DDN-AS1

Summary

DDN-AS1 (DDN and PRKAG1 antisense RNA 1, HGNC:53464) is a long non-coding RNA gene on chromosome 12q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53464
Approved symbol	DDN-AS1
Name	DDN and PRKAG1 antisense RNA 1
Location	12q13.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	CAT1507
Ensembl gene	ENSG00000257913
Ensembl biotype	lncRNA
Entrez	105369758
RNAcentral	URS0000BC4562 — lncRNA, 1430 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000547395, ENST00000547866, ENST00000552284, ENST00000552933, ENST00000691225

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000547395 — 3 exons

Exon	Start	End
ENSE00002357176	49018236	49018719
ENSE00002404131	48998398	48998690
ENSE00002427702	49009309	49009389

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 89.76.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1981 / max 30.2663, expressed in 458 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
125292	1.1361	448
125291	0.0620	26

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.15	silver quality
nucleus accumbens	UBERON:0001882	78.88	gold quality
putamen	UBERON:0001874	77.32	gold quality
caudate nucleus	UBERON:0001873	76.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.30	gold quality
anterior cingulate cortex	UBERON:0009835	72.94	gold quality
right frontal lobe	UBERON:0002810	72.93	gold quality
bone marrow cell	CL:0002092	72.04	silver quality
cerebral cortex	UBERON:0000956	70.93	gold quality
pituitary gland	UBERON:0000007	70.37	gold quality
frontal cortex	UBERON:0001870	70.09	gold quality
primary visual cortex	UBERON:0002436	69.58	gold quality
adenohypophysis	UBERON:0002196	69.42	gold quality
gastrocnemius	UBERON:0001388	68.92	gold quality
brain	UBERON:0000955	68.46	gold quality
muscle of leg	UBERON:0001383	68.30	gold quality
prefrontal cortex	UBERON:0000451	68.21	gold quality
temporal lobe	UBERON:0001871	67.92	gold quality
amygdala	UBERON:0001876	67.90	gold quality
superior frontal gyrus	UBERON:0002661	67.70	gold quality
Ammon’s horn	UBERON:0001954	66.73	gold quality
apex of heart	UBERON:0002098	66.41	gold quality
bone marrow	UBERON:0002371	65.94	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.80	gold quality
skeletal muscle tissue	UBERON:0001134	64.88	gold quality
granulocyte	CL:0000094	64.20	gold quality
muscle tissue	UBERON:0002385	63.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Findings indicate that long noncoding RNA DDN and PRKAG1 antisense RNA 1 (DDN-AS1)-miR-15a/16-transcription activator transcription factor 3 (TCF3) feedback loop contributes to cell proliferation, migration, and invasion in cervical cancer (CC). (PMID:30582201)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.