DDIT4-AS1

Summary

DDIT4-AS1 (DDIT4 antisense RNA 1, HGNC:52379) is a long non-coding RNA gene on chromosome 10q22.1.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52379
Approved symbol	DDIT4-AS1
Name	DDIT4 antisense RNA 1
Location	10q22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-442H21.2
Ensembl gene	ENSG00000269926
Entrez	110806271
RNAcentral	URS00026A1AB5 — lncRNA, 2326 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 93.10.

Top tissues by expression

142 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	93.10	gold quality
skeletal muscle tissue	UBERON:0001134	91.33	gold quality
epithelium of bronchus	UBERON:0002031	89.88	gold quality
vermiform appendix	UBERON:0001154	89.22	gold quality
islet of Langerhans	UBERON:0000006	88.95	gold quality
pancreas	UBERON:0001264	86.71	gold quality
tonsil	UBERON:0002372	86.63	gold quality
ganglionic eminence	UBERON:0004023	84.29	gold quality
body of pancreas	UBERON:0001150	84.22	gold quality
gall bladder	UBERON:0002110	84.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.99	gold quality
colonic epithelium	UBERON:0000397	83.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.03	gold quality
granulocyte	CL:0000094	82.46	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.32	gold quality
lymph node	UBERON:0000029	81.27	gold quality
placenta	UBERON:0001987	81.16	gold quality
stromal cell of endometrium	CL:0002255	81.12	gold quality
cortical plate	UBERON:0005343	80.63	gold quality
bone marrow	UBERON:0002371	79.29	gold quality
bone marrow cell	CL:0002092	79.24	gold quality
smooth muscle tissue	UBERON:0001135	79.08	gold quality
liver	UBERON:0002107	78.95	gold quality
calcaneal tendon	UBERON:0003701	78.27	gold quality
fallopian tube	UBERON:0003889	78.24	gold quality
adrenal tissue	UBERON:0018303	78.04	gold quality
rectum	UBERON:0001052	77.36	gold quality
apex of heart	UBERON:0002098	77.14	gold quality
prefrontal cortex	UBERON:0000451	76.85	gold quality
leukocyte	CL:0000738	76.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The m(6)A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway. (PMID:36056355)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr10q22

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

129 predictions. Top by Δscore:

Variant	Effect	Δscore
10:72274417:GGAAG:G	donor_gain	1.0000
10:72274418:G:GT	donor_gain	1.0000
10:72274419:A:T	donor_gain	1.0000
10:72274420:AGG:A	donor_loss	1.0000
10:72274421:GGTGA:G	donor_loss	1.0000
10:72274423:T:G	donor_loss	1.0000
10:72274680:T:TA	acceptor_gain	1.0000
10:72274690:TCCAG:T	acceptor_loss	1.0000
10:72274691:CCA:C	acceptor_loss	1.0000
10:72274692:CAG:C	acceptor_loss	1.0000
10:72274693:A:AG	acceptor_gain	1.0000
10:72274693:A:T	acceptor_loss	1.0000
10:72274694:G:A	acceptor_loss	1.0000
10:72274694:G:GA	acceptor_gain	1.0000
10:72274694:GA:G	acceptor_gain	1.0000
10:72274694:GAC:G	acceptor_gain	1.0000
10:72274694:GACA:G	acceptor_gain	1.0000
10:72274694:GACAC:G	acceptor_gain	1.0000
10:72274155:A:AG	acceptor_gain	0.9900
10:72274155:AGC:A	acceptor_gain	0.9900
10:72274156:G:GG	acceptor_gain	0.9900
10:72274156:GC:G	acceptor_gain	0.9900
10:72274156:GCG:G	acceptor_gain	0.9900
10:72274422:G:GG	donor_gain	0.9900
10:72274678:T:TA	acceptor_gain	0.9900
10:72274057:GCTG:G	donor_gain	0.9800
10:72274155:AGCG:A	acceptor_gain	0.9800
10:72274156:GCGG:G	acceptor_gain	0.9800
10:72274156:GCGGC:G	acceptor_gain	0.9800
10:72274418:GAAG:G	donor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	1
dimethylselenide	decreases expression, increases oxidation, increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
Lipopolysaccharides	increases expression, affects response to substance	1
Ozone	decreases expression, increases oxidation	1
Reactive Oxygen Species	increases expression, decreases expression, increases oxidation	1
Hydroxyl Radical	decreases expression, increases oxidation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.