DERPC

Summary

DERPC (DERPC proline and glycine rich nuclear protein, HGNC:54084) is a protein-coding gene on chromosome 16q22.1, encoding Decreased expression in renal and prostate cancer protein (P0CG12). Potential tumor suppressor.

Located in nucleoplasm.

Source: NCBI Gene 113455421 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001002847

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54084
Approved symbol	DERPC
Name	DERPC proline and glycine rich nuclear protein
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000286140
Ensembl biotype	protein_coding
OMIM	621352
Entrez	113455421

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000306585, ENST00000519520

RefSeq mRNA: 7 — MANE Select: NM_001002847 NM_001002847, NM_001040144, NM_001366602, NM_001366603, NM_001366604, NM_001366605, NM_001366606

CCDS: CCDS92188

Canonical transcript exons

ENST00000519520 — 3 exons

Exon	Start	End
ENSE00003606231	69118010	69120649
ENSE00003846850	69121436	69121493
ENSE00003923433	69132484	69132588

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 88.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 51.5794 / max 263.1907, expressed in 1820 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157891	51.5794	1820
157890	1.9919	1160

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	88.38	gold quality
mucosa of transverse colon	UBERON:0004991	87.63	gold quality
ventricular zone	UBERON:0003053	87.32	gold quality
placenta	UBERON:0001987	86.70	gold quality
granulocyte	CL:0000094	86.58	gold quality
lymph node	UBERON:0000029	85.71	gold quality
cortical plate	UBERON:0005343	84.86	gold quality
right lobe of liver	UBERON:0001114	84.66	gold quality
vermiform appendix	UBERON:0001154	84.14	gold quality
colonic epithelium	UBERON:0000397	83.90	gold quality
apex of heart	UBERON:0002098	83.82	gold quality
lower esophagus mucosa	UBERON:0035834	83.20	gold quality
right uterine tube	UBERON:0001302	83.10	gold quality
spleen	UBERON:0002106	82.90	gold quality
islet of Langerhans	UBERON:0000006	82.85	gold quality
gall bladder	UBERON:0002110	82.46	gold quality
fallopian tube	UBERON:0003889	82.37	gold quality
adult mammalian kidney	UBERON:0000082	82.27	gold quality
metanephros cortex	UBERON:0010533	82.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.79	gold quality
smooth muscle tissue	UBERON:0001135	81.78	gold quality
urinary bladder	UBERON:0001255	81.64	gold quality
skin of leg	UBERON:0001511	81.60	gold quality
right lobe of thyroid gland	UBERON:0001119	81.54	gold quality
heart left ventricle	UBERON:0002084	81.30	gold quality
esophagus mucosa	UBERON:0002469	81.28	gold quality
zone of skin	UBERON:0000014	81.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.12	gold quality
esophagus	UBERON:0001043	80.95	gold quality
right coronary artery	UBERON:0001625	80.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• decreased expression of DERPC may be implicated in tumorigenesis of prostate and renal tumors (PMID:12477976)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Derpc	ENSMUSG00000117748
rattus_norvegicus	Chtf8	ENSRNOG00000047246

Protein

Protein identifiers

Decreased expression in renal and prostate cancer protein — P0CG12 (reviewed: P0CG12)

All UniProt accessions (2): P0CG12, L0R4W3

UniProt curated annotations — full annotation on UniProt →

Function. Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.

Subcellular location. Nucleus.

Tissue specificity. Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.

Miscellaneous. Found in a common chromosomal region of deletion in breast cancer.

Similarity. Belongs to the DERPC family.

RefSeq proteins (7): NP_001002847, NP_001035234, NP_001353531, NP_001353532, NP_001353533, NP_001353534, NP_001353535 (=MANE)

Domains & families (InterPro)

UniProt features (12 total): modified residue 4, compositionally biased region 4, region of interest 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CG12-F1	46.73	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 387, 423, 302, 364

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 11 (showing top): chr16q22, CAGGTCC_MIR492, CAGCTTT_MIR320, FEVR_CTNNB1_TARGETS_DN, CTCAGGG_MIR125B_MIR125A, MOHANKUMAR_HOXA1_TARGETS_UP, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GENES_CORRELATED_WITH_MN1_DELETION, GENES_CORRELATED_WITH_PDGFRB_DELETION, GCTTGAA_MIR498, CACTGTG_MIR128A_MIR128B

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (3): nucleoplasm (GO:0005654), extracellular exosome (GO:0070062), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear lumen	1
cellular anatomical structure	1
extracellular vesicle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DERPC	DPEP1	P16444	507
DERPC	RFC1	P35251	296
DERPC	CHTF18	Q8WVB6	280
DERPC	CTCF	P49711	270
DERPC	CDH17	Q12864	221
DERPC	RNF138	Q8WVD3	166
DERPC	UHRF2	Q96PU4	166
DERPC	RNF113A	O15541	166
DERPC	TCEA1	P23193	166
DERPC	CCDC82	Q8N4S0	161
DERPC	CDH1	P12830	149
DERPC	PPM1G	O15355	140
DERPC	RFC3	P40938	132
DERPC	UHRF1	Q96T88	116
DERPC	NCOA5	Q9HCD5	90

