DGCR11

Summary

DGCR11 (DiGeorge syndrome critical region gene 11, HGNC:17226) is a long non-coding RNA gene on chromosome 22q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17226
Approved symbol	DGCR11
Name	DiGeorge syndrome critical region gene 11
Location	22q11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	DGS-D
Ensembl gene	ENSG00000273311
Ensembl biotype	lncRNA
Entrez	25786
RNAcentral	URS00001458B9 — lncRNA, 2214 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000609958

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000609958 — 1 exons

Exon	Start	End
ENSE00003703284	19046162	19048375

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 88.81.

Top tissues by expression

263 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
diaphragm	UBERON:0001103	88.81	gold quality
buccal mucosa cell	CL:0002336	87.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.36	gold quality
type B pancreatic cell	CL:0000169	84.67	gold quality
olfactory bulb	UBERON:0002264	84.55	gold quality
mucosa of urinary bladder	UBERON:0001259	77.95	silver quality
endometrium epithelium	UBERON:0004811	77.61	gold quality
tongue squamous epithelium	UBERON:0006919	77.30	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.64	gold quality
cervix squamous epithelium	UBERON:0006922	76.33	silver quality
hair follicle	UBERON:0002073	75.17	silver quality
bone marrow cell	CL:0002092	73.52	silver quality
epithelial cell of pancreas	CL:0000083	72.57	silver quality
choroid plexus epithelium	UBERON:0003911	72.04	silver quality
mucosa of sigmoid colon	UBERON:0004993	71.93	silver quality
superficial temporal artery	UBERON:0001614	71.12	silver quality
blood	UBERON:0000178	70.72	gold quality
oral cavity	UBERON:0000167	70.08	silver quality
oocyte	CL:0000023	69.68	gold quality
palpebral conjunctiva	UBERON:0001812	69.55	gold quality
vastus lateralis	UBERON:0001379	69.34	gold quality
epithelium of nasopharynx	UBERON:0001951	69.28	silver quality
colonic mucosa	UBERON:0000317	69.27	gold quality
quadriceps femoris	UBERON:0001377	68.73	gold quality
nephron tubule	UBERON:0001231	68.59	silver quality
lower lobe of lung	UBERON:0008949	68.59	silver quality
CA1 field of hippocampus	UBERON:0003881	68.28	gold quality
kidney epithelium	UBERON:0004819	68.24	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	68.12	gold quality
uterine cervix	UBERON:0000002	68.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.