DDX19A

Summary

DDX19A (DEAD-box helicase 19A, HGNC:25628) is a protein-coding gene on chromosome 16q22.1, encoding ATP-dependent RNA helicase DDX19A (Q9NUU7). ATP-dependent RNA helicase involved in mRNA export from the nucleus. It is a selective cancer dependency (DepMap: 22.2% of cell lines).

Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in membrane.

Source: NCBI Gene 55308 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 46 total
• Cancer dependency (DepMap): dependent in 22.2% of screened cell lines
• MANE Select transcript: NM_018332

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25628
Approved symbol	DDX19A
Name	DEAD-box helicase 19A
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11126
Ensembl gene	ENSG00000168872
Ensembl biotype	protein_coding
Entrez	55308

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 10 protein_coding, 5 nonsense_mediated_decay, 5 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000302243, ENST00000417604, ENST00000561574, ENST00000562140, ENST00000562509, ENST00000562649, ENST00000565195, ENST00000566167, ENST00000566574, ENST00000567012, ENST00000568779, ENST00000569244, ENST00000569319, ENST00000569771, ENST00000575878, ENST00000879410, ENST00000921894, ENST00000921895, ENST00000921896, ENST00000950912, ENST00000950913, ENST00000950914

RefSeq mRNA: 5 — MANE Select: NM_018332 NM_001320522, NM_001320525, NM_001320526, NM_001320527, NM_018332

CCDS: CCDS10889, CCDS82009

Canonical transcript exons

ENST00000302243 — 12 exons

Exon	Start	End
ENSE00001878419	70346903	70347048
ENSE00002622974	70371925	70373383
ENSE00003495648	70356112	70356247
ENSE00003598141	70355485	70355535
ENSE00003685600	70350557	70350605
ENSE00003784604	70366624	70366861
ENSE00003784856	70361418	70361510
ENSE00003785046	70365017	70365131
ENSE00003787422	70370223	70370385
ENSE00003788219	70366085	70366262
ENSE00003790889	70364543	70364645
ENSE00003791517	70371372	70371563

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 94.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.1091 / max 325.3243, expressed in 1820 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154871	36.7988	1819
154872	2.0803	1255
207933	0.2300	80

Top tissues by expression

151 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	94.42	gold quality
muscle of leg	UBERON:0001383	94.20	gold quality
skeletal muscle tissue	UBERON:0001134	93.05	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.64	gold quality
smooth muscle tissue	UBERON:0001135	92.40	gold quality
muscle tissue	UBERON:0002385	92.20	gold quality
placenta	UBERON:0001987	91.35	gold quality
adrenal tissue	UBERON:0018303	90.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.62	gold quality
lower esophagus	UBERON:0013473	90.59	gold quality
popliteal artery	UBERON:0002250	90.57	gold quality
tibial artery	UBERON:0007610	90.57	gold quality
ventricular zone	UBERON:0003053	90.54	gold quality
right coronary artery	UBERON:0001625	90.53	gold quality
urinary bladder	UBERON:0001255	90.29	gold quality
sural nerve	UBERON:0015488	90.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	90.22	gold quality
vastus lateralis	UBERON:0001379	89.96	silver quality
islet of Langerhans	UBERON:0000006	89.83	gold quality
calcaneal tendon	UBERON:0003701	89.81	gold quality
descending thoracic aorta	UBERON:0002345	89.74	gold quality
muscle layer of sigmoid colon	UBERON:0035805	89.71	gold quality
thoracic aorta	UBERON:0001515	89.67	gold quality
ascending aorta	UBERON:0001496	89.59	gold quality
sigmoid colon	UBERON:0001159	89.55	gold quality
right adrenal gland cortex	UBERON:0035827	89.55	gold quality
mucosa of stomach	UBERON:0001199	89.54	gold quality
left uterine tube	UBERON:0001303	89.43	gold quality
left adrenal gland	UBERON:0001234	89.34	gold quality
heart left ventricle	UBERON:0002084	89.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.75

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

55 targeting DDX19A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-3662	99.99	73.82	5684
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-MIR-98-5P	99.98	72.33	1787
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-1255A	99.74	68.09	744
HSA-MIR-1255B-5P	99.74	68.16	741
HSA-MIR-1296-3P	99.72	64.04	636
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-3616-5P	99.55	67.02	989
HSA-MIR-573	99.55	67.44	955

