DDX51

Summary

DDX51 (DEAD-box helicase 51, HGNC:20082) is a protein-coding gene on chromosome 12q24.33, encoding ATP-dependent RNA helicase DDX51 (Q8N8A6). ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. It is a common-essential gene (DepMap: required in 96.6% of cancer cell lines).

Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane.

Source: NCBI Gene 317781 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 186 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 96.6% of screened cell lines (common-essential)
• MANE Select transcript: NM_175066

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20082
Approved symbol	DDX51
Name	DEAD-box helicase 51
Location	12q24.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000185163
Ensembl biotype	protein_coding
Entrez	317781

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 8 protein_coding, 5 retained_intron

ENST00000329073, ENST00000397333, ENST00000462829, ENST00000541489, ENST00000545991, ENST00000546058, ENST00000864667, ENST00000919064, ENST00000919065, ENST00000919066, ENST00000960080, ENST00000960081, ENST00000960082

RefSeq mRNA: 1 — MANE Select: NM_175066 NM_175066

CCDS: CCDS41865

Canonical transcript exons

ENST00000397333 — 15 exons

Exon	Start	End
ENSE00001301508	132143993	132144319
ENSE00001302733	132142728	132142878
ENSE00001324623	132143695	132143909
ENSE00001528235	132136594	132139298
ENSE00003473661	132139635	132139769
ENSE00003473703	132142119	132142190
ENSE00003480365	132140098	132140199
ENSE00003528149	132139861	132139924
ENSE00003534230	132142277	132142422
ENSE00003536349	132140620	132140735
ENSE00003577993	132140831	132141020
ENSE00003620265	132141275	132141420
ENSE00003627912	132140423	132140539
ENSE00003656622	132141850	132141956
ENSE00003677605	132141498	132141606

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 90.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.0562 / max 229.1759, expressed in 1779 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134191	13.0562	1779

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	90.22	gold quality
right frontal lobe	UBERON:0002810	90.02	gold quality
cerebellar hemisphere	UBERON:0002245	89.76	gold quality
cerebellar cortex	UBERON:0002129	89.66	gold quality
cerebellum	UBERON:0002037	89.65	gold quality
pituitary gland	UBERON:0000007	89.55	gold quality
left ovary	UBERON:0002119	89.37	gold quality
right uterine tube	UBERON:0001302	89.08	gold quality
apex of heart	UBERON:0002098	88.91	gold quality
right ovary	UBERON:0002118	88.82	gold quality
body of pancreas	UBERON:0001150	88.69	gold quality
ovary	UBERON:0000992	88.46	gold quality
adenohypophysis	UBERON:0002196	88.30	gold quality
granulocyte	CL:0000094	88.29	gold quality
left uterine tube	UBERON:0001303	88.04	gold quality
body of uterus	UBERON:0009853	87.44	gold quality
spleen	UBERON:0002106	87.18	gold quality
frontal cortex	UBERON:0001870	86.81	gold quality
right testis	UBERON:0004534	86.72	gold quality
right lobe of thyroid gland	UBERON:0001119	86.67	gold quality
tibial nerve	UBERON:0001323	86.65	gold quality
ectocervix	UBERON:0012249	86.58	gold quality
nucleus accumbens	UBERON:0001882	86.57	gold quality
mucosa of transverse colon	UBERON:0004991	86.56	gold quality
left testis	UBERON:0004533	86.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.46	gold quality
brain	UBERON:0000955	86.44	gold quality
anterior cingulate cortex	UBERON:0009835	86.40	gold quality
endocervix	UBERON:0000458	86.36	gold quality
body of stomach	UBERON:0001161	86.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.44

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

49 targeting DDX51, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-4743-3P	99.62	68.12	2095
HSA-MIR-6832-5P	99.58	64.82	1132
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-12113	99.32	67.54	1072
HSA-MIR-3064-5P	99.26	66.13	1497
HSA-MIR-3085-3P	99.26	66.16	1490
HSA-MIR-6504-5P	99.26	65.95	1487
HSA-MIR-7974	99.24	65.48	1137
HSA-MIR-6504-3P	99.17	69.31	2891
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-181A-2-3P	98.91	67.60	1168
HSA-MIR-4716-5P	98.82	68.57	1168
HSA-MIR-3149	98.77	67.13	1639
HSA-MIR-3908	98.75	67.31	1160
HSA-MIR-4752	98.71	68.04	833

