DDX27

Summary

DDX27 (DEAD-box helicase 27, HGNC:15837) is a protein-coding gene on chromosome 20q13.13, encoding Probable ATP-dependent RNA helicase DDX27 (Q96GQ7). Probable ATP-dependent RNA helicase. It is a common-essential gene (DepMap: required in 97.4% of cancer cell lines).

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3’ end formation of 47S rRNA.

Source: NCBI Gene 55661 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 123 total
• Cancer dependency (DepMap): dependent in 97.4% of screened cell lines (common-essential)
• MANE Select transcript: NM_017895

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15837
Approved symbol	DDX27
Name	DEAD-box helicase 27
Location	20q13.13
Locus type	gene with protein product
Status	Approved
Aliases	dJ686N3.1, DRS1
Ensembl gene	ENSG00000124228
Ensembl biotype	protein_coding
OMIM	616621
Entrez	55661

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 16 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000462328, ENST00000471144, ENST00000484427, ENST00000493252, ENST00000618172, ENST00000870582, ENST00000870583, ENST00000870584, ENST00000939254, ENST00000939255, ENST00000939256, ENST00000939257, ENST00000939258, ENST00000939259, ENST00000939260, ENST00000939261, ENST00000958004, ENST00000958005, ENST00000958006

RefSeq mRNA: 2 — MANE Select: NM_017895 NM_001348187, NM_017895

CCDS: CCDS13416

Canonical transcript exons

ENST00000618172 — 21 exons

Exon	Start	End
ENSE00001150075	49236150	49236231
ENSE00001243341	49233568	49233709
ENSE00001243430	49234935	49235088
ENSE00003460352	49225113	49225199
ENSE00003465938	49226430	49226535
ENSE00003501665	49236333	49236510
ENSE00003522643	49230199	49230349
ENSE00003543674	49242594	49242681
ENSE00003545870	49241893	49241987
ENSE00003565091	49221452	49221598
ENSE00003571321	49228715	49228888
ENSE00003583637	49243629	49243703
ENSE00003583911	49239236	49239338
ENSE00003615018	49233306	49233405
ENSE00003626974	49223268	49223433
ENSE00003646085	49222957	49223016
ENSE00003654088	49242083	49242206
ENSE00003670399	49238949	49239055
ENSE00003689997	49224945	49224991
ENSE00003714970	49219416	49219541
ENSE00003733445	49243816	49244073

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 98.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 52.6104 / max 420.2623, expressed in 1824 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185155	44.7750	1823
185154	6.5480	1721
185156	1.2874	437

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	98.67	gold quality
pancreatic ductal cell	CL:0002079	97.47	gold quality
cervix squamous epithelium	UBERON:0006922	96.01	gold quality
endothelial cell	CL:0000115	95.84	gold quality
tongue squamous epithelium	UBERON:0006919	95.56	gold quality
sural nerve	UBERON:0015488	94.76	gold quality
hair follicle	UBERON:0002073	94.65	gold quality
ileal mucosa	UBERON:0000331	93.48	gold quality
left ovary	UBERON:0002119	93.00	gold quality
right ovary	UBERON:0002118	92.98	gold quality
pylorus	UBERON:0001166	92.96	gold quality
sperm	CL:0000019	92.91	gold quality
pericardium	UBERON:0002407	92.76	gold quality
cardia of stomach	UBERON:0001162	92.72	gold quality
squamous epithelium	UBERON:0006914	92.66	gold quality
male germ cell	CL:0000015	92.58	gold quality
epithelium of nasopharynx	UBERON:0001951	92.37	gold quality
granulocyte	CL:0000094	92.10	gold quality
tendon	UBERON:0000043	92.07	gold quality
lymph node	UBERON:0000029	91.94	gold quality
gingival epithelium	UBERON:0001949	91.94	gold quality
medial globus pallidus	UBERON:0002477	91.93	gold quality
ovary	UBERON:0000992	91.82	gold quality
vena cava	UBERON:0004087	91.71	gold quality
superior surface of tongue	UBERON:0007371	91.71	gold quality
left uterine tube	UBERON:0001303	91.54	gold quality
pharyngeal mucosa	UBERON:0000355	91.49	gold quality
esophagus squamous epithelium	UBERON:0006920	91.49	gold quality
cervix epithelium	UBERON:0004801	91.47	gold quality
parotid gland	UBERON:0001831	91.45	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-6911	no	202.59
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 97.4% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 6)

