DENND5B-AS1

Summary

DENND5B-AS1 (DENND5B antisense RNA 1, HGNC:42517) is a long non-coding RNA gene on chromosome 12p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42517
Approved symbol	DENND5B-AS1
Name	DENND5B antisense RNA 1
Location	12p11.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255867
Ensembl biotype	lncRNA
Entrez	100874249
RNAcentral	URS00004C0EF1 — lncRNA, 564 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000536397, ENST00000537346, ENST00000784765, ENST00000784766, ENST00000784767, ENST00000784768, ENST00000784769, ENST00000784770

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000536397 — 3 exons

Exon	Start	End
ENSE00002230120	31601680	31601854
ENSE00002251777	31589923	31590119
ENSE00002307318	31615160	31615351

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 80.97.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1885 / max 8.3415, expressed in 72 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124932	0.1885	72

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.97	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.57	silver quality
bone marrow cell	CL:0002092	69.73	silver quality
colonic epithelium	UBERON:0000397	68.57	silver quality
muscle of leg	UBERON:0001383	66.34	gold quality
skeletal muscle tissue	UBERON:0001134	66.26	gold quality
gastrocnemius	UBERON:0001388	66.01	gold quality
stromal cell of endometrium	CL:0002255	65.90	gold quality
bone marrow	UBERON:0002371	64.63	gold quality
ventricular zone	UBERON:0003053	64.38	gold quality
ganglionic eminence	UBERON:0004023	63.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.06	gold quality
left ovary	UBERON:0002119	62.82	gold quality
ovary	UBERON:0000992	62.11	gold quality
apex of heart	UBERON:0002098	62.04	gold quality
adrenal tissue	UBERON:0018303	60.79	gold quality
smooth muscle tissue	UBERON:0001135	59.54	gold quality
urinary bladder	UBERON:0001255	59.33	gold quality
prefrontal cortex	UBERON:0000451	58.97	gold quality
pituitary gland	UBERON:0000007	58.51	gold quality
adenohypophysis	UBERON:0002196	58.49	gold quality
right ovary	UBERON:0002118	58.31	gold quality
liver	UBERON:0002107	57.53	gold quality
right atrium auricular region	UBERON:0006631	57.37	gold quality
popliteal artery	UBERON:0002250	57.30	gold quality
tibial artery	UBERON:0007610	57.25	gold quality
heart	UBERON:0000948	57.09	gold quality
granulocyte	CL:0000094	56.62	gold quality
heart left ventricle	UBERON:0002084	56.59	gold quality
left coronary artery	UBERON:0001626	56.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.50

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.