IntAct

6 interactions, top by confidence:

A	B	Type	Score
Cdc20	BUB1	psi-mi:“MI:0914”(association)	0.560
Prkcz	GOLIM4	psi-mi:“MI:0914”(association)	0.350
UBA1	NVL	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
KLHL22	TRAV18	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A5PJN8, B1AYB6, B2RWS6, B2RYL1, C7EMF5, F4I171, O48582, O55196, O75157, P0CG10, P0CG12, P0CG14, P18583, P45481, P49750, P62500, P62501, Q09472, Q10571, Q14686, Q148B6, Q15428, Q29W20, Q32KG4, Q3HS82, Q4R837, Q5E9L3, Q5ISE2, Q5JT82, Q5PRE5, Q5R623, Q62203, Q66IN2, Q6JHU9, Q6UX39, Q76KD6, Q86XN7, Q8BH93, Q8NDC0, Q91012

Diamond homologs: B2RYL1, P0CG10, P0CG12, P0CG14

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

568 predictions. Top by Δscore:

Variant	Effect	Δscore
16:69121166:TCGCA:T	acceptor_gain	1.0000
16:69121167:CGCA:C	acceptor_gain	1.0000
16:69121167:CGCAC:C	acceptor_gain	1.0000
16:69121168:GCA:G	acceptor_gain	1.0000
16:69121169:CA:C	acceptor_gain	1.0000
16:69121169:CAC:C	acceptor_gain	1.0000
16:69121170:ACTG:A	acceptor_loss	1.0000
16:69121171:C:CA	acceptor_loss	1.0000
16:69121171:C:CC	acceptor_gain	1.0000
16:69121431:CTTA:C	donor_loss	1.0000
16:69121432:TTA:T	donor_loss	1.0000
16:69121433:TA:T	donor_loss	1.0000
16:69121434:ACC:A	donor_loss	1.0000
16:69121435:C:CG	donor_loss	1.0000
16:69121489:ACAAG:A	acceptor_gain	1.0000
16:69121490:CAAG:C	acceptor_gain	1.0000
16:69121490:CAAGC:C	acceptor_gain	1.0000
16:69121491:AAG:A	acceptor_gain	1.0000
16:69121492:AG:A	acceptor_gain	1.0000
16:69121492:AGC:A	acceptor_loss	1.0000
16:69121493:GC:G	acceptor_loss	1.0000
16:69121494:C:CC	acceptor_gain	1.0000
16:69121494:C:T	acceptor_loss	1.0000
16:69121495:T:A	acceptor_loss	1.0000
16:69120649:CCTT:C	acceptor_gain	0.9900
16:69121048:CTCA:C	donor_loss	0.9900
16:69121051:A:T	donor_loss	0.9900
16:69121052:C:CT	donor_loss	0.9900
16:69121430:ACTT:A	donor_loss	0.9900
16:69121434:A:AC	donor_gain	0.9900

AlphaMissense

3288 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:69120384:C:A	W15C	0.953
16:69120384:C:G	W15C	0.953
16:69120386:A:G	W15R	0.952
16:69120386:A:T	W15R	0.952
16:69118953:A:C	F492L	0.947
16:69118953:A:T	F492L	0.947
16:69118955:A:G	F492L	0.947
16:69119274:G:C	F385L	0.922
16:69119274:G:T	F385L	0.922
16:69119276:A:G	F385L	0.922
16:69118911:G:C	F506L	0.917
16:69118911:G:T	F506L	0.917
16:69118913:A:G	F506L	0.917
16:69119190:G:C	F413L	0.916
16:69119190:G:T	F413L	0.916
16:69119192:A:G	F413L	0.916
16:69119596:A:G	I278T	0.916
16:69120408:G:C	F7L	0.916
16:69120408:G:T	F7L	0.916
16:69120410:A:G	F7L	0.916
16:69120276:G:C	F51L	0.912
16:69120276:G:T	F51L	0.912
16:69120278:A:G	F51L	0.912
16:69119343:A:C	F362L	0.911
16:69119343:A:T	F362L	0.911
16:69119345:A:G	F362L	0.911
16:69119232:G:C	F399L	0.909
16:69119232:G:T	F399L	0.909
16:69119234:A:G	F399L	0.909
16:69120424:T:A	K2I	0.908

dbSNP variants (sampled 300 via entrez): RS1000311617 (16:69119977 G>A,C), RS1000537458 (16:69130925 T>C), RS1000769290 (16:69130528 C>A), RS1000915406 (16:69134408 G>C), RS1001210112 (16:69122032 C>A,T), RS1001282816 (16:69125686 A>C,G), RS1001868649 (16:69125805 G>A,C), RS1001898988 (16:69131595 C>A,G), RS1002171595 (16:69129710 TCTC>T), RS1002359386 (16:69126055 A>G), RS1002374308 (16:69131869 A>T), RS1002433966 (16:69117915 G>A), RS1002568418 (16:69134182 G>A), RS1002621283 (16:69120871 T>C), RS1002887875 (16:69118625 T>C)

Disease associations

OMIM: gene MIM:621352 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.