• Levels of DDX27 mRNA and protein were increased in early-stage gastric tumors, and may be a potential diagnostic and prognostic marker for Gastric cancer. (PMID:25742747)
• The DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3’ end formation of 47S rRNA independently of the PeBoW-complex. (PMID:25825154)
• Data found that DDX27 expression is significantly up-regulated in colorectal cancer (CRC) at mRNA and protein levels. DDX27 mRNA overexpression was positively correlated with DNA copy number gain and associated with poor prognosis in CRC patients. Further evidences prove that DDX27 plays a pivotal oncogenic role in CRC. (PMID:29535419)
• DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer. (PMID:34362383)
• DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling. (PMID:34855554)
• DDX27 regulates oral squamous cell carcinoma development through targeting CSE1L. (PMID:38301874)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ddx27	ENSDARG00000091831
mus_musculus	Ddx27	ENSMUSG00000017999
rattus_norvegicus	Ddx27	ENSRNOG00000008081
drosophila_melanogaster	Rs1	FBGN0021995
caenorhabditis_elegans	ddx-27	WBGENE00022148

Paralogs (38): DDX20 (ENSG00000064703), DDX3Y (ENSG00000067048), DDX1 (ENSG00000079785), DDX43 (ENSG00000080007), DDX18 (ENSG00000088205), DDX24 (ENSG00000089737), DDX17 (ENSG00000100201), DDX49 (ENSG00000105671), DDX50 (ENSG00000107625), DDX5 (ENSG00000108654), DDX25 (ENSG00000109832), DDX6 (ENSG00000110367), DDX55 (ENSG00000111364), DDX59 (ENSG00000118197), DDX54 (ENSG00000123064), DDX39A (ENSG00000123136), DDX31 (ENSG00000125485), DDX56 (ENSG00000136271), EIF4A3 (ENSG00000141543), DDX46 (ENSG00000145833), DDX4 (ENSG00000152670), EIF4A2 (ENSG00000156976), DDX19B (ENSG00000157349), EIF4A1 (ENSG00000161960), DDX21 (ENSG00000165732), DDX19A (ENSG00000168872), TDRD12 (ENSG00000173809), DDX23 (ENSG00000174243), DDX10 (ENSG00000178105), DDX28 (ENSG00000182810), DDX41 (ENSG00000183258), DDX53 (ENSG00000184735), DDX51 (ENSG00000185163), DDX42 (ENSG00000198231), DDX39B (ENSG00000198563), DDX47 (ENSG00000213782), DDX3X (ENSG00000215301), DDX52 (ENSG00000278053)

Protein

Protein identifiers

Probable ATP-dependent RNA helicase DDX27 — Q96GQ7 (reviewed: Q96GQ7)

Alternative names: DEAD box protein 27

All UniProt accessions (4): A0A087WYH5, A0A087X059, B7Z6D5, Q96GQ7

UniProt curated annotations — full annotation on UniProt →

Function. Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA.

Subunit / interactions. Associates with PeBoW complex, composed of BOP1, PES1 and WDR12. Interacts directly with BOP1 and PES1.

Subcellular location. Nucleus. Nucleolus. Chromosome.

Domain organisation. The C-terminal domain regulates nucleolar localization.

Similarity. Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.

RefSeq proteins (2): NP_001335116, NP_060365* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000629	RNA-helicase_DEAD-box_CS	Conserved_site
IPR001650	Helicase_C-like	Domain
IPR011545	DEAD/DEAH_box_helicase_dom	Domain
IPR014001	Helicase_ATP-bd	Domain
IPR014014	RNA_helicase_DEAD_Q_motif	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR050079	DEAD_box_RNA_helicase	Family

Pfam: PF00270, PF00271

Catalyzed reactions (Rhea), 1 shown:

• ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)

UniProt features (27 total): compositionally biased region 5, modified residue 5, sequence conflict 4, short sequence motif 4, region of interest 3, domain 2, chain 1, binding site 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96GQ7-F1	72.06	0.24

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 231–238

Post-translational modifications (5): 23, 25, 48, 135, 146

Mutagenesis-validated functional residues (1):

Position	Phenotype
55–57	no interaction with pebow complex.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 112 (showing top): GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP, WANG_LMO4_TARGETS_DN, BLALOCK_ALZHEIMERS_DISEASE_UP, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, GARY_CD5_TARGETS_DN, ACEVEDO_LIVER_CANCER_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GRADE_COLON_AND_RECTAL_CANCER_UP, GOCC_NUCLEOLUS, GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES, LIU_COMMON_CANCER_GENES, GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP

GO Biological Process (1): rRNA processing (GO:0006364)

GO Molecular Function (8): RNA binding (GO:0003723), RNA helicase activity (GO:0003724), ATP binding (GO:0005524), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), nucleic acid binding (GO:0003676), helicase activity (GO:0004386), hydrolase activity (GO:0016787)

