DGCR5

Summary

DGCR5 (DiGeorge syndrome critical region gene 5, HGNC:16757) is a long non-coding RNA gene on chromosome 22q11.21.

Biomarker of Huntington’s disease.

Source: NCBI Gene 26220 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16757
Approved symbol	DGCR5
Name	DiGeorge syndrome critical region gene 5
Location	22q11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00037, LINC00037, X91348, DGS-A, POM121L5P, DGS-B, RIP
Ensembl gene	ENSG00000273032
Ensembl biotype	lncRNA
OMIM	618040
Entrez	26220
RNAcentral	URS00025E34A4 — lncRNA, 3353 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 68 — 68 lncRNA

ENST00000421572, ENST00000424407, ENST00000438934, ENST00000440005, ENST00000609630, ENST00000609839, ENST00000674913, ENST00000675214, ENST00000675671, ENST00000675978, ENST00000783634, ENST00000783635, ENST00000783636, ENST00000783637, ENST00000783638, ENST00000783639, ENST00000783640, ENST00000783641, ENST00000783642, ENST00000783643, ENST00000783644, ENST00000783645, ENST00000783646, ENST00000783647, ENST00000783648, ENST00000783649, ENST00000783650, ENST00000783651, ENST00000783652, ENST00000783653, ENST00000783654, ENST00000783655, ENST00000783656, ENST00000783657, ENST00000783658, ENST00000783659, ENST00000783660, ENST00000783661, ENST00000783662, ENST00000783663, ENST00000783664, ENST00000783665, ENST00000783666, ENST00000783667, ENST00000783668, ENST00000783669, ENST00000783670, ENST00000783671, ENST00000783672, ENST00000783673, ENST00000783674, ENST00000783675, ENST00000783676, ENST00000783677, ENST00000783678, ENST00000783679, ENST00000783680, ENST00000783681, ENST00000783682, ENST00000783683, ENST00000783684, ENST00000783685, ENST00000783686, ENST00000783687, ENST00000783688, ENST00000783689, ENST00000783690, ENST00000783691

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421572 — 6 exons

Exon	Start	End
ENSE00001679497	18990720	18990924
ENSE00001772133	18988091	18988195
ENSE00001778288	18970515	18970658
ENSE00003900420	18991817	18994615
ENSE00004475037	18987757	18987900
ENSE00004475406	18985836	18986019

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 97.65.

FANTOM5 (CAGE): breadth broad, TPM avg 3.0521 / max 215.3042, expressed in 429 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191029	2.5260	375
191030	0.2305	95
191031	0.1741	41
191028	0.0593	34
191027	0.0445	24
191033	0.0090	3
191032	0.0086	3

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	97.65	gold quality
cerebellar hemisphere	UBERON:0002245	97.40	gold quality
cerebellar cortex	UBERON:0002129	97.30	gold quality
cerebellum	UBERON:0002037	95.38	gold quality
right frontal lobe	UBERON:0002810	94.26	gold quality
prefrontal cortex	UBERON:0000451	90.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.74	gold quality
nucleus accumbens	UBERON:0001882	90.68	gold quality
cortical plate	UBERON:0005343	90.55	gold quality
cingulate cortex	UBERON:0003027	90.25	gold quality
anterior cingulate cortex	UBERON:0009835	90.07	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.72	gold quality
amygdala	UBERON:0001876	89.53	gold quality
caudate nucleus	UBERON:0001873	89.09	gold quality
buccal mucosa cell	CL:0002336	88.62	silver quality
neocortex	UBERON:0001950	88.22	gold quality
frontal cortex	UBERON:0001870	87.87	gold quality
putamen	UBERON:0001874	87.51	gold quality
primary visual cortex	UBERON:0002436	87.33	gold quality
cerebral cortex	UBERON:0000956	86.48	gold quality
telencephalon	UBERON:0001893	86.40	gold quality
brain	UBERON:0000955	85.42	gold quality
forebrain	UBERON:0001890	85.22	gold quality
central nervous system	UBERON:0001017	84.98	gold quality
ganglionic eminence	UBERON:0004023	84.05	gold quality
temporal lobe	UBERON:0001871	83.46	gold quality
Ammon’s horn	UBERON:0001954	82.98	gold quality
ventricular zone	UBERON:0003053	82.41	gold quality
endothelial cell	CL:0000115	81.56	silver quality
occipital lobe	UBERON:0002021	81.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	96.04
E-ANND-3	no	2.41

