DIAPH3-AS2

Summary

DIAPH3-AS2 (DIAPH3 antisense RNA 2, HGNC:39916) is a long non-coding RNA gene on chromosome 13q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39916
Approved symbol	DIAPH3-AS2
Name	DIAPH3 antisense RNA 2
Location	13q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223815
Ensembl biotype	lncRNA
Entrez	100874196
RNAcentral	URS000024401A — lncRNA, 367 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000428656, ENST00000780161, ENST00000780162, ENST00000780163, ENST00000780164

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000428656 — 3 exons

Exon	Start	End
ENSE00001667026	60147255	60147345
ENSE00004151176	60153396	60153689
ENSE00004151177	60144613	60144863

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 84.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0079 / max 9.0217, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135275	0.0079	3

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	84.10	gold quality
testis	UBERON:0000473	83.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.67	gold quality
right testis	UBERON:0004534	82.92	gold quality
bone marrow cell	CL:0002092	66.08	silver quality
multicellular organism	UBERON:0000468	65.00	gold quality
adrenal tissue	UBERON:0018303	64.66	gold quality
ganglionic eminence	UBERON:0004023	64.34	gold quality
colonic epithelium	UBERON:0000397	61.94	silver quality
bone marrow	UBERON:0002371	57.53	silver quality
lung	UBERON:0002048	56.65	gold quality
tibial nerve	UBERON:0001323	53.60	gold quality
monocyte	CL:0000576	51.93	silver quality
gastrocnemius	UBERON:0001388	50.45	gold quality
kidney	UBERON:0002113	49.90	silver quality
heart	UBERON:0000948	49.52	gold quality
blood	UBERON:0000178	49.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	49.38	gold quality
intestine	UBERON:0000160	46.86	silver quality
body of pancreas	UBERON:0001150	46.43	silver quality
stomach	UBERON:0000945	46.19	gold quality
right lobe of liver	UBERON:0001114	45.02	silver quality
tibial artery	UBERON:0007610	44.98	silver quality
thoracic mammary gland	UBERON:0005200	44.77	silver quality
colon	UBERON:0001155	44.44	silver quality
ascending aorta	UBERON:0001496	43.54	silver quality
right atrium auricular region	UBERON:0006631	43.48	silver quality
esophagus	UBERON:0001043	43.15	silver quality
transverse colon	UBERON:0001157	43.02	silver quality
muscle layer of sigmoid colon	UBERON:0035805	41.95	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.