DGUOK-AS1

Summary

DGUOK-AS1 (DGUOK antisense RNA 1, HGNC:43441) is a long non-coding RNA gene on chromosome 2p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43441
Approved symbol	DGUOK-AS1
Name	DGUOK antisense RNA 1
Location	2p13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237883
Ensembl biotype	lncRNA
Entrez	100874048
RNAcentral	URS000075AA95 — lncRNA, 582 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 44 lncRNA

ENST00000413452, ENST00000439192, ENST00000453103, ENST00000667561, ENST00000685756, ENST00000689317, ENST00000701457, ENST00000701478, ENST00000702742, ENST00000702803, ENST00000804860, ENST00000804861, ENST00000804862, ENST00000804863, ENST00000804864, ENST00000804865, ENST00000804866, ENST00000804867, ENST00000804868, ENST00000804869, ENST00000804870, ENST00000804871, ENST00000804872, ENST00000804873, ENST00000804874, ENST00000804875, ENST00000804876, ENST00000804877, ENST00000804878, ENST00000804879, ENST00000804880, ENST00000804881, ENST00000804882, ENST00000804883, ENST00000804884, ENST00000804885, ENST00000804886, ENST00000804887, ENST00000804888, ENST00000804889, ENST00000804890, ENST00000804891, ENST00000804892, ENST00000804893

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413452 — 2 exons

Exon	Start	End
ENSE00004196574	73981109	73981757
ENSE00004196609	73957962	73958207

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 91.24.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9349 / max 29.4849, expressed in 412 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29154	0.4866	253
29153	0.3743	185
29155	0.0740	34

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.24	gold quality
mucosa of transverse colon	UBERON:0004991	84.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.63	gold quality
lower esophagus mucosa	UBERON:0035834	83.48	gold quality
endometrium	UBERON:0001295	83.39	gold quality
esophagus mucosa	UBERON:0002469	82.14	gold quality
rectum	UBERON:0001052	81.87	gold quality
skin of abdomen	UBERON:0001416	81.86	gold quality
zone of skin	UBERON:0000014	80.80	gold quality
minor salivary gland	UBERON:0001830	80.27	gold quality
skin of leg	UBERON:0001511	80.07	gold quality
saliva-secreting gland	UBERON:0001044	79.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.20	gold quality
monocyte	CL:0000576	78.72	gold quality
leukocyte	CL:0000738	78.04	gold quality
adenohypophysis	UBERON:0002196	77.75	gold quality
vagina	UBERON:0000996	77.72	gold quality
pituitary gland	UBERON:0000007	77.26	gold quality
left adrenal gland cortex	UBERON:0035825	76.96	gold quality
prostate gland	UBERON:0002367	76.82	gold quality
transverse colon	UBERON:0001157	76.65	gold quality
esophagus	UBERON:0001043	76.52	gold quality
granulocyte	CL:0000094	76.51	gold quality
spleen	UBERON:0002106	76.08	gold quality
right adrenal gland	UBERON:0001233	75.92	gold quality
left adrenal gland	UBERON:0001234	75.89	gold quality
right ovary	UBERON:0002118	75.61	gold quality
ectocervix	UBERON:0012249	75.55	gold quality
body of stomach	UBERON:0001161	75.44	gold quality
blood	UBERON:0000178	75.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.73

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• DGUOK-AS1 promotes cell proliferation in cervical cancer via acting as a ceRNA of miR-653-5p. (PMID:32283566)
• DGUOK-AS1 promotes cervical squamous cell carcinoma progression by suppressing miR-499a-5p that targets SPRR1B in vitro. (PMID:34808501)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.