DDA1

Summary

DDA1 (DET1 and DDB1 associated 1, HGNC:28360) is a protein-coding gene on chromosome 19p13.11, encoding DET1- and DDB1-associated protein 1 (Q9BW61). Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is a selective cancer dependency (DepMap: 21.3% of cell lines).

Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex.

Source: NCBI Gene 79016 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 15 total
• Cancer dependency (DepMap): dependent in 21.3% of screened cell lines
• MANE Select transcript: NM_024050

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28360
Approved symbol	DDA1
Name	DET1 and DDB1 associated 1
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	PCIA1, MGC2594
Ensembl gene	ENSG00000130311
Ensembl biotype	protein_coding
Entrez	79016

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 3 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000359866, ENST00000593466, ENST00000594501, ENST00000596582, ENST00000596925, ENST00000858242, ENST00000935014

RefSeq mRNA: 1 — MANE Select: NM_024050 NM_024050

CCDS: CCDS12357

Canonical transcript exons

ENST00000359866 — 5 exons

Exon	Start	End
ENSE00000895505	17314338	17314389
ENSE00000895509	17315934	17315995
ENSE00001322678	17309563	17309657
ENSE00001400032	17319546	17323298
ENSE00003516491	17314023	17314103

Expression profiles

Bgee: expression breadth ubiquitous, 241 present calls, max score 96.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 67.1690 / max 288.0773, expressed in 1825 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174493	67.1690	1825

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	96.60	gold quality
cingulate cortex	UBERON:0003027	96.53	gold quality
prefrontal cortex	UBERON:0000451	96.51	gold quality
left testis	UBERON:0004533	96.29	gold quality
right testis	UBERON:0004534	96.17	gold quality
monocyte	CL:0000576	96.09	gold quality
mononuclear cell	CL:0000842	95.97	gold quality
right frontal lobe	UBERON:0002810	95.83	gold quality
stromal cell of endometrium	CL:0002255	95.47	gold quality
leukocyte	CL:0000738	95.41	gold quality
amygdala	UBERON:0001876	95.06	gold quality
mucosa of transverse colon	UBERON:0004991	94.77	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.60	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.51	gold quality
nucleus accumbens	UBERON:0001882	94.29	gold quality
frontal cortex	UBERON:0001870	94.24	gold quality
testis	UBERON:0000473	94.05	gold quality
hypothalamus	UBERON:0001898	94.02	gold quality
caudate nucleus	UBERON:0001873	93.99	gold quality
apex of heart	UBERON:0002098	93.96	gold quality
popliteal artery	UBERON:0002250	93.92	gold quality
tibial artery	UBERON:0007610	93.92	gold quality
neocortex	UBERON:0001950	93.91	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.83	gold quality
left adrenal gland	UBERON:0001234	93.71	gold quality
right adrenal gland cortex	UBERON:0035827	93.61	gold quality
aorta	UBERON:0000947	93.60	gold quality
left coronary artery	UBERON:0001626	93.52	gold quality
adult organism	UBERON:0007023	93.51	gold quality
thoracic aorta	UBERON:0001515	93.48	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.95
E-MTAB-6386	no	192.56
E-GEOD-110499	no	106.26
E-GEOD-125970	no	3.40

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

150 targeting DDA1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 21.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• PCIA1 gene expression correlates with tumor formation, invasion and metastasis (PMID:17557237)
• Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with cullin-RING E3 ligases complexes. (PMID:19295130)
• Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway. (PMID:26942699)
• the c-Abl non-receptor kinase phosphorylates DDB1 at residue Tyr-316 to recruit a small regulatory protein, DDA1, leading to increased substrate ubiquitination (PMID:28087699)
• The results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression. (PMID:28211159)
• surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis (PMID:29166600)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dda1	ENSDARG00000076074
mus_musculus	Dda1	ENSMUSG00000074247
rattus_norvegicus	Dda1	ENSRNOG00000039417
drosophila_melanogaster	CG31855	FBGN0051855

Protein

Protein identifiers

DET1- and DDB1-associated protein 1 — Q9BW61 (reviewed: Q9BW61)

Alternative names: Placenta cross-immune reaction antigen 1

All UniProt accessions (1): Q9BW61

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.

