DIAPH2-AS1

Summary

DIAPH2-AS1 (DIAPH2 antisense RNA 1, HGNC:16972) is a long non-coding RNA gene on chromosome Xq21.33. May function as an early signal that helps mediate the activation of T-cells.

Predicted to be involved in signal transduction.

Source: NCBI Gene 10824 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16972
Approved symbol	DIAPH2-AS1
Name	DIAPH2 antisense RNA 1
Location	Xq21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236256
Ensembl biotype	lncRNA
OMIM	300347
Entrez	10824
RNAcentral	URS00007E3796 — lncRNA, 977 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000439759, ENST00000445414, ENST00000542084, ENST00000579945, ENST00000744263, ENST00000744264, ENST00000744265, ENST00000744266, ENST00000744267, ENST00000744268, ENST00000744269, ENST00000744270

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000439759 — 6 exons

Exon	Start	End
ENSE00001600766	97453979	97454018
ENSE00001618650	97442057	97442119
ENSE00001764622	97442679	97442811
ENSE00001777499	97431286	97431776
ENSE00001789110	97564380	97564505
ENSE00002693265	97533312	97533429

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 80.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.0840 / max 1262.1193, expressed in 114 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199913	0.8433	8
199914	0.2317	107
199912	0.0090	1

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	80.69	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.92	silver quality
colonic epithelium	UBERON:0000397	74.11	gold quality
calcaneal tendon	UBERON:0003701	71.97	gold quality
tendon	UBERON:0000043	71.24	gold quality
sural nerve	UBERON:0015488	71.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.53	gold quality
tendon of biceps brachii	UBERON:0008188	69.83	silver quality
ganglionic eminence	UBERON:0004023	68.01	gold quality
lower esophagus mucosa	UBERON:0035834	64.22	gold quality
esophagus mucosa	UBERON:0002469	63.16	gold quality
monocyte	CL:0000576	63.08	gold quality
bone marrow cell	CL:0002092	62.98	silver quality
mononuclear cell	CL:0000842	62.95	gold quality
ventricular zone	UBERON:0003053	62.58	gold quality
endometrium epithelium	UBERON:0004811	60.27	gold quality
gall bladder	UBERON:0002110	60.02	gold quality
esophagus	UBERON:0001043	58.84	gold quality
adrenal tissue	UBERON:0018303	58.62	gold quality
ectocervix	UBERON:0012249	57.58	gold quality
mucosa of transverse colon	UBERON:0004991	57.23	gold quality
cortical plate	UBERON:0005343	56.65	gold quality
vagina	UBERON:0000996	56.56	gold quality
granulocyte	CL:0000094	56.54	gold quality
muscle of leg	UBERON:0001383	56.32	gold quality
mucosa of stomach	UBERON:0001199	55.85	gold quality
tonsil	UBERON:0002372	55.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	55.50	gold quality
right lobe of liver	UBERON:0001114	55.33	gold quality
gastrocnemius	UBERON:0001388	55.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Two transcription factors, HOXD8 and Lhx3, predicted to regulate the expression of lncRNAs, were also selected. Using RNA interference technology, HOXD8 and Lhx3 were found to positively regulate DIAPH2-AS1 and RP11-445K13.2 in HTR-8/SVneo cells (PMID:30626726)
• Reduced Zn[2+] promotes retinal ganglion cells survival and optic nerve regeneration after injury through inhibiting autophagy mediated by ROS/Nrf2. (PMID:38134974)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.