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): REST

Literature-anchored findings (GeneRIF, showing 24)

• DGCR5 may be a participator in hepatocellular carcinoma (HCC) and can serve as potential biomarker for the diagnosis and prognosis in HCC. (PMID:27898409)
• Gain and loss-of-function studies were performed to verify whether DGCR5 exerts its biological functions through regulating hsa-mir-22-3p in vitro. Overexpression of DGCR5 was able to reverse the tumor inhibitory effect of hsa-mir-22-3p mimics. Furthermore, in vivo tests tumor xenografts were established to detect the function of DGCR5 in lung adenocarcinoma tumorigenesis. (PMID:29030962)
• Over-expression of LINC00037 in LINC00037 knockdown cells restored and enhanced cell proliferation and bind to epidermal growth factor receptor and increase the protein level of epidermal growth factor receptor. (PMID:29393141)
• DGCR5 can act as a crucial regulator of cancer stem cells in non small cell lung cancer by modulating miR-330-5p/CD44 axis. (PMID:29663359)
• we proved that DGCR5 can rescue the inhibited levels of KLF14 repressed by miR-346 mimics in MHCC-97H and Hep3B cells. Taken together, it was indicated in our study that DGCR5 can restrain the progression of HCC through sponging miR-346 and modulating KLF14 in vitro. (PMID:30216442)
• DGCR5 could play tumor suppressive role by targeting Wnt signaling in hepatocellular carcinoma progression. (PMID:30230592)
• our study demonstrated that DGCR5 transcriptionally promotes P21 expression to suppress bladder cancer progression (PMID:30238982)
• DGCR5 negatively regulates miR-30d-5p, and it up-regulates Runx2 through miR-30d-5p, thereby inducing osteogenic differentiation of hMSCs, which may help to delay Postmenopausal osteoporosis development. (PMID:30266402)
• a potential role for DGCR5 in regulating certain Schizophrenia-related genes, was identified. (PMID:30545965)
• that knockdown of DGCR5 suppressed laryngeal carcinoma via targeting miR-195 (PMID:30549038)
• DGCR5 was involved in cervical cancer progression via modulating the Wnt pathway. (PMID:30552671)
• DCGR5 depressed stemness of human laryngeal cancer cells through modulating miR-506 and Wnt signaling pathway. (PMID:30980388)
• LncRNA DGCR5 regulates the non-small cell lung cancer cell growth, migration, and invasion through regulating miR-211-5p/EPHB6 axis. (PMID:31241800)
• DGCR5 suppresses the EMT of pediatric primary glioblastoma multiforme cell and serves as a prognostic biomarker. (PMID:31799672)
• our study demonstrated that downregulated DiGeorge syndrome critical region gene 5 may be a new promising biomarker for predicting clinical progression and prognosis in patients with ovarian cancer. (PMID:31868103)
• Long non-coding RNA DGCR5 incudes tumorigenesis of triple-negative breast cancer by affecting Wnt/beta-catenin signaling pathway. (PMID:32521856)
• LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes. (PMID:33085646)
• DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/beta-catenin pathway. (PMID:33613108)
• Silencing lncRNA-DGCR5 increased trophoblast cell migration, invasion and tube formation, and inhibited cell apoptosis via targeting miR-454-3p/GADD45A axis. (PMID:33973132)
• Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1. (PMID:34099633)
• LncRNA DiGeorge syndrome critical region gene 5: A crucial regulator in malignant tumors. (PMID:34323697)
• Critical Functions of lncRNA DGCR5 in Cancers of the Digestive System. (PMID:34387158)
• LncRNA DGCR5 Silencing Enhances the Radio-Sensitivity of Human Esophageal Squamous Cell Carcinoma via Negatively Regulating the Warburg Effect. (PMID:36730936)
• Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder. (PMID:37962788)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.