DIAPH1-AS1

Summary

DIAPH1-AS1 (DIAPH1 antisense RNA 1, HGNC:40177) is a long non-coding RNA gene on chromosome 5q31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40177
Approved symbol	DIAPH1-AS1
Name	DIAPH1 antisense RNA 1
Location	5q31.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246422
Ensembl biotype	lncRNA
Entrez	100505658
RNAcentral	URS000075B908 — lncRNA, 2477 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000502205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000502205 — 3 exons

Exon	Start	End
ENSE00001963409	141558311	141558487
ENSE00001971053	141563065	141565263
ENSE00001990913	141561802	141561905

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 80.96.

Top tissues by expression

173 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	80.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.77	silver quality
bone marrow cell	CL:0002092	72.26	silver quality
colonic epithelium	UBERON:0000397	66.30	silver quality
sural nerve	UBERON:0015488	61.96	silver quality
hindlimb stylopod muscle	UBERON:0004252	61.61	gold quality
calcaneal tendon	UBERON:0003701	60.21	gold quality
sperm	CL:0000019	56.97	silver quality
ganglionic eminence	UBERON:0004023	56.65	silver quality
tonsil	UBERON:0002372	56.28	silver quality
uterine cervix	UBERON:0000002	54.82	silver quality
testis	UBERON:0000473	54.51	gold quality
left testis	UBERON:0004533	54.28	gold quality
leukocyte	CL:0000738	53.53	silver quality
right testis	UBERON:0004534	53.38	gold quality
monocyte	CL:0000576	53.33	silver quality
tendon	UBERON:0000043	53.23	gold quality
blood	UBERON:0000178	50.93	gold quality
adrenal tissue	UBERON:0018303	50.85	silver quality
liver	UBERON:0002107	50.27	gold quality
adrenal gland	UBERON:0002369	50.03	silver quality
skeletal muscle tissue	UBERON:0001134	48.60	gold quality
stomach	UBERON:0000945	48.45	gold quality
gall bladder	UBERON:0002110	48.16	silver quality
adult mammalian kidney	UBERON:0000082	48.06	gold quality
thyroid gland	UBERON:0002046	47.57	silver quality
gastrocnemius	UBERON:0001388	46.78	gold quality
kidney	UBERON:0002113	45.78	gold quality
esophagus	UBERON:0001043	45.58	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• WTAP-mediated m(6)A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis. (PMID:34999731)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.