GO Cellular Component (2): chromosome (GO:0005694), nucleolus (GO:0005730)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ATP-dependent activity	2
intracellular membraneless organelle	2
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
nucleic acid binding	1
helicase activity	1
ATP-dependent activity, acting on RNA	1
catalytic activity, acting on RNA	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
nucleic acid conformation isomerase activity	1
catalytic activity, acting on a nucleic acid	1
catalytic activity	1
nuclear lumen	1

Protein interactions and networks

STRING

3516 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DDX27	WDR12	Q9GZL7	626
DDX27	BOP1	Q14137	570
DDX27	DHX15	O43143	500
DDX27	RRS1	Q15050	475
DDX27	PUM3	Q15397	475
DDX27	LYG1	Q8N1E2	474
DDX27	ZNF593	O00488	472
DDX27	CIMIP1	Q9H1P6	449
DDX27	ZNF446	Q9NWS9	449
DDX27	RRP9	O43818	447
DDX27	TM9SF4	Q92544	447
DDX27	TEX10	Q9NXF1	442
DDX27	DHX33	Q9H6R0	441
DDX27	DHX38	Q92620	425
DDX27	DHX37	Q8IY37	424

IntAct

280 interactions, top by confidence:

A	B	Type	Score
WDR12	PES1	psi-mi:“MI:0914”(association)	0.850
XPC	CETN3	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
NCBP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
NPM1	NVL	psi-mi:“MI:0914”(association)	0.610
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
PES1	AP3B1	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
ZNF71	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ZC3HAV1	KHNYN	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530

BioGRID (406): DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DDX27 (Affinity Capture-MS), DCAF13 (Co-fractionation)

ESM2 similar proteins: A1A4H6, A1C7F7, A1CHL3, A1CNV8, A1D1R8, A1DHV3, A2QAX7, A3LSN3, A4QYM6, A5D7C1, A5DKW3, A5DLR3, A5E3K3, A7A0P8, A7TJM9, P0C2N8, P0CQ92, P0CQ93, P26802, P32892, P93008, Q07886, Q09903, Q0INC5, Q0UMB9, Q0UWC8, Q0V1Z7, Q1E2B2, Q2HEB0, Q2UFL0, Q2UQI6, Q4I830, Q4WRV2, Q4X0C2, Q5RC67, Q6C7X8, Q6CEB8, Q6CJV1, Q6FNA2, Q6FW42

Diamond homologs: A0R8U6, A1A4H6, A1CNV8, A1CR32, A1D1R8, A1D405, A2QAX7, A2RB17, A2XKG2, A3LS22, A3LSN3, A4QYM6, A4RGD1, A5DAC8, A5DKW3, A5DQF1, A5DY34, A5E2Z9, A6QRQ7, A6RUH2, A6RW56, A6ZSX1, A7A0P8, A7EML8, A7F4L5, A7TJM9, A7TS37, B9XXL6, O25029, P0C2N7, P0C2N8, P0CQ92, P0CQ93, P0CR00, P0CR01, P25888, P32892, P34580, P38712, P96614

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 222 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	22	20.2×	3e-21
Viral mRNA Translation	22	20.2×	3e-21
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	22	20.0×	4e-21
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	23	19.6×	2e-21
Selenocysteine synthesis	22	19.2×	8e-21
Eukaryotic Translation Termination	22	19.2×	8e-21
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	22	18.8×	1e-20
Formation of a pool of free 40S subunits	22	17.9×	4e-20

GO biological processes:

GO term	Partners	Fold	FDR
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	5	24.0×	2e-04
cytoplasmic translation	22	20.9×	3e-20
ribosomal large subunit biogenesis	8	18.2×	2e-06
ribosomal small subunit biogenesis	13	15.2×	8e-10
peptidyl-tyrosine phosphorylation	7	15.1×	6e-05
negative regulation of viral genome replication	7	13.4×	1e-04
rRNA processing	18	13.1×	9e-13
vascular endothelial growth factor receptor signaling pathway	5	12.3×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

123 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	83
Likely benign	5
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2868 predictions. Top by Δscore:

