DDX11-AS1

Summary

DDX11-AS1 (DDX11 antisense RNA 1, HGNC:44176) is a long non-coding RNA gene on chromosome 12p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44176
Approved symbol	DDX11-AS1
Name	DDX11 antisense RNA 1
Location	12p11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	CONCR, SCAT4
Ensembl gene	ENSG00000245614
Ensembl biotype	lncRNA
Entrez	100506660
RNAcentral	URS000075B070 — lncRNA, 2031 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000500527, ENST00000535870, ENST00000618041, ENST00000669174, ENST00000685910, ENST00000701923

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500527 — 3 exons

Exon	Start	End
ENSE00001967127	31020763	31022029
ENSE00001988105	31073195	31073847
ENSE00001988886	31060660	31060770

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 70.18.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5143 / max 11.2075, expressed in 323 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130332	0.5143	323

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.18	gold quality
ventricular zone	UBERON:0003053	69.57	gold quality
bone marrow cell	CL:0002092	69.33	gold quality
ganglionic eminence	UBERON:0004023	68.95	gold quality
stromal cell of endometrium	CL:0002255	67.02	gold quality
apex of heart	UBERON:0002098	66.98	gold quality
mucosa of transverse colon	UBERON:0004991	65.18	gold quality
cortical plate	UBERON:0005343	64.64	gold quality
adrenal tissue	UBERON:0018303	63.17	gold quality
tibial nerve	UBERON:0001323	61.27	gold quality
smooth muscle tissue	UBERON:0001135	60.47	gold quality
left ovary	UBERON:0002119	59.80	gold quality
lymph node	UBERON:0000029	59.35	gold quality
endocervix	UBERON:0000458	59.20	gold quality
islet of Langerhans	UBERON:0000006	58.93	gold quality
right ovary	UBERON:0002118	58.82	gold quality
metanephros cortex	UBERON:0010533	58.81	gold quality
cortex of kidney	UBERON:0001225	58.80	gold quality
right adrenal gland cortex	UBERON:0035827	58.77	gold quality
prefrontal cortex	UBERON:0000451	58.70	gold quality
muscle of leg	UBERON:0001383	58.61	gold quality
gastrocnemius	UBERON:0001388	58.41	gold quality
rectum	UBERON:0001052	58.32	gold quality
right adrenal gland	UBERON:0001233	57.79	gold quality
right atrium auricular region	UBERON:0006631	57.51	gold quality
ectocervix	UBERON:0012249	57.40	gold quality
cardiac atrium	UBERON:0002081	57.07	gold quality
ovary	UBERON:0000992	57.01	gold quality
tibial artery	UBERON:0007610	56.69	gold quality
popliteal artery	UBERON:0002250	56.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• lncRNA CONCR has direct role in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activity. (PMID:27477908)
• Long noncoding RNA DDX11-AS1 induced by YY1 accelerates colorectal cancer progression through targeting miR-873/CLDN7 axis. (PMID:31298324)
• Long non-coding RNA DDX11-AS1 promotes non-small cell lung cancer development via regulating PI3K/AKT signalling. (PMID:32298476)
• LncRNA DDX11-AS1 Promotes Bladder Cancer Occurrence Via Protecting LAMB3 from Downregulation by Sponging miR-2355-5p. (PMID:32412777)
• Long non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis. (PMID:34281459)
• Landscape analysis of lncRNAs shows that DDX11-AS1 promotes cell-cycle progression in liver cancer through the PARP1/p53 axis. (PMID:34371129)
• LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/beta-catenin pathway. (PMID:34866524)
• Knockdown of long noncoding RNA DDX11AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA497 expression. (PMID:35169864)
• LncRNA DDX11-AS1 Promotes Chemoresistance through LIN28A-Mediated ATG12 mRNA Stabilization in Breast Cancer. (PMID:36382664)
• DDX11-AS1 modulates DNA damage repair to enhance paclitaxel resistance of lung adenocarcinoma cells. (PMID:36779347)
• Accessory Gene Regulator (agr) group polymorphisms in methicillin-resistant Staphylococcus aureus and its association with biofilm formation. (PMID:38678634)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.