Subunit / interactions. Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Part of the DDD core complex containing DET1, DDA1 and DDB1; the DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the DDA1 family.

RefSeq proteins (1): NP_076955* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018276	DDA1_dom	Domain
IPR033575	DDA1-like	Family

Pfam: PF10172

UniProt features (15 total): turn 3, modified residue 3, helix 2, strand 2, compositionally biased region 2, initiator methionine 1, chain 1, region of interest 1

Structure

Experimental structures (PDB)

30 structures.

PDB	Method	Resolution (Å)
9BZ0	ELECTRON MICROSCOPY	1.9
8G46	ELECTRON MICROSCOPY	2.2
6UD7	X-RAY DIFFRACTION	2.3
6UE5	X-RAY DIFFRACTION	2.61
8TL6	ELECTRON MICROSCOPY	2.63
9LTJ	ELECTRON MICROSCOPY	2.65
9BJZ	ELECTRON MICROSCOPY	2.83
6PAI	X-RAY DIFFRACTION	2.9
6Q0R	X-RAY DIFFRACTION	2.9
6Q0V	X-RAY DIFFRACTION	2.9
6Q0W	X-RAY DIFFRACTION	2.9
9DHD	ELECTRON MICROSCOPY	2.9
9LTO	ELECTRON MICROSCOPY	2.92
9LTL	ELECTRON MICROSCOPY	2.93
9LTR	ELECTRON MICROSCOPY	3.03
9C5U	ELECTRON MICROSCOPY	3.05
6DSZ	X-RAY DIFFRACTION	3.09
8ROY	ELECTRON MICROSCOPY	3.1
9LTW	ELECTRON MICROSCOPY	3.25
9LTZ	ELECTRON MICROSCOPY	3.26
8ROX	ELECTRON MICROSCOPY	3.3
9S3R	ELECTRON MICROSCOPY	3.3
9C5V	ELECTRON MICROSCOPY	3.36
8QH5	ELECTRON MICROSCOPY	3.4
9FD2	ELECTRON MICROSCOPY	3.4
6SJ7	ELECTRON MICROSCOPY	3.54
9LU1	ELECTRON MICROSCOPY	3.62
9W90	ELECTRON MICROSCOPY	3.7
9M0Y	ELECTRON MICROSCOPY	4.25
9LUL	ELECTRON MICROSCOPY	4.99

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BW61-F1	67.25	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 2, 33, 95

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8951664	Neddylation

MSigDB gene sets: 167 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS, MODULE_169, GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GTTAAAG_MIR302B, GGGTGGRR_PAX4_03, RICKMAN_METASTASIS_DN, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS, GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

GO Biological Process (4): protein polyubiquitination (GO:0000209), positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436), protein ubiquitination (GO:0016567), regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): nucleoplasm (GO:0005654), Cul4-RING E3 ubiquitin ligase complex (GO:0080008)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
proteasome-mediated ubiquitin-dependent protein catabolic process	2
protein ubiquitination	1
regulation of proteasomal ubiquitin-dependent protein catabolic process	1
positive regulation of proteasomal protein catabolic process	1
positive regulation of ubiquitin-dependent protein catabolic process	1
protein modification by small protein conjugation	1
regulation of proteasomal protein catabolic process	1
regulation of ubiquitin-dependent protein catabolic process	1
binding	1
nuclear lumen	1
cellular anatomical structure	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

774 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DDA1	DDB1	Q16531	992
DDA1	DET1	Q7L5Y6	978
DDA1	CUL4A	Q13619	970
DDA1	DCAF15	Q66K64	832
DDA1	CUL4B	Q13620	821
DDA1	RBM39	Q14498	771
DDA1	DCAF1	Q9Y4B6	745
DDA1	RBX1	P62877	559
DDA1	HLTF	Q14527	478
DDA1	GPATCH8	Q9UKJ3	475
DDA1	ENY2	Q9NPA8	449
DDA1	EME2	A4GXA9	444
DDA1	DCAF17	Q5H9S7	425
DDA1	MUS81	Q96NY9	418
DDA1	TET2	Q6N021	376