Variant	Effect	Δscore
20:49219533:G:GT	donor_gain	1.0000
20:49219538:GGAG:G	donor_gain	1.0000
20:49219539:G:GT	donor_gain	1.0000
20:49219539:GAG:G	donor_gain	1.0000
20:49219542:G:GG	donor_gain	1.0000
20:49221448:CCA:C	acceptor_loss	1.0000
20:49221449:CA:C	acceptor_loss	1.0000
20:49221450:A:AC	acceptor_loss	1.0000
20:49221450:A:AG	acceptor_gain	1.0000
20:49221450:AG:A	acceptor_gain	1.0000
20:49221450:AGG:A	acceptor_gain	1.0000
20:49221450:AGGG:A	acceptor_gain	1.0000
20:49221451:G:GC	acceptor_gain	1.0000
20:49221451:G:T	acceptor_loss	1.0000
20:49221451:GG:G	acceptor_gain	1.0000
20:49221451:GGG:G	acceptor_gain	1.0000
20:49221451:GGGG:G	acceptor_gain	1.0000
20:49221594:AGAAG:A	donor_loss	1.0000
20:49221595:GAAG:G	donor_gain	1.0000
20:49221596:AAGG:A	donor_loss	1.0000
20:49221597:AGGT:A	donor_loss	1.0000
20:49221598:GGT:G	donor_loss	1.0000
20:49221599:G:GA	donor_loss	1.0000
20:49221600:T:A	donor_loss	1.0000
20:49222949:A:AG	acceptor_gain	1.0000
20:49222954:CAG:C	acceptor_gain	1.0000
20:49222954:CAGA:C	acceptor_loss	1.0000
20:49222955:A:AG	acceptor_gain	1.0000
20:49222955:AGA:A	acceptor_gain	1.0000
20:49222955:AGAG:A	acceptor_gain	1.0000

AlphaMissense

5037 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:49226515:C:A	A260D	1.000
20:49226529:G:T	G265W	1.000
20:49226530:G:A	G265E	1.000
20:49228715:G:A	G267D	1.000
20:49228727:C:A	A271D	1.000
20:49228793:T:C	L293P	1.000
20:49228805:C:A	P297H	1.000
20:49228805:C:G	P297R	1.000
20:49228813:G:A	E300K	1.000
20:49228817:T:C	L301P	1.000
20:49228819:G:C	G302R	1.000
20:49230199:G:A	G325D	1.000
20:49230259:C:A	A345D	1.000
20:49230265:C:A	P347Q	1.000
20:49230267:G:C	G348R	1.000
20:49230268:G:A	G348D	1.000
20:49230271:G:C	R349P	1.000
20:49230274:T:C	L350P	1.000
20:49230286:T:C	L354P	1.000
20:49230328:T:C	L368P	1.000
20:49230334:T:C	L370P	1.000
20:49230337:A:C	D371A	1.000
20:49230339:G:A	E372K	1.000
20:49230339:G:C	E372Q	1.000
20:49230340:A:C	E372A	1.000
20:49230340:A:G	E372G	1.000
20:49230340:A:T	E372V	1.000
20:49230341:G:C	E372D	1.000
20:49230341:G:T	E372D	1.000
20:49230342:G:C	A373P	1.000

dbSNP variants (sampled 300 via entrez): RS1000097641 (20:49229324 C>T), RS1000213839 (20:49242248 C>T), RS1000230241 (20:49238301 G>A,C), RS1000376657 (20:49244196 G>A), RS1000406975 (20:49229183 A>C,G), RS1000569641 (20:49227131 G>A,C), RS1000793384 (20:49219101 T>C), RS1000899189 (20:49232590 T>C), RS1001504393 (20:49236619 C>T), RS1001525495 (20:49227066 T>A,C,G), RS1001555299 (20:49236254 G>C), RS1001572179 (20:49229760 C>T), RS1001638553 (20:49221845 G>A), RS1001659041 (20:49233824 C>A,T), RS1001683008 (20:49227598 C>T)

Disease associations

OMIM: gene MIM:616621 | disease phenotypes: MIM:616056

GenCC curated gene-disease

Mondo (1): developmental and epileptic encephalopathy, 26 (MONDO:0014477)

Orphanet (1): Non-specific early-onset epileptic encephalopathy (Orphanet:442835)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005316_251	Intelligence (MTAG)	3.000000e-13
GCST006923_15	Loneliness	3.000000e-08
GCST006924_7	Loneliness (MTAG)	3.000000e-09
GCST007044_24	Extremely high intelligence	7.000000e-10
GCST008839_11	Height	2.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression	2
Estradiol	affects cotreatment, increases expression	2
Cyclosporine	increases expression	2
deoxynivalenol	increases expression	1
afimoxifene	decreases expression	1
nivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Arsenic	affects methylation	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Bucladesine	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Haloperidol	increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	affects cotreatment, increases expression	1
Aflatoxin B1	affects cotreatment, decreases expression	1
Medroxyprogesterone Acetate	affects cotreatment, increases expression	1
beta-Naphthoflavone	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.