DELE1

Summary

DELE1 (DAP3 binding cell death enhancer 1, HGNC:28969) is a protein-coding gene on chromosome 5q31.3, encoding DAP3-binding cell death enhancer 1 (Q14154). Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks.

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including HRI-mediated signaling; positive regulation of mitophagy; and response to iron ion starvation. Located in mitochondrial inner membrane. Is active in cytosol and mitochondrial outer membrane.

Source: NCBI Gene 9812 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 116 total
• MANE Select transcript: NM_014773

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28969
Approved symbol	DELE1
Name	DAP3 binding cell death enhancer 1
Location	5q31.3
Locus type	gene with protein product
Status	Approved
Aliases	DELE
Ensembl gene	ENSG00000081791
Ensembl biotype	protein_coding
OMIM	615741
Entrez	9812

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 12 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000194118, ENST00000432126, ENST00000502729, ENST00000506775, ENST00000507481, ENST00000508751, ENST00000509110, ENST00000895929, ENST00000895930, ENST00000895931, ENST00000895932, ENST00000924856, ENST00000959461, ENST00000959462, ENST00000959463

RefSeq mRNA: 2 — MANE Select: NM_014773 NM_001142603, NM_014773

CCDS: CCDS4268

Canonical transcript exons

ENST00000432126 — 12 exons

Exon	Start	End
ENSE00000447191	141928151	141928298
ENSE00000447198	141937198	141937357
ENSE00000766679	141934494	141934586
ENSE00000766683	141929989	141930074
ENSE00000766684	141929582	141929740
ENSE00000766686	141925410	141925527
ENSE00000814316	141924581	141924695
ENSE00001157065	141930178	141930274
ENSE00001747703	141938521	141942047
ENSE00001862276	141923871	141923972
ENSE00003546685	141933259	141933401
ENSE00003641318	141934240	141934398

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 97.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 61.8155 / max 320.8463, expressed in 1826 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
59054	31.2524	1817
59055	28.7983	1818
59056	1.7648	1095

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	97.70	gold quality
apex of heart	UBERON:0002098	97.38	gold quality
cerebellar hemisphere	UBERON:0002245	97.19	gold quality
right atrium auricular region	UBERON:0006631	96.88	gold quality
cerebellar cortex	UBERON:0002129	96.87	gold quality
body of uterus	UBERON:0009853	96.62	gold quality
right adrenal gland cortex	UBERON:0035827	96.62	gold quality
right adrenal gland	UBERON:0001233	96.53	gold quality
rectum	UBERON:0001052	96.46	gold quality
left adrenal gland	UBERON:0001234	96.37	gold quality
right lung	UBERON:0002167	96.32	gold quality
left adrenal gland cortex	UBERON:0035825	96.31	gold quality
right lobe of thyroid gland	UBERON:0001119	96.25	gold quality
granulocyte	CL:0000094	96.24	gold quality
endocervix	UBERON:0000458	96.22	gold quality
metanephros cortex	UBERON:0010533	96.15	gold quality
transverse colon	UBERON:0001157	96.14	gold quality
upper lobe of left lung	UBERON:0008952	96.13	gold quality
heart left ventricle	UBERON:0002084	96.07	gold quality
monocyte	CL:0000576	96.03	gold quality
spleen	UBERON:0002106	96.01	gold quality
mononuclear cell	CL:0000842	95.93	gold quality
left ovary	UBERON:0002119	95.91	gold quality
ectocervix	UBERON:0012249	95.89	gold quality
body of stomach	UBERON:0001161	95.88	gold quality
leukocyte	CL:0000738	95.84	gold quality
right ovary	UBERON:0002118	95.83	gold quality
left uterine tube	UBERON:0001303	95.79	gold quality
cardiac ventricle	UBERON:0002082	95.79	gold quality
left lobe of thyroid gland	UBERON:0001120	95.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

111 targeting DELE1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-3913-5P	99.78	67.26	968
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-3129-5P	99.75	70.46	914

Literature-anchored findings (GeneRIF, showing 7)

