DGLUCY

Summary

DGLUCY (D-glutamate cyclase, HGNC:20498) is a protein-coding gene on chromosome 14q32.11, encoding D-glutamate cyclase, mitochondrial (Q7Z3D6). D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.

Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Located in mitochondrion.

Source: NCBI Gene 80017 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 41 total
• MANE Select transcript: NM_001102368

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20498
Approved symbol	DGLUCY
Name	D-glutamate cyclase
Location	14q32.11
Locus type	gene with protein product
Status	Approved
Aliases	FLJ39975
Ensembl gene	ENSG00000133943
Ensembl biotype	protein_coding
OMIM	620716
Entrez	80017

Gene structure

Transcript identifiers

Ensembl transcripts: 172 — 164 protein_coding, 4 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000256324, ENST00000298858, ENST00000412671, ENST00000428926, ENST00000517306, ENST00000517362, ENST00000517518, ENST00000517877, ENST00000518649, ENST00000518665, ENST00000518868, ENST00000518871, ENST00000519019, ENST00000519950, ENST00000519994, ENST00000520130, ENST00000520328, ENST00000521064, ENST00000521077, ENST00000521081, ENST00000521334, ENST00000522170, ENST00000522322, ENST00000522816, ENST00000522837, ENST00000523461, ENST00000523576, ENST00000523771, ENST00000523816, ENST00000523837, ENST00000523879, ENST00000523894, ENST00000524232, ENST00000525393, ENST00000557303, ENST00000887117, ENST00000887118, ENST00000887119, ENST00000887120, ENST00000887121, ENST00000887122, ENST00000887123, ENST00000887124, ENST00000887125, ENST00000887126, ENST00000887127, ENST00000887128, ENST00000887129, ENST00000887130, ENST00000887131, ENST00000887132, ENST00000887133, ENST00000887134, ENST00000887135, ENST00000887136, ENST00000887137, ENST00000887138, ENST00000887139, ENST00000887140, ENST00000887141, ENST00000887142, ENST00000887143, ENST00000887144, ENST00000887145, ENST00000887146, ENST00000887147, ENST00000887148, ENST00000887149, ENST00000887150, ENST00000887151, ENST00000887152, ENST00000887153, ENST00000887154, ENST00000887155, ENST00000887156, ENST00000887157, ENST00000887158, ENST00000887159, ENST00000887160, ENST00000887161, ENST00000887162, ENST00000940050, ENST00000940051, ENST00000940052, ENST00000940053, ENST00000940054, ENST00000947791, ENST00000947792, ENST00000947793, ENST00000947794, ENST00000947795, ENST00000947796, ENST00000947797, ENST00000947798, ENST00000947799, ENST00000947800, ENST00000947801, ENST00000947802, ENST00000947803, ENST00000947804, ENST00000947805, ENST00000947806, ENST00000947807, ENST00000947808, ENST00000947809, ENST00000947810, ENST00000947811, ENST00000947812, ENST00000947813, ENST00000947814, ENST00000947815, ENST00000947816, ENST00000947817, ENST00000947818, ENST00000947819, ENST00000947820, ENST00000947821, ENST00000947822, ENST00000947823, ENST00000947824, ENST00000947825, ENST00000947826, ENST00000947827, ENST00000947828, ENST00000947829, ENST00000947830, ENST00000947831, ENST00000947832, ENST00000947833, ENST00000947834, ENST00000947835, ENST00000947836, ENST00000947837, ENST00000947838, ENST00000947839, ENST00000947840, ENST00000947841, ENST00000947842, ENST00000947843, ENST00000947844, ENST00000947845, ENST00000947846, ENST00000947847, ENST00000947848, ENST00000947849, ENST00000947850, ENST00000947851, ENST00000947852, ENST00000947853, ENST00000947854, ENST00000947855, ENST00000947856, ENST00000947857, ENST00000947858, ENST00000947859, ENST00000947860, ENST00000947861, ENST00000947862, ENST00000947863, ENST00000947864, ENST00000947865, ENST00000947866, ENST00000947867, ENST00000947868, ENST00000947869, ENST00000947870, ENST00000947871, ENST00000947872, ENST00000947873, ENST00000947874, ENST00000947875, ENST00000947877

