DCTN3

Summary

DCTN3 (dynactin subunit 3, HGNC:2713) is a protein-coding gene on chromosome 9p13.3, encoding Dynactin subunit 3 (O75935). Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. It is a selective cancer dependency (DepMap: 87.3% of cell lines).

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 11258 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 39 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 87.3% of screened cell lines
• MANE Select transcript: NM_007234

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2713
Approved symbol	DCTN3
Name	dynactin subunit 3
Location	9p13.3
Locus type	gene with protein product
Status	Approved
Aliases	DCTN-22
Ensembl gene	ENSG00000137100
Ensembl biotype	protein_coding
OMIM	607387
Entrez	11258

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 12 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000259632, ENST00000341694, ENST00000378911, ENST00000378913, ENST00000378916, ENST00000421919, ENST00000472074, ENST00000472418, ENST00000477738, ENST00000479399, ENST00000481438, ENST00000888986, ENST00000888987, ENST00000940739, ENST00000962454, ENST00000962455

RefSeq mRNA: 5 — MANE Select: NM_007234 NM_001281425, NM_001281426, NM_001281427, NM_007234, NM_024348

CCDS: CCDS65028, CCDS65029, CCDS6560, CCDS6561

Canonical transcript exons

ENST00000259632 — 7 exons

Exon	Start	End
ENSE00000832927	34616030	34616113
ENSE00000832928	34617885	34617971
ENSE00000832929	34618676	34618760
ENSE00001190026	34620369	34620495
ENSE00003521370	34614710	34614768
ENSE00003566797	34614042	34614101
ENSE00003850373	34613546	34613871

Expression profiles

Bgee: expression breadth ubiquitous, 298 present calls, max score 98.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 64.2891 / max 245.6869, expressed in 1823 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100527	64.2891	1823

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	98.41	gold quality
ganglionic eminence	UBERON:0004023	98.16	gold quality
prefrontal cortex	UBERON:0000451	98.06	gold quality
ventricular zone	UBERON:0003053	98.00	gold quality
right frontal lobe	UBERON:0002810	97.94	gold quality
adenohypophysis	UBERON:0002196	97.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.78	gold quality
pituitary gland	UBERON:0000007	97.71	gold quality
cerebellar hemisphere	UBERON:0002245	97.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.59	gold quality
cerebellar cortex	UBERON:0002129	97.58	gold quality
nucleus accumbens	UBERON:0001882	97.52	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.44	gold quality
skin of leg	UBERON:0001511	97.43	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	97.42	gold quality
skin of abdomen	UBERON:0001416	97.36	gold quality
cingulate cortex	UBERON:0003027	97.34	gold quality
anterior cingulate cortex	UBERON:0009835	97.27	gold quality
caudate nucleus	UBERON:0001873	97.17	gold quality
amygdala	UBERON:0001876	97.14	gold quality
parotid gland	UBERON:0001831	97.10	gold quality
cerebellum	UBERON:0002037	97.10	gold quality
frontal cortex	UBERON:0001870	97.05	gold quality
frontal lobe	UBERON:0016525	97.05	gold quality
neocortex	UBERON:0001950	97.03	gold quality
heart left ventricle	UBERON:0002084	97.02	gold quality
monocyte	CL:0000576	96.99	gold quality
pons	UBERON:0000988	96.98	gold quality
right atrium auricular region	UBERON:0006631	96.96	gold quality
zone of skin	UBERON:0000014	96.95	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.23
E-MTAB-10553	yes	7.06
E-MTAB-6379	no	427.07

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

13 targeting DCTN3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-4786-3P	99.36	68.35	1390
HSA-MIR-4312	99.34	67.30	511
HSA-MIR-7109-5P	99.18	66.13	1057
HSA-MIR-5701	98.97	69.54	1502
HSA-MIR-6780A-3P	98.42	67.49	1518
HSA-MIR-7843-3P	98.31	67.94	803
HSA-MIR-4684-3P	98.24	69.91	1075
HSA-MIR-6728-5P	97.79	66.33	891
HSA-MIR-668-3P	96.18	65.80	673