• identifies a novel DAP3-binding protein termed death ligand signal enhancer (DELE); demonstrates the biological significance of DELE for apoptosis signal mediated by death receptors (PMID:20563667)
• the mitochondrial protease OMA1 and the poorly characterized protein DELE1, together with HRI, constitute the missing pathway that is triggered by mitochondrial stress; these findings could be used to inform future strategies to modulate the cellular response to mitochondrial dysfunction in the context of human disease (PMID:32132706)
• mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway; the OMA1-DELE1-HRI pathway represents a potential therapeutic target that could enable fine-tuning of the integrated stress response for beneficial outcomes in diseases that involve mitochondrial dysfunction (PMID:32132707)
• The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. (PMID:35163244)
• Death associated protein3 (DAP3) and DAP3 binding cell death enhancer1 (DELE1) in human colorectal cancer, and their impacts on clinical outcome and chemoresistance. (PMID:36382667)
• DELE1 is protective for mitochondrial cardiomyopathy. (PMID:36539111)
• DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML. (PMID:38102204)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dele1	ENSDARG00000104789
mus_musculus	Dele1	ENSMUSG00000024442
rattus_norvegicus	Dele1	ENSRNOG00000019276
caenorhabditis_elegans		WBGENE00004759

Paralogs (4): SEL1L (ENSG00000071537), SEL1L3 (ENSG00000091490), SEL1L2 (ENSG00000101251), LRP2BP (ENSG00000109771)

Protein

Protein identifiers

DAP3-binding cell death enhancer 1 — Q14154 (reviewed: Q14154)

Alternative names: DAP3-binding cell death enhancer 1, long form, Death ligand signal enhancer

All UniProt accessions (3): Q14154, D6RBI8, H0YA48

UniProt curated annotations — full annotation on UniProt →

Function. Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy.

Subunit / interactions. Interacts with DAP3. Interacts (via TPR repeats) with EIF2AK1/HRI; activating the protein kinase activity of EIF2AK1/HRI, thereby promoting the integrated stress response (ISR). Homooctamer; oligomerization is required to activate EIF2AK1/HRI. Interacts (via TPR repeats) with EIF2AK1/HRI; activating the protein kinase activity of EIF2AK1/HRI, thereby promoting the integrated stress response (ISR).

Subcellular location. Mitochondrion. Mitochondrion outer membrane. Mitochondrion inner membrane Cytoplasm. Cytosol.

Tissue specificity. Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Post-translational modifications. Unstable protein in absence of stress: imported in the mitochondrial matrix following processing by the mitochondrial-processing peptidase (MPP), where it is degraded by LONP1. Stabilized in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization. Cleaved by OMA1 in response to mitochondrial stress, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1) that accumulates in the cytosol and activates the protein kinase activity of EIF2AK1/HRI. Protein cleavage by OMA1 can take place at different positions, and apparently does not require a specific sequence motif. Ubiquitinated and degraded by the SIFI complex once the mitochondrial stress has been resolved, thereby providing stress response silencing. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.

Domain organisation. The TPR repeats bind to and activate EIF2AK1/HRI.

Similarity. Belongs to the DELE1 family.

RefSeq proteins (2): NP_001136075, NP_055588* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006597	Sel1-like	Repeat
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR052748	ISR_Activator	Family

Pfam: PF08238

UniProt features (29 total): mutagenesis site 8, repeat 7, sequence variant 5, region of interest 2, chain 2, transit peptide 1, propeptide 1, short sequence motif 1, compositionally biased region 1, site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8D9X	ELECTRON MICROSCOPY	3.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14154-F1	61.63	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 142–143 (cleavage; by oma1)

Mutagenesis-validated functional residues (8):

Position	Phenotype
239–251	impaired oligomerization and ability to activate eif2ak1/hri.
239	impaired oligomerization.
242–251	impaired oligomerization and ability to activate eif2ak1/hri.
242	impaired oligomerization.
244	impaired oligomerization and ability to activate eif2ak1/hri.
250–251	impaired oligomerization and ability to activate eif2ak1/hri.
403	impaired oligomerization; when associated with s-431.
431	impaired oligomerization; when associated with s-403.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9840373	Cellular response to mitochondrial stress

MSigDB gene sets: 137 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, RRAGTTGT_UNKNOWN, GOBP_REGULATION_OF_AUTOPHAGY, HOEGERKORP_CD44_TARGETS_TEMPORAL_DN, GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, GOBP_MACROAUTOPHAGY, GOMF_KINASE_ACTIVATOR_ACTIVITY, GOBP_APOPTOTIC_SIGNALING_PATHWAY, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, BROWNE_HCMV_INFECTION_14HR_DN, GOBP_DNA_DAMAGE_RESPONSE