RefSeq mRNA: 12 — MANE Select: NM_001102368 NM_001102366, NM_001102367, NM_001102368, NM_001102369, NM_001286470, NM_001286471, NM_001286472, NM_001286473, NM_001358310, NM_001358311, NM_001358312, NM_024952

CCDS: CCDS32141, CCDS41979, CCDS45150, CCDS66693, CCDS73677

Canonical transcript exons

ENST00000256324 — 14 exons

Exon	Start	End
ENSE00001196619	91157639	91157690
ENSE00003261886	91224684	91225632
ENSE00003496282	91188910	91189170
ENSE00003544160	91160266	91160397
ENSE00003566785	91175934	91176056
ENSE00003600050	91204706	91204825
ENSE00003648918	91181186	91181389
ENSE00003667566	91199757	91199905
ENSE00003685755	91215405	91215556
ENSE00003784322	91167225	91167378
ENSE00003785266	91173289	91173439
ENSE00003787244	91196375	91196474
ENSE00003790351	91170003	91170201
ENSE00003906797	91114073	91114283

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 98.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.6277 / max 343.3181, expressed in 1796 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141048	17.4290	1678
141050	4.1371	1391
141045	2.5922	967
141053	1.3481	589
141049	1.2708	631
141054	0.9992	386
141046	0.8820	483
141051	0.6044	396
141055	0.4073	82
141052	0.3971	218

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	98.42	gold quality
heart left ventricle	UBERON:0002084	97.28	gold quality
right atrium auricular region	UBERON:0006631	97.24	gold quality
cardiac ventricle	UBERON:0002082	97.21	gold quality
cardiac atrium	UBERON:0002081	96.89	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.84	gold quality
triceps brachii	UBERON:0001509	96.12	gold quality
heart	UBERON:0000948	95.92	gold quality
gastrocnemius	UBERON:0001388	95.83	gold quality
body of tongue	UBERON:0011876	95.78	gold quality
muscle of leg	UBERON:0001383	95.74	gold quality
body of stomach	UBERON:0001161	95.66	gold quality
fundus of stomach	UBERON:0001160	95.62	gold quality
granulocyte	CL:0000094	95.51	gold quality
muscle organ	UBERON:0001630	95.50	gold quality
skeletal muscle organ	UBERON:0014892	95.49	gold quality
rectum	UBERON:0001052	95.28	gold quality
skeletal muscle tissue	UBERON:0001134	95.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.21	gold quality
lower esophagus	UBERON:0013473	95.20	gold quality
right uterine tube	UBERON:0001302	95.12	gold quality
stomach	UBERON:0000945	95.04	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.02	gold quality
transverse colon	UBERON:0001157	94.99	gold quality
blood	UBERON:0000178	94.94	gold quality
biceps brachii	UBERON:0001507	94.90	gold quality
colonic epithelium	UBERON:0000397	94.79	gold quality
right adrenal gland cortex	UBERON:0035827	94.76	gold quality
sural nerve	UBERON:0015488	94.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting DGLUCY, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-7156-5P	99.64	68.81	1369
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-7153-3P	99.00	65.35	608
HSA-MIR-5007-5P	97.95	64.71	614
HSA-MIR-4294	97.86	65.72	1110
HSA-MIR-924	97.78	66.21	681
HSA-MIR-4671-5P	97.10	65.70	93
HSA-MIR-2355-3P	96.84	68.54	909
HSA-MIR-3657	96.33	66.29	608

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dglucy	ENSDARG00000005179
mus_musculus	Dglucy	ENSMUSG00000021185
rattus_norvegicus	Dglucy	ENSRNOG00000004442

Protein

Protein identifiers

D-glutamate cyclase, mitochondrial — Q7Z3D6 (reviewed: Q7Z3D6)

All UniProt accessions (19): A0A0C4DGD4, A0A0C4DGD8, Q7Z3D6, E5RFT5, E5RFZ6, E5RGN8, E5RGP9, E5RHG2, E5RIL4, E5RIU5, E5RJ62, E5RJ87, E5RJD1, E5RJL7, E5RK14, E5RK56, H0YB09, H0YB11, H0YB62

UniProt curated annotations — full annotation on UniProt →

Function. D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.

