DINOL

Summary

DINOL (damage induced long noncoding RNA, HGNC:53146) is a long non-coding RNA gene on chromosome 6p21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53146
Approved symbol	DINOL
Name	damage induced long noncoding RNA
Location	6p21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	DINO
Ensembl gene	ENSG00000285244
Ensembl biotype	lncRNA
Entrez	108783646
RNAcentral	URS0000576071 — lncRNA, 951 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000643333, ENST00000839528

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000643333 — 1 exons

Exon	Start	End
ENSE00003826350	36677609	36678559

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 94.22.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.22	gold quality
bone marrow cell	CL:0002092	71.87	gold quality
right uterine tube	UBERON:0001302	67.74	gold quality
sural nerve	UBERON:0015488	64.81	silver quality
bone marrow	UBERON:0002371	63.41	gold quality
ascending aorta	UBERON:0001496	59.27	gold quality
thoracic aorta	UBERON:0001515	58.87	gold quality
islet of Langerhans	UBERON:0000006	57.20	gold quality
stromal cell of endometrium	CL:0002255	57.02	gold quality
descending thoracic aorta	UBERON:0002345	56.95	gold quality
fallopian tube	UBERON:0003889	56.66	gold quality
popliteal artery	UBERON:0002250	56.33	gold quality
tibial artery	UBERON:0007610	56.29	gold quality
gastrocnemius	UBERON:0001388	55.19	gold quality
muscle of leg	UBERON:0001383	55.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.97	gold quality
body of pancreas	UBERON:0001150	54.64	gold quality
right lung	UBERON:0002167	54.63	gold quality
left uterine tube	UBERON:0001303	54.24	gold quality
leukocyte	CL:0000738	54.21	gold quality
skeletal muscle tissue	UBERON:0001134	53.82	silver quality
monocyte	CL:0000576	53.81	gold quality
liver	UBERON:0002107	53.78	gold quality
right lobe of liver	UBERON:0001114	53.49	gold quality
vermiform appendix	UBERON:0001154	53.06	gold quality
smooth muscle tissue	UBERON:0001135	52.56	gold quality
apex of heart	UBERON:0002098	52.23	gold quality
prefrontal cortex	UBERON:0000451	52.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	51.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage. (PMID:27787509)
• KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. (PMID:32269126)
• Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling. (PMID:32546626)
• p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino. (PMID:34192538)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.