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 96.6% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• these data suggest that DDX51 aids cell cancer proliferation by regulating multiple signaling pathways (PMID:27198888)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ddx51	ENSDARG00000025854
mus_musculus	Ddx51	ENSMUSG00000029504
rattus_norvegicus	Ddx51	ENSRNOG00000037480
drosophila_melanogaster	Dbp73D	FBGN0004556
caenorhabditis_elegans		WBGENE00022792

Paralogs (38): DDX20 (ENSG00000064703), DDX3Y (ENSG00000067048), DDX1 (ENSG00000079785), DDX43 (ENSG00000080007), DDX18 (ENSG00000088205), DDX24 (ENSG00000089737), DDX17 (ENSG00000100201), DDX49 (ENSG00000105671), DDX50 (ENSG00000107625), DDX5 (ENSG00000108654), DDX25 (ENSG00000109832), DDX6 (ENSG00000110367), DDX55 (ENSG00000111364), DDX59 (ENSG00000118197), DDX54 (ENSG00000123064), DDX39A (ENSG00000123136), DDX27 (ENSG00000124228), DDX31 (ENSG00000125485), DDX56 (ENSG00000136271), EIF4A3 (ENSG00000141543), DDX46 (ENSG00000145833), DDX4 (ENSG00000152670), EIF4A2 (ENSG00000156976), DDX19B (ENSG00000157349), EIF4A1 (ENSG00000161960), DDX21 (ENSG00000165732), DDX19A (ENSG00000168872), TDRD12 (ENSG00000173809), DDX23 (ENSG00000174243), DDX10 (ENSG00000178105), DDX28 (ENSG00000182810), DDX41 (ENSG00000183258), DDX53 (ENSG00000184735), DDX42 (ENSG00000198231), DDX39B (ENSG00000198563), DDX47 (ENSG00000213782), DDX3X (ENSG00000215301), DDX52 (ENSG00000278053)

Protein

Protein identifiers

ATP-dependent RNA helicase DDX51 — Q8N8A6 (reviewed: Q8N8A6)

Alternative names: DEAD box protein 51

All UniProt accessions (1): Q8N8A6

UniProt curated annotations — full annotation on UniProt →

Function. ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

Subcellular location. Nucleus. Nucleolus.

Domain organisation. The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Similarity. Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.

RefSeq proteins (1): NP_778236* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000629	RNA-helicase_DEAD-box_CS	Conserved_site
IPR001650	Helicase_C-like	Domain
IPR011545	DEAD/DEAH_box_helicase_dom	Domain
IPR014001	Helicase_ATP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00270, PF00271

Catalyzed reactions (Rhea), 1 shown:

• ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)

UniProt features (28 total): sequence variant 8, compositionally biased region 5, sequence conflict 4, modified residue 3, domain 2, short sequence motif 2, initiator methionine 1, chain 1, binding site 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N8A6-F1	74.64	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 256–263

Post-translational modifications (3): 2, 83, 103

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 158 (showing top): GOBP_RIBOSOME_BIOGENESIS, SHEPARD_CRASH_AND_BURN_MUTANT_UP, CREBP1_Q2, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, CREB_Q4, E4F1_Q6, ATF3_Q6, CREB_Q2_01, ATF4_Q2, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, BURTON_ADIPOGENESIS_4, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, ATF_01, CREBP1CJUN_01, CREB_01

GO Biological Process (2): rRNA processing (GO:0006364), ribosome biogenesis (GO:0042254)

GO Molecular Function (8): RNA binding (GO:0003723), RNA helicase activity (GO:0003724), ATP binding (GO:0005524), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), nucleic acid binding (GO:0003676), helicase activity (GO:0004386), hydrolase activity (GO:0016787)