Subcellular location. Mitochondrion matrix.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the D-glutamate cyclase family.

Isoforms (6)

UniProt ID	Names	Canonical?
Q7Z3D6-1	1	yes
Q7Z3D6-2	2
Q7Z3D6-3	3
Q7Z3D6-4	4
Q7Z3D6-5	5
Q7Z3D6-6	6

RefSeq proteins (12): NP_001095836, NP_001095837, NP_001095838, NP_001095839, NP_001273399, NP_001273400, NP_001273401, NP_001273402, NP_001345239, NP_001345240, NP_001345241, NP_079228 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009906	D-Glu_cyclase	Domain
IPR017135	D-Glu_cyclase_mito	Family
IPR025504	GLUCM_C	Domain
IPR038021	Putative_hydro-lyase	Homologous_superfamily

Pfam: PF07286, PF14336

Catalyzed reactions (Rhea), 1 shown:

• D-glutamate = 5-oxo-D-proline + H2O (RHEA:22360)

UniProt features (21 total): splice variant 7, sequence variant 6, sequence conflict 6, transit peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z3D6-F1	86.54	0.68

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 169 (showing top): GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS, GOBP_GLUTAMATE_METABOLIC_PROCESS, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS, GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, GOMF_HYDRO_LYASE_ACTIVITY, CTGYNNCTYTAA_UNKNOWN, chr14q32, GOCC_MITOCHONDRIAL_MATRIX, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, LINDGREN_BLADDER_CANCER_CLUSTER_1_UP, CAMP_UP.V1_UP, ARID5B_TARGET_GENES

GO Biological Process (1): glutamate metabolic process (GO:0006536)

GO Molecular Function (3): D-glutamate cyclase activity (GO:0047820), protein binding (GO:0005515), lyase activity (GO:0016829)

GO Cellular Component (2): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
amino acid metabolic process	1
dicarboxylic acid metabolic process	1
cyclase activity	1
hydro-lyase activity	1
binding	1
catalytic activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

482 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DGLUCY	NSFL1C	Q9UNZ2	492
DGLUCY	STARD4	Q96DR4	469
DGLUCY	EPB42	P16452	459
DGLUCY	C8orf82	Q6P1X6	448
DGLUCY	C15orf40	Q8WUR7	447
DGLUCY	MKNK2	Q9HBH9	429
DGLUCY	JAM3	Q9BX67	410
DGLUCY	A0A0U1RQV1	A0A0U1RQV1	400
DGLUCY	IRAK2	O43187	394
DGLUCY	ADHFE1	Q8IWW8	382
DGLUCY	LRRN4CL	Q8ND94	379
DGLUCY	ZNF780A	O75290	377
DGLUCY	C2orf69	Q8N8R5	370
DGLUCY	C5orf63	A6NC05	370
DGLUCY	GCDH	Q92947	366

IntAct

24 interactions, top by confidence:

A	B	Type	Score
PSMA3	DGLUCY	psi-mi:“MI:0915”(physical association)	0.560
DGLUCY	PSMA3	psi-mi:“MI:0915”(physical association)	0.560
DGLUCY	BOLA3	psi-mi:“MI:0914”(association)	0.350
NME4	NRDC	psi-mi:“MI:0914”(association)	0.350
DGLUCY	SLC25A6	psi-mi:“MI:0914”(association)	0.350
NDUFAF8	ALDH1L1	psi-mi:“MI:0914”(association)	0.350
PAK5	HTRA2	psi-mi:“MI:0914”(association)	0.350
DGLUCY	MSRB2	psi-mi:“MI:0914”(association)	0.350
NDUFAF8	NDUFAB1	psi-mi:“MI:0914”(association)	0.350
	DENND11	psi-mi:“MI:0914”(association)	0.350
	NUDT19	psi-mi:“MI:0914”(association)	0.350
GPR182	SLC12A8	psi-mi:“MI:0914”(association)	0.350
YARS2	VWA8	psi-mi:“MI:0914”(association)	0.350
FAHD1	VWA8	psi-mi:“MI:0914”(association)	0.350
GPR45	VWA8	psi-mi:“MI:0914”(association)	0.350
NIPSNAP3A	NUDT19	psi-mi:“MI:0914”(association)	0.350
P2RY8	BTAF1	psi-mi:“MI:0914”(association)	0.350
NIPSNAP3B	CLUH	psi-mi:“MI:0914”(association)	0.350
FECH	GTPBP10	psi-mi:“MI:0914”(association)	0.350
DGLUCY		psi-mi:“MI:0915”(physical association)	0.000
LCOR	DGLUCY	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (24): C14orf159 (Two-hybrid), C14orf159 (Affinity Capture-MS), MSRB2 (Affinity Capture-MS), BOLA3 (Affinity Capture-MS), C14orf159 (Affinity Capture-MS), SLC25A6 (Affinity Capture-MS), C14orf159 (Affinity Capture-MS), C14orf159 (Positive Genetic), C14orf159 (Affinity Capture-MS), C14orf159 (Affinity Capture-MS), C14orf159 (Affinity Capture-RNA), C14orf159 (Affinity Capture-MS), C14orf159 (Affinity Capture-MS), C14orf159 (Affinity Capture-MS), C14orf159 (Affinity Capture-MS)

ESM2 similar proteins: A0A1S4BZI5, A0A1S4CB73, B0F481, D2HRF1, F4I933, F4IY62, F4JKB6, F4JVN6, O23324, O23553, O80585, O82043, O82768, P10349, P30706, P36428, P42898, Q01292, Q05758, Q0J6P7, Q10S55, Q2QTL0, Q39639, Q42713, Q43307, Q43822, Q43870, Q5I598, Q5U2Z5, Q60HE5, Q66GI4, Q75HE6, Q7Z3D6, Q80YD1, Q8BH86, Q8H0W0, Q8K224, Q8RWG3, Q8VYL1, Q944I4

Diamond homologs: A0AY13, A0K0Y1, A0LNR4, A0ZZH5, A1AYU1, A1SCV3, A1TSX9, A1WS32, A3M452, A4FA00, A4JL57, A4QGU3, A4T1E2, A4VN63, A4YR32, A5EFR6, A6LX31, A6TSF6, A6V669, A6W5D4, A7IFF8, A7Z1F3, A8FA09, A8HRQ8, A8LLX6, A8LPN3, A9AQ22, A9BMR1, A9H2B4, A9ILF0, B0K189, B0K9K2, B0UBJ1, B0VAY4, B0VRR2, B1K6C3, B1KND9, B1LSM6, B1VIF7, B1YZG1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

41 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	18
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3409 predictions. Top by Δscore:

Variant	Effect	Δscore
14:91160264:A:AG	acceptor_gain	1.0000
14:91160265:G:GG	acceptor_gain	1.0000
14:91160394:GGAG:G	donor_gain	1.0000
14:91160395:GAG:G	donor_gain	1.0000
14:91160395:GAGG:G	donor_gain	1.0000
14:91160396:AGGTA:A	donor_loss	1.0000
14:91160397:GGTA:G	donor_loss	1.0000
14:91160398:G:GG	donor_gain	1.0000
14:91160398:GTA:G	donor_loss	1.0000
14:91160399:T:A	donor_loss	1.0000
14:91188908:AG:A	acceptor_gain	1.0000
14:91188909:GG:G	acceptor_gain	1.0000
14:91189166:GCAAG:G	donor_gain	1.0000
14:91189169:AGG:A	donor_loss	1.0000
14:91189171:GTAA:G	donor_loss	1.0000
14:91189172:T:A	donor_loss	1.0000
14:91196373:A:G	acceptor_gain	1.0000
14:91196473:AGG:A	donor_loss	1.0000
14:91196475:G:A	donor_loss	1.0000
14:91199751:C:A	acceptor_gain	1.0000
14:91199752:GGCA:G	acceptor_loss	1.0000
14:91199753:GCAG:G	acceptor_loss	1.0000
14:91199755:A:AG	acceptor_gain	1.0000
14:91199755:A:C	acceptor_loss	1.0000
14:91199756:G:GA	acceptor_gain	1.0000
14:91199756:GA:G	acceptor_gain	1.0000
14:91199756:GAT:G	acceptor_gain	1.0000
14:91199756:GATT:G	acceptor_gain	1.0000
14:91199756:GATTT:G	acceptor_gain	1.0000
14:91199901:AACTG:A	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000001054 (14:91071041 T>C), RS1000026482 (14:91159046 G>A), RS1000045287 (14:91118678 A>G), RS1000049388 (14:91078428 T>C,G), RS1000103424 (14:91072354 A>G), RS1000132106 (14:91133469 C>G,T), RS1000147028 (14:91182367 A>G), RS1000165267 (14:91191295 A>G), RS1000171131 (14:91213016 A>T), RS1000179691 (14:91178473 A>G), RS1000198328 (14:91193894 C>A,T), RS1000229544 (14:91218252 A>C,T), RS1000230719 (14:91094098 C>T), RS1000288088 (14:91093876 G>C,T), RS1000288261 (14:91143244 C>T)

Disease associations

OMIM: gene MIM:620716 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST003818_68	Resting heart rate	5.000000e-09
GCST004097_2	Response to platinum-based neoadjuvant chemotherapy in cervical cancer	7.000000e-06
GCST005956_47	Waist-to-hip ratio adjusted for BMI	7.000000e-07
GCST005962_28	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	7.000000e-07
GCST009733_10	Urinary metabolite levels in chronic kidney disease	2.000000e-37
GCST90013663_46	Alanine aminotransferase levels	1.000000e-09
GCST90013664_22	Aspartate aminotransferase levels	2.000000e-08
GCST90020024_475	A body shape index	2.000000e-13
GCST90020024_476	A body shape index	1.000000e-09
GCST90020025_432	Waist-to-hip ratio adjusted for BMI	4.000000e-22
GCST90020025_433	Waist-to-hip ratio adjusted for BMI	7.000000e-12
GCST90020025_434	Waist-to-hip ratio adjusted for BMI	3.000000e-08
GCST90020027_612	Waist-hip index	4.000000e-08
GCST90020027_685	Waist-hip index	9.000000e-23
GCST90020027_686	Waist-hip index	3.000000e-12
GCST90020029_276	Waist circumference adjusted for body mass index	4.000000e-13
GCST90020029_277	Waist circumference adjusted for body mass index	4.000000e-09

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0007943	response to platinum-based neoadjuvant chemotherapy
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0005116	urinary metabolite measurement
EFO:0004736	aspartate aminotransferase measurement
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	3
bisphenol A	increases expression, decreases methylation	2
methacrylaldehyde	affects cotreatment, decreases expression, increases oxidation, increases abundance	2
perfluorooctane sulfonic acid	decreases expression, increases expression	2
Acetaminophen	decreases expression	2
Acrolein	affects cotreatment, decreases expression, increases oxidation, increases abundance	2
Benzo(a)pyrene	affects methylation, decreases expression, decreases methylation, increases methylation	2
Ozone	increases abundance, affects cotreatment, decreases expression, increases oxidation	2
Tobacco Smoke Pollution	decreases expression	2
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
perfluorooctanoic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
perfluorohexanesulfonic acid	decreases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Air Pollutants	increases abundance, increases oxidation, affects cotreatment, decreases expression	1
Carbamazepine	affects expression	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Gallic Acid	decreases expression	1
Naled	affects expression	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SG03	HAP1 C14orf159 (-) 1	Cancer cell line	Male
CVCL_XM17	HAP1 C14orf159 (-) 2	Cancer cell line	Male
CVCL_XM18	HAP1 C14orf159 (-) 3	Cancer cell line	Male
CVCL_XM19	HAP1 C14orf159 (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.