DELEC1

Summary

DELEC1 (deleted in esophageal cancer 1, HGNC:23658) is a long non-coding RNA gene on chromosome 9q33.1. Candidate tumor suppressor.

The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.

Source: NCBI Gene 50514 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23658
Approved symbol	DELEC1
Name	deleted in esophageal cancer 1
Location	9q33.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	CTS9
Ensembl gene	ENSG00000173077
Ensembl biotype	lncRNA
OMIM	604767
Entrez	50514
RNAcentral	URS0000DB88E4 — lncRNA, 1251 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000374016, ENST00000477580, ENST00000484171, ENST00000614246, ENST00000647970, ENST00000647996, ENST00000648852, ENST00000649121, ENST00000649565, ENST00000721697, ENST00000766943, ENST00000807886, ENST00000815338, ENST00000825162

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000374016 — 8 exons

Exon	Start	End
ENSE00001462169	115402118	115402644
ENSE00001462170	115376642	115376715
ENSE00001462172	115305906	115305996
ENSE00001462173	115291782	115291936
ENSE00001462174	115233176	115233336
ENSE00001462175	115141818	115141868
ENSE00003834719	115401193	115401310
ENSE00003841122	115400359	115400432

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 78.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5601 / max 161.2266, expressed in 128 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98211	0.2387	63
98212	0.2004	27
98210	0.0525	13
98186	0.0237	9
98198	0.0187	10
98185	0.0176	8
98184	0.0085	3

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.56	gold quality
granulocyte	CL:0000094	73.65	gold quality
leukocyte	CL:0000738	73.11	gold quality
monocyte	CL:0000576	72.63	gold quality
calcaneal tendon	UBERON:0003701	71.42	gold quality
sural nerve	UBERON:0015488	70.40	gold quality
popliteal artery	UBERON:0002250	68.83	gold quality
tibial artery	UBERON:0007610	68.80	gold quality
smooth muscle tissue	UBERON:0001135	65.40	gold quality
stromal cell of endometrium	CL:0002255	65.29	gold quality
ventricular zone	UBERON:0003053	63.93	gold quality
buccal mucosa cell	CL:0002336	63.19	gold quality
aorta	UBERON:0000947	63.06	gold quality
tibial nerve	UBERON:0001323	63.00	gold quality
ganglionic eminence	UBERON:0004023	61.63	gold quality
vermiform appendix	UBERON:0001154	60.46	gold quality
tendon	UBERON:0000043	59.65	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.35	gold quality
left coronary artery	UBERON:0001626	59.08	gold quality
corpus callosum	UBERON:0002336	58.88	gold quality
right coronary artery	UBERON:0001625	58.75	gold quality
right lobe of liver	UBERON:0001114	58.12	gold quality
coronary artery	UBERON:0001621	58.03	gold quality
caecum	UBERON:0001153	57.42	gold quality
upper lobe of left lung	UBERON:0008952	56.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.61	gold quality
endocervix	UBERON:0000458	55.93	gold quality
rectum	UBERON:0001052	55.82	gold quality
upper lobe of lung	UBERON:0008948	55.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.42

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): BHLHE40, CLOCK, HDAC2, ID1, TP53, TP63

Literature-anchored findings (GeneRIF, showing 6)

• DEC1 is a candidate tumor suppressor gene that may be involved in esophageal squamous cell carcinoma development (PMID:15580306)
• Decreased expression of candidate DEC1 is associated with esophageal carcinoma (PMID:17943723)
• DEC1 promoter -249 T>C (rs2012775) polymorphism is functional, modulating susceptibility to squamous cell carcinoma of the head and neck (SCCHN) among non-Hispanic Whites. (PMID:20935061)
• DEC1 is down-regulated and tends to contribute to the migration ability of tumor cell lines; H3 K27 trimethylation potentially plays an important role in the regulation of DEC1 expression (PMID:20975315)
• DEC1 acts as an anti-apoptotic regulator in gastric cancer cells under hypoxia by promoting Survivin expression. (PMID:29204860)
• These results provide evidence that DEC1 and DEC2 have opposite effects on TGFbetainduced epithelialmesenchymal transition in human prostate cancer PC3 cells. (PMID:30106153)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.