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 87.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C was much lower than the expression of dynactin subunits DCTN1 and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases (PMID:26954557)
• Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma. (PMID:33896271)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dctn3	ENSDARG00000041363
mus_musculus	Dctn3	ENSMUSG00000028447
rattus_norvegicus	Dctn3l1	ENSRNOG00000081039

Protein

Protein identifiers

Dynactin subunit 3 — O75935 (reviewed: O75935)

Alternative names: Dynactin complex subunit 22 kDa subunit

All UniProt accessions (5): A0A0A0MRV8, O75935, X6RA56, X6RCK5, X6RLR1

UniProt curated annotations — full annotation on UniProt →

Function. Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Together with dynein may be involved in spindle assembly and cytokinesis.

Subunit / interactions. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Chromosome. Centromere. Kinetochore. Spindle. Cleavage furrow. Midbody.

Tissue specificity. Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.

Similarity. Belongs to the dynactin subunit 3 family.

Isoforms (3)

UniProt ID	Names	Canonical?
O75935-1	1	yes
O75935-2	2
O75935-3	3

RefSeq proteins (5): NP_001268354, NP_001268355, NP_001268356, NP_009165, NP_077324 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009991	DCTN3	Family

Pfam: PF07426

UniProt features (6 total): splice variant 2, initiator methionine 1, chain 1, coiled-coil region 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9B7J	ELECTRON MICROSCOPY	3.49

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75935-F1	88.58	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

11 pathways

ID	Pathway
R-HSA-2132295	MHC class II antigen presentation
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
R-HSA-380259	Loss of Nlp from mitotic centrosomes
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518	AURKA Activation by TPX2

MSigDB gene sets: 184 (showing top): RNGTGGGC_UNKNOWN, FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, MODULE_255, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, MODULE_317, MODULE_128, REACTOME_MEMBRANE_TRAFFICKING, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_CYTOKINESIS, TGCTGAY_UNKNOWN, OCT1_03, chr9p13, GOCC_CENTROSOME

GO Biological Process (4): mitotic cell cycle (GO:0000278), microtubule-based process (GO:0007017), cytoskeleton-dependent cytokinesis (GO:0061640), cell division (GO:0051301)

GO Molecular Function (2): structural molecule activity (GO:0005198), protein binding (GO:0005515)

GO Cellular Component (18): kinetochore (GO:0000776), nucleolus (GO:0005730), centrosome (GO:0005813), spindle (GO:0005819), cytosol (GO:0005829), dynactin complex (GO:0005869), midbody (GO:0030496), cleavage furrow (GO:0032154), perinuclear theca (GO:0033011), perinuclear region of cytoplasm (GO:0048471), sperm midpiece (GO:0097225), sperm principal piece (GO:0097228), sperm glycocalyx (GO:0120238), chromosome, centromeric region (GO:0000775), chromosome (GO:0005694), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), microtubule associated complex (GO:0005875)

Reactome top-level categories

Rollup of top-9 pathways:

Category	Pathways
G2/M Transition	2
Centrosome maturation	2
Adaptive Immune System	1
Cellular responses to stress	1
Loss of proteins required for interphase microtubule organization from the centrosome	1
Mitotic Prometaphase	1
Assembly of the 9+0 primary cilium	1
ER to Golgi Anterograde Transport	1
Golgi-to-ER retrograde transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	6
intracellular membraneless organelle	5
cellular process	2
microtubule cytoskeleton	2
cytoplasm	2
sperm flagellum	2
cell cycle	1
mitotic nuclear division	1
cytokinesis	1
molecular_function	1
binding	1
condensed chromosome, centromeric region	1
supramolecular complex	1
nuclear lumen	1
centriole	1
microtubule organizing center	1
microtubule associated complex	1
actin cytoskeleton	1
cell division site	1
plasma membrane region	1
cytoskeleton	1
perinuclear region of cytoplasm	1
glycocalyx	1
chromosomal region	1
intracellular anatomical structure	1
protein-containing complex	1

