DENND3-AS1

Summary

DENND3-AS1 (DENND3 antisense RNA 1, HGNC:55537) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55537
Approved symbol	DENND3-AS1
Name	DENND3 antisense RNA 1
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253210
Ensembl biotype	lncRNA
Entrez	101927963
RNAcentral	URS00026A2657 — lncRNA, 2038 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000517908, ENST00000520885, ENST00000654205, ENST00000664702, ENST00000667929, ENST00000668517, ENST00000690264, ENST00000769370, ENST00000769371

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517908 — 2 exons

Exon	Start	End
ENSE00004130400	141125940	141126471
ENSE00004130409	141129638	141129961

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 87.00.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	87.00	gold quality
bone marrow cell	CL:0002092	86.95	gold quality
bone marrow	UBERON:0002371	86.91	gold quality
monocyte	CL:0000576	86.59	gold quality
leukocyte	CL:0000738	85.98	gold quality
granulocyte	CL:0000094	81.44	gold quality
apex of heart	UBERON:0002098	80.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.29	gold quality
heart left ventricle	UBERON:0002084	77.33	gold quality
spleen	UBERON:0002106	76.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.18	gold quality
lower esophagus	UBERON:0013473	76.13	gold quality
calcaneal tendon	UBERON:0003701	75.68	gold quality
right lung	UBERON:0002167	75.20	gold quality
popliteal artery	UBERON:0002250	75.17	gold quality
tibial artery	UBERON:0007610	75.16	gold quality
tonsil	UBERON:0002372	75.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	74.57	gold quality
right testis	UBERON:0004534	74.49	gold quality
smooth muscle tissue	UBERON:0001135	74.46	gold quality
left testis	UBERON:0004533	74.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.32	gold quality
testis	UBERON:0000473	74.30	gold quality
heart	UBERON:0000948	74.13	gold quality
vermiform appendix	UBERON:0001154	74.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.80	gold quality
upper lobe of left lung	UBERON:0008952	73.26	gold quality
right coronary artery	UBERON:0001625	73.22	gold quality
adipose tissue	UBERON:0001013	73.14	gold quality
pituitary gland	UBERON:0000007	72.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.