IntAct

158 interactions, top by confidence:

A	B	Type	Score
FOSL2	JUN	psi-mi:“MI:0914”(association)	0.930
LLGL2	PRKCI	psi-mi:“MI:0914”(association)	0.890
CUL4B	COPS2	psi-mi:“MI:0914”(association)	0.790
DDA1	DDB1	psi-mi:“MI:0407”(direct interaction)	0.780
RFXANK	RFXAP	psi-mi:“MI:0914”(association)	0.780
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
CUL4A	COPS2	psi-mi:“MI:0914”(association)	0.640
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
DDA1	AGTRAP	psi-mi:“MI:0915”(physical association)	0.560
DDA1	CMTM5	psi-mi:“MI:0915”(physical association)	0.560
CMTM5	DDA1	psi-mi:“MI:0915”(physical association)	0.560
PKNOX2	DDA1	psi-mi:“MI:0915”(physical association)	0.560
RDH10	DDA1	psi-mi:“MI:0915”(physical association)	0.560
PRKN	DDA1	psi-mi:“MI:0915”(physical association)	0.560
DCAF11	GNPAT	psi-mi:“MI:0914”(association)	0.530
PRKCZ	IPO5	psi-mi:“MI:0914”(association)	0.530

BioGRID (758): DDB1 (Affinity Capture-Western), CUL4A (Affinity Capture-Western), CUL4B (Affinity Capture-Western), DDA1 (Two-hybrid), CMTM5 (Two-hybrid), DDA1 (Affinity Capture-Western), DDA1 (Affinity Capture-Western), DDA1 (Affinity Capture-Western), DET1 (Affinity Capture-Western), DDA1 (Affinity Capture-MS), DDA1 (Affinity Capture-MS), DDB1 (Co-fractionation), VPRBP (Co-fractionation), DDA1 (Two-hybrid), DDA1 (Affinity Capture-MS)

ESM2 similar proteins: A3CEM4, A6NGY3, A9CB88, B2ZCQ0, B3LVF9, B3P0Q4, B4HEN5, B4K843, B4LY66, B4N943, B4PST7, B4QZV5, C9K7C7, F4KIH4, O16224, O41804, O70903, O89085, O89945, O91087, P03238, P0A3T0, P0A3T1, P12597, P13623, P24103, P27970, P28953, P28989, P33632, P36356, P36713, P50785, P55924, P56280, P85112, Q09340, Q09410, Q12379, Q5E9A9

Diamond homologs: Q5BL73, Q5E9A9, Q5RD86, Q5U550, Q5ZK14, Q7T2A3, Q9BW61, Q9D9Z5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 173 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
DNA Damage Recognition in GG-NER	10	25.5×	1e-09
Formation of TC-NER Pre-Incision Complex	10	18.9×	2e-08
Recognition of DNA damage by PCNA-containing replication complex	5	17.0×	1e-03
Dual Incision in GG-NER	6	13.9×	7e-04
Formation of Incision Complex in GG-NER	6	13.6×	7e-04
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	5	11.9×	5e-03
Neddylation	26	11.0×	2e-17
Dual incision in TC-NER	6	9.3×	4e-03

GO biological processes:

GO term	Partners	Fold	FDR
regulation of protein neddylation	5	30.8×	1e-04
protein neddylation	5	23.1×	4e-04
protein ubiquitination	34	9.3×	2e-20
proteasome-mediated ubiquitin-dependent protein catabolic process	20	6.9×	6e-09
protein polyubiquitination	9	6.8×	9e-04
ubiquitin-dependent protein catabolic process	11	5.4×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

15 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	13
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

547 predictions. Top by Δscore:

Variant	Effect	Δscore
19:17309654:GATG:G	donor_gain	1.0000
19:17309655:ATGG:A	donor_loss	1.0000
19:17309656:TGGT:T	donor_loss	1.0000
19:17309657:GGT:G	donor_loss	1.0000
19:17309663:G:GT	donor_gain	1.0000
19:17314021:A:AG	acceptor_gain	1.0000
19:17314021:AGGC:A	acceptor_loss	1.0000
19:17314022:G:GG	acceptor_gain	1.0000
19:17314022:GGC:G	acceptor_gain	1.0000
19:17314022:GGCA:G	acceptor_gain	1.0000
19:17314104:G:GG	donor_gain	1.0000
19:17314104:GTGA:G	donor_loss	1.0000
19:17314336:A:AG	acceptor_gain	1.0000
19:17314337:G:GT	acceptor_gain	1.0000
19:17314337:GA:G	acceptor_gain	1.0000
19:17314337:GAACC:G	acceptor_gain	1.0000
19:17314388:GA:G	donor_gain	1.0000
19:17314390:G:GG	donor_gain	1.0000
19:17315996:G:GA	donor_loss	1.0000
19:17315997:T:G	donor_loss	1.0000
19:17319536:T:A	acceptor_gain	1.0000
19:17319542:CCAG:C	acceptor_loss	1.0000
19:17319544:A:AG	acceptor_gain	1.0000
19:17319544:AGA:A	acceptor_loss	1.0000
19:17319544:AGAAC:A	acceptor_gain	1.0000
19:17319545:G:GG	acceptor_gain	1.0000
19:17319545:GA:G	acceptor_gain	1.0000
19:17319545:GAA:G	acceptor_gain	1.0000
19:17319545:GAAC:G	acceptor_gain	1.0000
19:17319545:GAACG:G	acceptor_gain	1.0000

AlphaMissense

665 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:17315937:T:A	I47N	1.000
19:17315937:T:G	I47S	1.000
19:17315946:A:T	E50V	1.000
19:17315958:T:A	I54N	1.000
19:17315958:T:C	I54T	1.000
19:17315958:T:G	I54S	1.000
19:17315961:T:A	L55H	1.000
19:17315961:T:C	L55P	1.000
19:17315964:T:A	L56Q	1.000
19:17315964:T:C	L56P	1.000
19:17315966:C:A	R57S	1.000
19:17315969:T:G	Y58D	1.000
19:17315973:T:A	L59Q	1.000
19:17315973:T:C	L59P	1.000
19:17314042:T:C	L8P	0.999
19:17314065:T:C	F16L	0.999
19:17314066:T:C	F16S	0.999
19:17314067:T:A	F16L	0.999
19:17314067:T:G	F16L	0.999
19:17314356:T:G	Y35D	0.999
19:17315937:T:C	I47T	0.999
19:17315956:C:A	N53K	0.999
19:17315956:C:G	N53K	0.999
19:17315957:A:T	I54F	0.999
19:17315966:C:G	R57G	0.999
19:17315967:G:C	R57P	0.999
19:17315970:A:C	Y58S	0.999
19:17315975:C:G	H60D	0.999
19:17315979:A:C	Q61P	0.999
19:17315982:A:C	Q62P	0.999

dbSNP variants (sampled 300 via entrez): RS1000018641 (19:17312285 G>T), RS1000310237 (19:17309251 A>T), RS1000345753 (19:17314047 G>A), RS1000689099 (19:17312932 G>A), RS1000760897 (19:17313259 G>A,C), RS1001273889 (19:17318548 G>A), RS1001381720 (19:17307941 C>G), RS1001424651 (19:17313205 G>A), RS1001478947 (19:17313713 G>A), RS1001551197 (19:17313965 T>C), RS1001705172 (19:17318241 A>G,T), RS1001737667 (19:17323540 A>G), RS1001771880 (19:17323275 CAA>C), RS1001772206 (19:17308183 G>A), RS1001888098 (19:17312850 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001795_14	Systemic lupus erythematosus	1.000000e-06
GCST007394_2	Mitochondrial DNA copy number	1.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006312	mitochondrial DNA measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	increases expression	2
Valproic Acid	decreases methylation, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	decreases methylation	1
beta-lapachone	increases expression	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
bisphenol S	increases expression, affects cotreatment	1
Resveratrol	decreases expression, affects cotreatment	1
Temozolomide	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Methotrexate	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.