:G	acceptor_loss	1.0000
5:113001564:CA:C	acceptor_loss	1.0000
5:113001565:A:AG	acceptor_gain	1.0000
5:113001565:A:AT	acceptor_loss	1.0000
5:113001566:G:GA	acceptor_gain	1.0000

AlphaMissense

2818 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:112985839:T:C	F20L	1.000
5:112985840:T:C	F20S	1.000
5:112985841:T:A	F20L	1.000
5:112985841:T:G	F20L	1.000
5:112985890:T:C	F37L	1.000
5:112985892:T:A	F37L	1.000
5:112985892:T:G	F37L	1.000
5:112985901:A:C	E40D	1.000
5:112985901:A:T	E40D	1.000
5:112985903:T:C	L41P	1.000
5:112985911:T:A	W44R	1.000
5:112985911:T:C	W44R	1.000
5:112985913:G:C	W44C	1.000
5:112985913:G:T	W44C	1.000
5:112985914:T:C	F45L	1.000
5:112985916:T:A	F45L	1.000
5:112985916:T:G	F45L	1.000
5:112985924:A:T	D48V	1.000
5:112985975:T:C	F65S	1.000
5:112985978:C:A	A66D	1.000
5:112992183:T:A	W90R	1.000
5:112992183:T:C	W90R	1.000
5:112992184:G:C	W90S	1.000
5:112992185:G:C	W90C	1.000
5:112992185:G:T	W90C	1.000
5:112992192:T:C	Y93H	1.000
5:112992195:A:G	K94E	1.000
5:112992197:A:C	K94N	1.000
5:112992197:A:T	K94N	1.000
5:112992216:G:C	G101R	1.000

dbSNP variants (sampled 300 via entrez): RS1000050143 (5:113012005 T>C), RS1000053890 (5:113008988 T>C), RS1000115411 (5:113017056 G>C,T), RS1000373899 (5:113016662 T>C), RS1000462900 (5:113011978 A>G,T), RS1000550175 (5:112977917 T>A,C), RS1000615171 (5:112982712 C>T), RS1000645168 (5:112977777 A>G), RS1000672670 (5:113007039 G>A), RS1000688067 (5:112977007 C>G,T), RS1000739850 (5:112976798 C>G,T), RS1000763527 (5:113003318 A>G), RS1000870217 (5:112999167 T>C), RS1000888572 (5:112990121 G>C), RS1000898524 (5:113002541 A>T)

Disease associations

OMIM: gene MIM:609844 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007708_7	Worry/vulnerability (special factor of neuroticism)	6.000000e-10
GCST011688_1	Waist circumference	3.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009589	worry measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, increases expression	2
Valproic Acid	decreases expression, decreases methylation, increases expression	2
GSK-J4	increases expression	1
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
trichostatin A	increases expression	1
arsenite	affects binding, decreases reaction	1
methylparaben	decreases expression	1
coumarin	increases phosphorylation	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	increases reaction, affects binding	1
jinfukang	decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases response to substance	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Gold	decreases expression	1
Methotrexate	affects response to substance	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
RNA Cap Analogs	affects response to substance	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B7WZ	Abcam Raji DCP2 KO	Cancer cell line	Male
CVCL_B9XK	Abcam THP-1 DCP2 KO	Cancer cell line	Male
CVCL_C6ZF	Abcam PC-3 DCP2 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.