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 22.2% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A. (PMID:34612147)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	ddx19b	ENSDARG00000005699
danio_rerio	ddx19a	ENSDARG00000044325
mus_musculus	Ddx19a	ENSMUSG00000015023
rattus_norvegicus	Ddx19b	ENSRNOG00000018033

Paralogs (38): DDX20 (ENSG00000064703), DDX3Y (ENSG00000067048), DDX1 (ENSG00000079785), DDX43 (ENSG00000080007), DDX18 (ENSG00000088205), DDX24 (ENSG00000089737), DDX17 (ENSG00000100201), DDX49 (ENSG00000105671), DDX50 (ENSG00000107625), DDX5 (ENSG00000108654), DDX25 (ENSG00000109832), DDX6 (ENSG00000110367), DDX55 (ENSG00000111364), DDX59 (ENSG00000118197), DDX54 (ENSG00000123064), DDX39A (ENSG00000123136), DDX27 (ENSG00000124228), DDX31 (ENSG00000125485), DDX56 (ENSG00000136271), EIF4A3 (ENSG00000141543), DDX46 (ENSG00000145833), DDX4 (ENSG00000152670), EIF4A2 (ENSG00000156976), DDX19B (ENSG00000157349), EIF4A1 (ENSG00000161960), DDX21 (ENSG00000165732), TDRD12 (ENSG00000173809), DDX23 (ENSG00000174243), DDX10 (ENSG00000178105), DDX28 (ENSG00000182810), DDX41 (ENSG00000183258), DDX53 (ENSG00000184735), DDX51 (ENSG00000185163), DDX42 (ENSG00000198231), DDX39B (ENSG00000198563), DDX47 (ENSG00000213782), DDX3X (ENSG00000215301), DDX52 (ENSG00000278053)

Protein

Protein identifiers

ATP-dependent RNA helicase DDX19A — Q9NUU7 (reviewed: Q9NUU7)

Alternative names: DDX19-like protein, DEAD box protein 19A

All UniProt accessions (8): Q9NUU7, H3BP36, H3BP50, H3BSL8, H3BTB3, I3L0H8, I3L352, J3QRH0

UniProt curated annotations — full annotation on UniProt →

Function. ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

Subcellular location. Cytoplasm. Nucleus. Nucleoplasm.

Domain organisation. The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.

Similarity. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NUU7-1	1	yes
Q9NUU7-2	2

RefSeq proteins (5): NP_001307451, NP_001307454, NP_001307455, NP_001307456, NP_060802* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001650	Helicase_C-like	Domain
IPR011545	DEAD/DEAH_box_helicase_dom	Domain
IPR014001	Helicase_ATP-bd	Domain
IPR014014	RNA_helicase_DEAD_Q_motif	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00270, PF00271

Catalyzed reactions (Rhea), 1 shown:

• ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)

UniProt features (19 total): binding site 4, region of interest 3, modified residue 2, cross-link 2, domain 2, short sequence motif 2, initiator methionine 1, chain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NUU7-F1	80.97	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 137–144; 428; 431; 118

Post-translational modifications (4): 2, 42, 26, 26

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 172 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN, ATF_B, ACTACCT_MIR196A_MIR196B, FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN, chr16q22, SHEPARD_CRASH_AND_BURN_MUTANT_UP, MORF_HDAC1, MORF_UBE2N, CREBP1_Q2, MORF_HDAC2, MODULE_16, GOBP_NUCLEAR_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN, CREB_Q2_01

GO Biological Process (3): response to zinc ion (GO:0010043), poly(A)+ mRNA export from nucleus (GO:0016973), positive regulation of apoptotic process (GO:0043065)

GO Molecular Function (10): RNA helicase activity (GO:0003724), mRNA binding (GO:0003729), ATP binding (GO:0005524), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), nucleic acid binding (GO:0003676), RNA binding (GO:0003723), helicase activity (GO:0004386), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasmic stress granule (GO:0010494), membrane (GO:0016020), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
ATP-dependent activity	2
binding	2
response to metal ion	1
mRNA export from nucleus	1
apoptotic process	1
regulation of apoptotic process	1
positive regulation of programmed cell death	1
helicase activity	1
ATP-dependent activity, acting on RNA	1
catalytic activity, acting on RNA	1
RNA binding	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
nucleic acid binding	1
nucleic acid conformation isomerase activity	1
catalytic activity, acting on a nucleic acid	1
catalytic activity	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasmic ribonucleoprotein granule	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1616 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DDX19A	NLRP3	Q96P20	825
DDX19A	DHX33	Q9H6R0	572
DDX19A	ANGEL1	Q9UNK9	512
DDX19A	GLE1	Q53GS7	501
DDX19A	DHX57	Q6P158	450
DDX19A	OR2T5	Q6IEZ7	439
DDX19A	RNF19A	Q9NV58	425
DDX19A	TUBGCP3	Q96CW5	417
DDX19A	GEMIN2	O14893	413
DDX19A	DHX36	Q9H2U1	410
DDX19A	TUBG1	P23258	407
DDX19A	BMP8A	Q7Z5Y6	401
DDX19A	NAGA	P17050	398
DDX19A	BMP8B	P34820	382
DDX19A	NUP214	P35658	381

