DHRS4-AS1

Summary

DHRS4-AS1 (DHRS4 antisense RNA 1, HGNC:23175) is a long non-coding RNA gene on chromosome 14q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23175
Approved symbol	DHRS4-AS1
Name	DHRS4 antisense RNA 1
Location	14q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRO1488, AS1DHRS4
Ensembl gene	ENSG00000215256
Ensembl biotype	lncRNA
OMIM	616925
Entrez	55449
RNAcentral	URS0000759C46 — lncRNA, 3052 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 44 lncRNA

ENST00000399886, ENST00000553454, ENST00000554036, ENST00000555045, ENST00000556379, ENST00000558423, ENST00000654375, ENST00000656462, ENST00000656761, ENST00000660207, ENST00000663118, ENST00000666884, ENST00000667602, ENST00000671346, ENST00000671411, ENST00000671431, ENST00000671464, ENST00000690764, ENST00000701299, ENST00000701377, ENST00000701562, ENST00000830183, ENST00000830184, ENST00000830185, ENST00000830186, ENST00000830187, ENST00000830188, ENST00000830189, ENST00000830190, ENST00000830191, ENST00000830192, ENST00000830193, ENST00000830194, ENST00000830195, ENST00000830196, ENST00000830197, ENST00000830198, ENST00000830199, ENST00000830200, ENST00000830201, ENST00000830202, ENST00000830203, ENST00000830204, ENST00000830205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000399886 — 2 exons

Exon	Start	End
ENSE00003986026	23954125	23954204
ENSE00004244360	23940345	23941158

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 89.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5331 / max 54.2742, expressed in 1612 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142520	3.5667	1551
142519	0.7934	437
142521	0.1730	71

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	89.46	gold quality
liver	UBERON:0002107	88.92	gold quality
islet of Langerhans	UBERON:0000006	88.59	gold quality
right lobe of liver	UBERON:0001114	88.49	gold quality
adult mammalian kidney	UBERON:0000082	86.82	gold quality
kidney	UBERON:0002113	85.95	gold quality
pancreas	UBERON:0001264	85.83	gold quality
rectum	UBERON:0001052	85.10	gold quality
cortex of kidney	UBERON:0001225	85.07	gold quality
ventricular zone	UBERON:0003053	84.88	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.60	gold quality
body of pancreas	UBERON:0001150	84.51	gold quality
caudate nucleus	UBERON:0001873	84.05	gold quality
prefrontal cortex	UBERON:0000451	83.55	gold quality
putamen	UBERON:0001874	83.16	gold quality
fallopian tube	UBERON:0003889	83.00	gold quality
amygdala	UBERON:0001876	82.82	gold quality
temporal lobe	UBERON:0001871	82.80	gold quality
endometrium	UBERON:0001295	82.74	gold quality
nucleus accumbens	UBERON:0001882	82.68	gold quality
smooth muscle tissue	UBERON:0001135	82.61	gold quality
ganglionic eminence	UBERON:0004023	82.59	gold quality
leukocyte	CL:0000738	82.33	gold quality
ovary	UBERON:0000992	82.13	gold quality
hypothalamus	UBERON:0001898	82.13	gold quality
stromal cell of endometrium	CL:0002255	82.12	gold quality
substantia nigra	UBERON:0002038	82.10	gold quality
monocyte	CL:0000576	82.04	gold quality
Ammon’s horn	UBERON:0001954	81.98	gold quality
left ovary	UBERON:0002119	81.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA DHRS4 antisense RNA 1 inhibits ectopic endometrial cell proliferation, migration, and invasion in endometriosis by regulating microRNA-139-5p expression. (PMID:35414313)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.