DCST1-AS1

Summary

DCST1-AS1 (DCST1 antisense RNA 1, HGNC:41147) is a long non-coding RNA gene on chromosome 1q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41147
Approved symbol	DCST1-AS1
Name	DCST1 antisense RNA 1
Location	1q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-307C12.11
Ensembl gene	ENSG00000232093
Ensembl biotype	lncRNA
Entrez	100505666
RNAcentral	URS000075A153 — lncRNA, 1617 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000452962

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000452962 — 4 exons

Exon	Start	End
ENSE00001657244	155045191	155045853
ENSE00004216805	155049269	155049361
ENSE00004216806	155050607	155051172
ENSE00004216807	155045960	155046155

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 85.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.8143 / max 37.6055, expressed in 1119 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14895	2.4717	1051
14896	0.3425	182

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.94	gold quality
bone marrow cell	CL:0002092	80.48	gold quality
skin of leg	UBERON:0001511	80.37	gold quality
skin of abdomen	UBERON:0001416	79.60	gold quality
zone of skin	UBERON:0000014	77.33	gold quality
left ventricle myocardium	UBERON:0006566	74.16	gold quality
mucosa of transverse colon	UBERON:0004991	73.72	gold quality
cardiac muscle of right atrium	UBERON:0003379	73.65	gold quality
lower esophagus mucosa	UBERON:0035834	73.14	gold quality
esophagus mucosa	UBERON:0002469	71.99	gold quality
kidney epithelium	UBERON:0004819	71.94	gold quality
nasal cavity epithelium	UBERON:0005384	71.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.43	gold quality
minor salivary gland	UBERON:0001830	70.46	gold quality
parotid gland	UBERON:0001831	69.93	gold quality
myocardium	UBERON:0002349	69.44	gold quality
saliva-secreting gland	UBERON:0001044	69.19	gold quality
right lobe of liver	UBERON:0001114	69.03	gold quality
pancreatic ductal cell	CL:0002079	68.54	silver quality
mouth mucosa	UBERON:0003729	68.49	gold quality
tibialis anterior	UBERON:0001385	68.29	silver quality
rectum	UBERON:0001052	67.44	gold quality
ventricular zone	UBERON:0003053	67.34	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	66.76	gold quality
transverse colon	UBERON:0001157	66.40	gold quality
ileal mucosa	UBERON:0000331	65.70	gold quality
epithelium of mammary gland	UBERON:0003244	65.58	gold quality
mammary duct	UBERON:0001765	65.48	gold quality
cortical plate	UBERON:0005343	65.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• DCST1-AS1 up-regulates the expression of FAIM2 by up-regulating the expression of miR-1254, ultimately promoting the proliferation of hepatocellular carcinoma cells. (PMID:30617187)
• LncRNA DCST1-AS1 accelerates the proliferation, metastasis and autophagy of hepatocellular carcinoma cell by AKT/mTOR signaling pathways. (PMID:31364110)
• Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression. (PMID:33025624)
• lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-kappaB Signaling. (PMID:34414241)
• LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation. (PMID:38063091)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.