IntAct

81 interactions, top by confidence:

A	B	Type	Score
DDX19B	MIF4GD	psi-mi:“MI:0914”(association)	0.870
MIF4GD	DDX19A	psi-mi:“MI:0915”(physical association)	0.860
DDX19A	MIF4GD	psi-mi:“MI:0915”(physical association)	0.860
DDX19A	MIF4GD	psi-mi:“MI:0914”(association)	0.860
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
CTIF	DDX19A	psi-mi:“MI:0915”(physical association)	0.670
DDX19A	CFTR	psi-mi:“MI:0915”(physical association)	0.620
CFTR	DDX19A	psi-mi:“MI:0915”(physical association)	0.620
MIF4GD	DDX19A	psi-mi:“MI:0915”(physical association)	0.560
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
SDC2	DDX19A	psi-mi:“MI:0915”(physical association)	0.400
DDX19A	PA	psi-mi:“MI:0915”(physical association)	0.370
DDX19A	PB1	psi-mi:“MI:0915”(physical association)	0.370
DDX19A	PB2	psi-mi:“MI:0915”(physical association)	0.370
MDFI	DDX19A	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
HSD17B10	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
HSD17B10	HNRNPDL	psi-mi:“MI:0914”(association)	0.350
HSD17B10	COPE	psi-mi:“MI:0914”(association)	0.350

BioGRID (126): MIF4GD (Two-hybrid), DDX19A (Affinity Capture-RNA), DDX19A (Affinity Capture-MS), DDX19A (Two-hybrid), DDX25 (Affinity Capture-MS), DDX19B (Affinity Capture-MS), NUP214 (Affinity Capture-MS), NUP88 (Affinity Capture-MS), NUP62 (Affinity Capture-MS), CTIF (Affinity Capture-MS), MIF4GD (Two-hybrid), DDX19A (Co-fractionation), DDX19A (Co-fractionation), DDX19A (Co-fractionation), DDX19A (Co-fractionation)

ESM2 similar proteins: A1CFV3, A1CYG5, A3GH91, A3LNR6, A4R8B5, A4RIF1, A5DBI5, A5DID7, A5DZX2, A6RC50, A6SBT4, A6ZNQ1, A7EY76, O61305, P0CQ84, P0CQ86, P0CQ87, P20449, Q03532, Q09747, Q0CDT1, Q0UCB9, Q0UR48, Q1EB85, Q2HGF7, Q2U8K6, Q2UUN6, Q3ZBV2, Q4HY71, Q4IEK8, Q4P7Z8, Q4WIN6, Q5AJD0, Q5AK59, Q5AVM1, Q5BBY1, Q61655, Q6BH93, Q6BRE4, Q6C3X7

Diamond homologs: A1CFV3, A1CJT5, A1CYG5, A1D7N3, A2QEN5, A2QUY7, A3GFI4, A3GH91, A4HRK0, A4QVP2, A4RIF1, A5A6N4, A5DB98, A5DBI5, A5DVM3, A5DZX2, A6RC50, A6RJ45, A6SBT4, A6ZNQ1, A6ZQJ1, A7EGL7, A7EY76, O02494, O61305, O62591, P0CQ70, P0CQ71, P0CQ86, P0CQ87, P10081, P10630, P20449, P27639, P29562, P35683, P41376, P41378, P41379, P41381

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 83 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
cell surface receptor protein tyrosine kinase signaling pathway	7	17.9×	7e-05
protein autophosphorylation	6	12.8×	2e-03
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	7	8.1×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2282 predictions. Top by Δscore:

Variant	Effect	Δscore
16:70347031:G:GT	donor_gain	1.0000
16:70347045:GTCG:G	donor_gain	1.0000
16:70347076:G:GT	donor_gain	1.0000
16:70347116:G:GT	donor_gain	1.0000
16:70350551:A:AG	acceptor_gain	1.0000
16:70350552:T:G	acceptor_gain	1.0000
16:70350552:TTCA:T	acceptor_loss	1.0000
16:70350553:TCA:T	acceptor_loss	1.0000
16:70350554:CA:C	acceptor_loss	1.0000
16:70350555:A:AG	acceptor_gain	1.0000
16:70350555:AGAT:A	acceptor_gain	1.0000
16:70350556:G:GA	acceptor_gain	1.0000
16:70350556:GA:G	acceptor_gain	1.0000
16:70350556:GAT:G	acceptor_gain	1.0000
16:70350556:GATG:G	acceptor_gain	1.0000
16:70350556:GATGA:G	acceptor_gain	1.0000
16:70355480:TGTA:T	acceptor_loss	1.0000
16:70355481:GTAG:G	acceptor_loss	1.0000
16:70355482:TA:T	acceptor_loss	1.0000
16:70355482:TAGGT:T	acceptor_loss	1.0000
16:70355483:AGG:A	acceptor_loss	1.0000
16:70355484:G:GT	acceptor_loss	1.0000
16:70356244:GGCT:G	donor_gain	1.0000
16:70356245:GCT:G	donor_gain	1.0000
16:70356245:GCTG:G	donor_gain	1.0000
16:70356246:CTG:C	donor_loss	1.0000
16:70356247:TGT:T	donor_loss	1.0000
16:70356247:TGTG:T	donor_loss	1.0000
16:70356248:G:A	donor_loss	1.0000
16:70356248:G:GG	donor_gain	1.0000

AlphaMissense

3173 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:70356231:T:C	F93L	1.000
16:70356232:T:C	F93S	1.000
16:70356232:T:G	F93C	1.000
16:70356233:T:A	F93L	1.000
16:70356233:T:G	F93L	1.000
16:70356241:T:C	L96P	1.000
16:70361455:T:C	F111L	1.000
16:70361457:C:A	F111L	1.000
16:70361457:C:G	F111L	1.000
16:70361465:C:A	P114H	1.000
16:70361474:T:A	I117K	1.000
16:70361474:T:G	I117R	1.000
16:70361478:A:C	Q118H	1.000
16:70361478:A:T	Q118H	1.000
16:70361485:G:C	A121P	1.000
16:70364554:T:C	L133P	1.000
16:70364560:C:A	A135D	1.000
16:70364564:G:C	Q136H	1.000
16:70364564:G:T	Q136H	1.000
16:70364565:T:C	S137P	1.000
16:70364574:G:C	G140R	1.000
16:70364574:G:T	G140C	1.000
16:70364575:G:A	G140D	1.000
16:70364575:G:T	G140V	1.000
16:70364580:G:C	G142R	1.000
16:70364580:G:T	G142C	1.000
16:70364581:G:A	G142D	1.000
16:70364581:G:T	G142V	1.000
16:70364583:A:C	K143Q	1.000
16:70364584:A:T	K143I	1.000

dbSNP variants (sampled 300 via entrez): RS1000039979 (16:70373493 A>G), RS1000048210 (16:70354313 AT>A), RS1000118741 (16:70368009 C>T), RS1000209904 (16:70366423 C>A,T), RS1000279577 (16:70349424 G>A), RS1000324493 (16:70362871 G>A), RS1000527687 (16:70350649 G>T), RS1000540952 (16:70350848 A>G,T), RS1000600015 (16:70360239 C>G,T), RS1000617839 (16:70345940 G>A,C), RS1000834533 (16:70355980 C>G,T), RS1000967523 (16:70372178 T>A), RS1001142003 (16:70345293 G>A), RS1001247989 (16:70373711 T>C,G), RS1001250076 (16:70350849 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST006077_3	Branched-chain amino acid levels (Isoleucine)	2.000000e-08
GCST006078_1	Branched-chain amino acid levels (Valine)	3.000000e-06
GCST010703_100	Brain morphology (MOSTest)	2.000000e-40
GCST010725_47	Malaria	6.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005134	amino acid measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation, increases expression, affects expression	3
bisphenol A	increases methylation, decreases expression, decreases methylation, affects cotreatment	2
pyrogallol 1,3-dimethyl ether	decreases expression, affects cotreatment, affects localization	1
decabromobiphenyl ether	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Atrazine	decreases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	affects expression	1
Furaldehyde	affects cotreatment, affects localization, increases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Manganese	decreases expression, increases abundance	1
Piroxicam	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Smoke	decreases expression	1
Sodium Chloride	affects localization, increases expression, decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.