GO Cellular Component (3): nucleus (GO:0005634), nucleolus (GO:0005730), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ATP-dependent activity	2
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
ribonucleoprotein complex biogenesis	1
nucleic acid binding	1
helicase activity	1
ATP-dependent activity, acting on RNA	1
catalytic activity, acting on RNA	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
nucleic acid conformation isomerase activity	1
catalytic activity, acting on a nucleic acid	1
catalytic activity	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular membraneless organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2843 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DDX51	CFAP45	Q9UL16	600
DDX51	NOL10	Q9BSC4	563
DDX51	NOL9	Q5SY16	541
DDX51	RRP9	O43818	525
DDX51	PDCD11	Q14690	522
DDX51	RBM34	P42696	517
DDX51	URB1	O60287	505
DDX51	PPAN	Q9NQ55	484
DDX51	A0A0B4J1V8	A0A0B4J1V8	483
DDX51	WRAP73	Q9P2S5	471
DDX51	NOP58	Q9Y2X3	468
DDX51	WDR36	Q8NI36	466
DDX51	GTPBP4	Q9BZE4	462
DDX51	RRP8	O43159	458
DDX51	NOP56	O00567	448

IntAct

127 interactions, top by confidence:

A	B	Type	Score
NEUROG3	GXYLT2	psi-mi:“MI:0914”(association)	0.640
MECP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
ILF3	ADAR	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
CASQ2	PES1	psi-mi:“MI:0914”(association)	0.530
CCDC59	GAPDHS	psi-mi:“MI:0914”(association)	0.530
SRPK2	RRP9	psi-mi:“MI:0914”(association)	0.530
GTF3C2	C1QBP	psi-mi:“MI:0914”(association)	0.530
RRP8	MAGEB2	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530

BioGRID (146): DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Co-fractionation), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS), DDX51 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8Y7D0, A1L020, A2ARS0, A6NDN8, G1T8A2, O70418, O75426, P29473, P29597, P49897, P49898, P52824, P55073, P62861, P62862, P70313, P79209, Q08097, Q08DF2, Q148R9, Q1LZC5, Q28969, Q39491, Q4R327, Q566C8, Q5SPX3, Q62600, Q6DN07, Q6H5L4, Q6N063, Q6NXT1, Q6QN11, Q6ZS82, Q758T2, Q7L9B9, Q86SG2, Q8C2K5, Q8MJG0, Q8N8A6, Q8TD08

Diamond homologs: A1CIQ5, A1CKJ0, A1CR32, A1CW14, A1D405, A1D6X9, A2QA23, A2RB17, A2XKG2, A3LNR6, A3LS22, A3LSJ2, A3LSN3, A4QYM6, A4RGD1, A5D7C1, A5DID7, A5DK47, A5DLE0, A5DQF1, A5DS77, A5DY34, A5E726, A6QRQ7, A6RUH2, A6RW56, A6ZSB3, A6ZSX1, A7EML8, A7F4L5, A7TFZ9, A7TS37, O22907, P0CR00, P0CR01, P25888, P26802, P34580, P38712, P53734

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 142 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	13	16.7×	9e-11
Viral mRNA Translation	13	16.7×	9e-11
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	13	16.5×	9e-11
Selenocysteine synthesis	13	15.8×	1e-10
Eukaryotic Translation Termination	13	15.8×	1e-10
Response of EIF2AK4 (GCN2) to amino acid deficiency	14	15.7×	6e-11
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	13	15.5×	1e-10
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	13	15.5×	1e-10

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal large subunit biogenesis	8	27.3×	1e-07
cytoplasmic translation	14	19.9×	8e-12
rRNA processing	13	14.2×	4e-09
positive regulation of miRNA transcription	6	13.4×	7e-04
ribosomal small subunit biogenesis	7	12.3×	3e-04
RNA processing	7	11.8×	4e-04
translation	14	11.1×	1e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

186 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	152
Likely benign	16
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3244436	NC_000012.11:g.(?132414268)(133263901_?)del	Pathogenic

SpliceAI

2456 predictions. Top by Δscore:

Variant	Effect	Δscore
12:132139630:CTTA:C	donor_loss	1.0000
12:132139631:TTA:T	donor_loss	1.0000
12:132139632:TACCT:T	donor_loss	1.0000
12:132139633:A:AG	donor_loss	1.0000
12:132140092:GCTCA:G	donor_loss	1.0000
12:132140093:CTCAC:C	donor_loss	1.0000
12:132140094:TCACC:T	donor_loss	1.0000
12:132140095:CA:C	donor_loss	1.0000
12:132140096:A:AC	donor_gain	1.0000
12:132140096:AC:A	donor_gain	1.0000
12:132140097:C:CT	donor_gain	1.0000
12:132140097:CC:C	donor_gain	1.0000
12:132140418:CTCA:C	donor_loss	1.0000
12:132140419:TCACA:T	donor_loss	1.0000
12:132140420:CA:C	donor_loss	1.0000
12:132140421:A:AC	donor_gain	1.0000
12:132140421:AC:A	donor_loss	1.0000
12:132140421:ACAG:A	donor_gain	1.0000
12:132140422:C:CC	donor_gain	1.0000
12:132140422:CA:C	donor_gain	1.0000
12:132140422:CAG:C	donor_gain	1.0000
12:132140422:CAGC:C	donor_gain	1.0000
12:132140433:T:TA	donor_gain	1.0000
12:132140434:C:A	donor_gain	1.0000
12:132140535:AGAGC:A	acceptor_gain	1.0000
12:132140536:GAGC:G	acceptor_gain	1.0000
12:132140538:GC:G	acceptor_gain	1.0000
12:132140538:GCCTA:G	acceptor_loss	1.0000
12:132140539:CC:C	acceptor_gain	1.0000
12:132140540:C:CC	acceptor_gain	1.0000

AlphaMissense

4262 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:132140098:C:G	R592P	0.998
12:132140190:G:C	S561R	0.998
12:132140190:G:T	S561R	0.998
12:132140192:T:G	S561R	0.998
12:132140102:G:C	H591D	0.997
12:132140646:G:C	F510L	0.997
12:132140646:G:T	F510L	0.997
12:132140648:A:G	F510L	0.997
12:132141410:T:A	E372V	0.997
12:132141553:A:G	L350P	0.997
12:132139915:C:A	R595S	0.996
12:132139915:C:G	R595S	0.996
12:132141401:C:G	R375P	0.996
12:132141569:C:G	A345P	0.996
12:132141404:T:A	D374V	0.995
12:132141405:C:G	D374H	0.995
12:132141408:C:G	A373P	0.995
12:132141410:T:G	E372A	0.995
12:132141499:A:G	L368P	0.995
12:132141556:C:G	R349P	0.995
12:132142153:A:G	L285P	0.995
12:132139916:C:G	R595T	0.994
12:132140136:G:C	N579K	0.994
12:132140136:G:T	N579K	0.994
12:132140177:C:G	A566P	0.994
12:132140651:A:G	C509R	0.994
12:132140703:C:A	K491N	0.994
12:132140703:C:G	K491N	0.994
12:132142126:G:T	A294D	0.994
12:132142332:A:T	V254D	0.994

dbSNP variants (sampled 300 via entrez): RS1000269617 (12:132142812 G>A,C,T), RS1000521431 (12:132143414 C>G,T), RS1000575013 (12:132140616 T>C), RS1000819124 (12:132143415 G>A), RS1000922669 (12:132136931 T>A), RS1001138798 (12:132136612 T>C), RS1001199394 (12:132143663 C>A,G,T), RS1001421656 (12:132140003 C>T), RS1001533438 (12:132144202 C>A,T), RS1001689037 (12:132143688 G>A,T), RS1002039657 (12:132143241 A>G), RS1002239931 (12:132144650 G>A,C,T), RS1002371281 (12:132143368 C>T), RS1002520205 (12:132138904 C>G,T), RS1002700673 (12:132141781 C>A,G,T)

Disease associations

OMIM: gene `` | disease phenotypes: MIM:615083

GenCC curated gene-disease

Mondo (1): colorectal cancer, susceptibility to, 12 (MONDO:0014038)

Orphanet (1): Attenuated familial adenomatous polyposis (Orphanet:220460)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST005951_3	Body mass index	6.000000e-09
GCST007059_15	Response to antidepressants (symptom improvement)	5.000000e-06
GCST007060_6	Response to SSRI (symptom remission)	3.000000e-06
GCST008163_561	Height	2.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0005658	response to selective serotonin reuptake inhibitor

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression	2
Tretinoin	decreases expression	2
Valproic Acid	affects expression, increases methylation	2
FR900359	increases phosphorylation	1
tamibarotene	affects expression	1
di-n-butylphosphoric acid	affects expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Arsenic	increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	decreases phosphorylation	1
Cisplatin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	increases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Phenobarbital	affects expression	1
Phthalic Acids	decreases expression	1
Plant Extracts	decreases expression	1
Potassium Dichromate	increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Cyclosporine	increases expression	1
Asbestos, Crocidolite	decreases expression	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.