GO Biological Process (10): DNA damage response (GO:0006974), extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625), cellular response to stress (GO:0033554), HRI-mediated signaling (GO:0140468), positive regulation of mitophagy (GO:1901526), response to iron ion starvation (GO:1990641), mitophagy (GO:0000423), translational initiation (GO:0006413), apoptotic process (GO:0006915), protein localization to mitochondrion (GO:0070585)

GO Molecular Function (2): protein serine/threonine kinase activator activity (GO:0043539), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), mitochondrial inner membrane (GO:0005743), cytosol (GO:0005829), cytoplasm (GO:0005737), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Cellular responses to stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
mitochondrial membrane	2
cellular response to stress	1
extrinsic apoptotic signaling pathway	1
response to stress	1
cellular response to stimulus	1
integrated stress response signaling	1
mitophagy	1
positive regulation of macroautophagy	1
regulation of mitophagy	1
positive regulation of autophagy of mitochondrion	1
response to metal ion starvation	1
autophagy of mitochondrion	1
macroautophagy	1
formation of translation initiation ternary complex	1
translation	1
metabolic process	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
protein localization to organelle	1
protein serine/threonine kinase activity	1
protein kinase activator activity	1
binding	1
intracellular membrane-bounded organelle	1
organelle outer membrane	1
organelle inner membrane	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

668 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DELE1	OMA1	Q96E52	758
DELE1	TOR1A	O14656	714
DELE1	DAP3	P51398	662
DELE1	LMNA	P02545	654
DELE1	ENO2	P09104	648
DELE1	UBB	P02248	593
DELE1	CLPB	Q9H078	567
DELE1	ATF5	Q9Y2D1	484
DELE1	RBM27	Q9P2N5	436
DELE1	LONP1	P36776	426
DELE1	THAP1	Q9NVV9	424
DELE1	TOR1B	O14657	424
DELE1	HPCA	P32076	423
DELE1	EIF2AK1	Q9BQI3	399
DELE1	EIF2A	Q9BY44	391

IntAct

55 interactions, top by confidence:

A	B	Type	Score
BRAF	HRAS	psi-mi:“MI:0914”(association)	0.940
DELE1	CRX	psi-mi:“MI:0915”(physical association)	0.560
CRX	DELE1	psi-mi:“MI:0915”(physical association)	0.560
ATP5PB	DELE1	psi-mi:“MI:0915”(physical association)	0.560
DELE1	DNM2	psi-mi:“MI:0915”(physical association)	0.560
DELE1	TOR1A	psi-mi:“MI:0915”(physical association)	0.560
DELE1		psi-mi:“MI:0915”(physical association)	0.560
DELE1	LSAMP	psi-mi:“MI:0915”(physical association)	0.560
NDUFS1	DELE1	psi-mi:“MI:0915”(physical association)	0.560
KLF11	DELE1	psi-mi:“MI:0915”(physical association)	0.560
NUP58	DELE1	psi-mi:“MI:0915”(physical association)	0.560
HTT	DELE1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (12): KIAA0141 (Two-hybrid), KIAA0141 (Two-hybrid), EIF2AK1 (Affinity Capture-MS), EIF2AK1 (Affinity Capture-MS), KIAA0141 (Affinity Capture-MS), KIAA0141 (Affinity Capture-MS), KIAA0141 (Affinity Capture-RNA), EIF2AK1 (Affinity Capture-MS), KIAA0141 (Affinity Capture-MS), KIAA0141 (Affinity Capture-MS), KIAA0141 (PCA), KIAA0141 (PCA)

ESM2 similar proteins: A1L3T7, A2A3L6, A4IFI1, A7E3N7, A8MYJ7, A8VU90, O94761, O94812, O95153, O95382, P97680, Q0P5G1, Q13671, Q14154, Q3UYR4, Q4V896, Q53GL7, Q569K6, Q58CQ5, Q58EX7, Q66H85, Q6DT37, Q6F5E8, Q6ZVH7, Q76MJ5, Q7TNF8, Q7Z3H0, Q80UU1, Q80UW5, Q8BWA8, Q8BXP5, Q8BYG0, Q8CIE4, Q8CJ00, Q8IYJ3, Q8NAG6, Q8TE82, Q91WA6, Q91WE1, Q921Q7

Diamond homologs: P60924, Q14154, Q9DCV6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	85
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1602 predictions. Top by Δscore:

Variant	Effect	Δscore
5:141928148:CAG:C	acceptor_loss	1.0000
5:141928299:G:GG	donor_gain	1.0000
5:141930244:C:G	donor_gain	1.0000
5:141934238:AGGC:A	acceptor_gain	1.0000
5:141934239:GGCG:G	acceptor_gain	1.0000
5:141923969:CGAGG:C	donor_loss	0.9900
5:141923971:AGG:A	donor_loss	0.9900
5:141923972:GGTAA:G	donor_loss	0.9900
5:141923973:G:A	donor_loss	0.9900
5:141923974:T:A	donor_loss	0.9900
5:141928149:A:AG	acceptor_gain	0.9900
5:141928149:AG:A	acceptor_gain	0.9900
5:141928150:G:A	acceptor_gain	0.9900
5:141928150:G:GG	acceptor_gain	0.9900
5:141928150:GGGC:G	acceptor_gain	0.9900
5:141928294:CTCCT:C	donor_gain	0.9900
5:141928295:TCCT:T	donor_gain	0.9900
5:141928296:CCT:C	donor_gain	0.9900
5:141928297:CT:C	donor_gain	0.9900
5:141928298:TGTG:T	donor_loss	0.9900
5:141928299:G:GA	donor_loss	0.9900
5:141928300:TGA:T	donor_loss	0.9900
5:141928301:GAGT:G	donor_loss	0.9900
5:141928302:AGT:A	donor_loss	0.9900
5:141929576:TTCCA:T	acceptor_loss	0.9900
5:141929578:CCAGC:C	acceptor_loss	0.9900
5:141929579:CAGCA:C	acceptor_loss	0.9900
5:141929580:A:AG	acceptor_gain	0.9900
5:141929580:A:AT	acceptor_loss	0.9900
5:141929581:G:GG	acceptor_gain	0.9900

AlphaMissense

3306 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:141933355:G:A	G284D	0.993
5:141937207:A:C	S387R	0.993
5:141937209:C:A	S387R	0.993
5:141937209:C:G	S387R	0.993
5:141937223:G:A	G392E	0.991
5:141937222:G:A	G392R	0.990
5:141937222:G:C	G392R	0.990
5:141934509:G:T	G358W	0.989
5:141934575:G:C	A380P	0.989
5:141934262:C:A	A307D	0.988
5:141934264:G:C	A308P	0.988
5:141933318:G:C	A272P	0.987
5:141933345:T:G	Y281D	0.987
5:141934378:G:C	A346P	0.987
5:141930274:G:A	G252R	0.986
5:141930274:G:C	G252R	0.986
5:141933354:G:C	G284R	0.986
5:141934509:G:A	G358R	0.986
5:141934509:G:C	G358R	0.986
5:141934510:G:A	G358E	0.986
5:141930267:C:A	N249K	0.985
5:141930267:C:G	N249K	0.985
5:141934564:T:C	L376P	0.984
5:141933259:G:A	G252E	0.983
5:141933307:T:C	F268S	0.983
5:141937282:T:G	Y412D	0.983
5:141933315:G:C	A271P	0.982
5:141934286:C:A	A315D	0.982
5:141934295:G:C	R318P	0.982
5:141937220:T:C	L391P	0.982

dbSNP variants (sampled 300 via entrez): RS1000284609 (5:141927042 T>C), RS1000465484 (5:141922030 C>A,T), RS1000649715 (5:141922859 A>G), RS1000840304 (5:141937998 G>A), RS1000894208 (5:141937598 G>A), RS1001004538 (5:141925649 T>C,G), RS1001233574 (5:141931429 T>C), RS1001326536 (5:141927622 C>G,T), RS1001379079 (5:141927981 T>G), RS1001461217 (5:141926265 C>T), RS1001625024 (5:141933473 C>A), RS1001803026 (5:141925302 C>G,T), RS1001886839 (5:141922008 T>A), RS1001961117 (5:141931365 G>A,T), RS1002016004 (5:141932798 A>G)

Disease associations

OMIM: gene MIM:615741 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST012322_31	Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder	3.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004530	triglyceride measurement
EFO:0005658	response to selective serotonin reuptake inhibitor

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	3
quercitrin	decreases expression	1
manganese chloride	decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
NSC 689534	affects binding, decreases expression	1
Atrazine	decreases expression	1
Catechin	affects cotreatment, decreases expression	1
Copper	affects binding, decreases expression	1
Doxorubicin	decreases expression	1
Manganese	decreases expression, increases abundance	1
Smoke	decreases expression	1
Aflatoxin B1	increases methylation	1
Acrylamide	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_C8SY	HeLa S3 DELE1 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.