Protein interactions and networks

STRING

1230 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DCTN3	DCTN1	Q14203	938
DCTN3	DCTN6	O00399	859
DCTN3	DCTN2	Q13561	832
DCTN3	DCTN5	Q9BTE1	773
DCTN3	ACTR1A	P42024	695
DCTN3	ACTR10	Q9NZ32	689
DCTN3	DCTN4	Q9UJW0	669
DCTN3	RPP25L	Q8N5L8	609
DCTN3	FAM219A	Q8IW50	584
DCTN3	ACTR1B	P42025	502
DCTN3	ENHO	Q6UWT2	470
DCTN3	ACTB	P02570	444
DCTN3	CAPZA2	P47755	421
DCTN3	RBM18	Q96H35	418
DCTN3	CAPZA1	P52907	417

IntAct

98 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
GPS2	HDAC3	psi-mi:“MI:0914”(association)	0.900
DCTN1	DCTN6	psi-mi:“MI:0914”(association)	0.780
DCTN2	DCTN6	psi-mi:“MI:0914”(association)	0.730
DCTN2	DCTN3	psi-mi:“MI:0914”(association)	0.730
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
DCTN1	DCTN3	psi-mi:“MI:0914”(association)	0.710
DYNC1I2	DYNC1LI2	psi-mi:“MI:0914”(association)	0.680
CAPZB	CNOT1	psi-mi:“MI:0914”(association)	0.640
CAPZA2	CNOT1	psi-mi:“MI:0914”(association)	0.640
DCTN5	DCTN6	psi-mi:“MI:0914”(association)	0.640
MIS18A	DCTN6	psi-mi:“MI:0914”(association)	0.640
DYNC1LI1	DYNC1LI2	psi-mi:“MI:0914”(association)	0.530
ACTBL2	POTEF	psi-mi:“MI:0914”(association)	0.530
CAPZA1	CNOT1	psi-mi:“MI:0914”(association)	0.530
DEFB127	DCTN6	psi-mi:“MI:0914”(association)	0.530
RPS19BP1	DCTN6	psi-mi:“MI:0914”(association)	0.530
PDGFD	DCTN6	psi-mi:“MI:0914”(association)	0.530
DCTN6	ZBTB43	psi-mi:“MI:0914”(association)	0.530
ACTR1A	DCTN3	psi-mi:“MI:0914”(association)	0.530
DCTN6	DCTN3	psi-mi:“MI:0914”(association)	0.530

BioGRID (186): DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Proximity Label-MS), DCTN3 (Proximity Label-MS), DCTN3 (Proximity Label-MS), DCTN3 (Affinity Capture-MS), DCTN3 (Affinity Capture-MS)

ESM2 similar proteins: A3LPQ8, C5DMF2, F1SEC0, F4IK01, O75935, O94376, P45966, P47149, P47822, P87310, P97372, Q06213, Q09248, Q09858, Q0P5A1, Q0VIA1, Q16G71, Q1HQF2, Q23679, Q28Y46, Q3ZCF2, Q4R6W4, Q5E9G3, Q5R6P5, Q61BU1, Q63798, Q68RJ5, Q6C5U8, Q6CVN3, Q6DJ25, Q6IP67, Q755V6, Q758M1, Q7K2D2, Q7PZ25, Q8I1C8, Q8I1H7, Q8LDS5, Q949S9, Q95SK3

Diamond homologs: F1SEC0, O75935, Q0P5A1, Q9Z0Y1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 99 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPI-independent Golgi-to-ER retrograde traffic	12	36.1×	1e-13
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	12	33.7×	1e-13
COPI-mediated anterograde transport	12	19.1×	8e-11
MHC class II antigen presentation	14	18.1×	3e-12
Aggrephagy	5	18.0×	1e-04
Loss of Nlp from mitotic centrosomes	7	16.1×	7e-06
Loss of proteins required for interphase microtubule organization from the centrosome	7	16.1×	7e-06
AURKA Activation by TPX2	7	15.4×	8e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitotic spindle organization	5	15.6×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1150 predictions. Top by Δscore:

Variant	Effect	Δscore
9:34617879:CATTA:C	donor_loss	1.0000
9:34617880:ATTAC:A	donor_loss	1.0000
9:34617881:TTA:T	donor_loss	1.0000
9:34617882:TACCT:T	donor_loss	1.0000
9:34617883:A:C	donor_loss	1.0000
9:34617884:C:CG	donor_loss	1.0000
9:34617884:CCTG:C	donor_gain	1.0000
9:34617967:TTCAA:T	acceptor_gain	1.0000
9:34617968:TCAA:T	acceptor_gain	1.0000
9:34617969:CAA:C	acceptor_gain	1.0000
9:34617969:CAAC:C	acceptor_gain	1.0000
9:34617970:AA:A	acceptor_gain	1.0000
9:34617970:AAC:A	acceptor_loss	1.0000
9:34617971:ACTA:A	acceptor_loss	1.0000
9:34617972:C:CC	acceptor_gain	1.0000
9:34617980:G:C	acceptor_gain	1.0000
9:34617980:G:GC	acceptor_gain	1.0000
9:34617985:A:T	acceptor_gain	1.0000
9:34618672:TTA:T	donor_loss	1.0000
9:34618673:TA:T	donor_loss	1.0000
9:34618674:A:AC	donor_gain	1.0000
9:34618674:ACT:A	donor_gain	1.0000
9:34618675:C:CT	donor_gain	1.0000
9:34618675:CT:C	donor_gain	1.0000
9:34618675:CTC:C	donor_gain	1.0000
9:34618675:CTCT:C	donor_gain	1.0000
9:34618675:CTCTT:C	donor_gain	1.0000
9:34618756:GCCAC:G	acceptor_gain	1.0000
9:34618757:CCAC:C	acceptor_gain	1.0000
9:34618757:CCACC:C	acceptor_gain	1.0000

AlphaMissense

1204 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:34613841:A:G	W168R	0.994
9:34613841:A:T	W168R	0.994
9:34613849:A:G	F165S	0.983
9:34613859:A:G	S162P	0.982
9:34617950:A:G	L68P	0.982
9:34617962:A:G	L64P	0.981
9:34614053:A:C	Y154D	0.978
9:34618704:C:A	R51S	0.977
9:34618704:C:G	R51S	0.977
9:34614053:A:G	Y154H	0.976
9:34613839:C:A	W168C	0.974
9:34613839:C:G	W168C	0.974
9:34614744:A:G	L126P	0.972
9:34613861:A:G	L161P	0.969
9:34613848:G:C	F165L	0.968
9:34613848:G:T	F165L	0.968
9:34613850:A:G	F165L	0.968
9:34614052:T:G	Y154S	0.968
9:34618698:C:A	R53S	0.967
9:34618698:C:G	R53S	0.967
9:34617893:A:T	I87N	0.965
9:34614714:T:G	Q136P	0.964
9:34618696:A:T	V54E	0.964
9:34614061:A:G	L151P	0.961
9:34613828:A:G	L172P	0.959
9:34613861:A:T	L161H	0.954
9:34616080:A:G	L101P	0.954
9:34617904:C:A	K83N	0.954
9:34617904:C:G	K83N	0.954
9:34618681:T:A	K59I	0.954

dbSNP variants (sampled 300 via entrez): RS1001062661 (9:34618484 T>C), RS1001760727 (9:34616366 T>C), RS1002036972 (9:34615607 G>A), RS1002330887 (9:34616733 G>A), RS1002741828 (9:34620236 G>A), RS1003030642 (9:34614845 G>A), RS1003074463 (9:34615017 T>G), RS1003193049 (9:34620154 G>A), RS1003801732 (9:34613216 G>T), RS1004324586 (9:34613608 G>A), RS1004918399 (9:34617191 T>C), RS1005169515 (9:34618918 C>G), RS1005274554 (9:34616971 G>A,T), RS1005508062 (9:34617138 G>A), RS1005576968 (9:34614149 T>A)

Disease associations

OMIM: gene MIM:607387 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90000025_469	Appendicular lean mass	1.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067000 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects expression, increases expression	4
bisphenol A	decreases expression	2
aristolochic acid I	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
potassium perchlorate	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases expression	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
bisphenol S	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cisplatin	increases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Vitamin E	increases expression	1
Copper Sulfate	decreases expression	1
Particulate Matter	increases abundance, decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651246	Binding	Binding affinity to human DCTN3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.