DIO2-AS1

Summary

DIO2-AS1 (DIO2 antisense RNA 1, HGNC:44153) is a long non-coding RNA gene on chromosome 14q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44153
Approved symbol	DIO2-AS1
Name	DIO2 antisense RNA 1
Location	14q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258766
Ensembl biotype	lncRNA
Entrez	100628307
RNAcentral	URS000075EEB7 — lncRNA, 1625 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000553979, ENST00000726039, ENST00000726040, ENST00000726041, ENST00000726042, ENST00000808004

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553979 — 9 exons

Exon	Start	End
ENSE00002430323	80403120	80403281
ENSE00002434911	80393983	80394186
ENSE00002436697	80373387	80373596
ENSE00002449834	80455128	80455469
ENSE00002454840	80211419	80211488
ENSE00002487980	80385848	80385916
ENSE00002494735	80397030	80397179
ENSE00002516411	80358701	80358982
ENSE00002524111	80219390	80219497

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 59.66.

Top tissues by expression

159 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagus mucosa	UBERON:0002469	59.66	gold quality
esophagus	UBERON:0001043	59.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.55	gold quality
minor salivary gland	UBERON:0001830	51.92	gold quality
lower esophagus mucosa	UBERON:0035834	51.44	gold quality
upper leg skin	UBERON:0004262	51.41	gold quality
monocyte	CL:0000576	51.24	gold quality
muscle of leg	UBERON:0001383	51.18	gold quality
gastrocnemius	UBERON:0001388	50.72	gold quality
gall bladder	UBERON:0002110	50.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	48.85	gold quality
saliva-secreting gland	UBERON:0001044	48.46	gold quality
mouth mucosa	UBERON:0003729	48.08	gold quality
biceps brachii	UBERON:0001507	47.55	gold quality
lateral globus pallidus	UBERON:0002476	47.17	gold quality
vermiform appendix	UBERON:0001154	46.85	gold quality
quadriceps femoris	UBERON:0001377	46.45	gold quality
vastus lateralis	UBERON:0001379	46.28	gold quality
calcaneal tendon	UBERON:0003701	46.21	silver quality
vagina	UBERON:0000996	45.66	gold quality
buccal mucosa cell	CL:0002336	45.05	gold quality
caecum	UBERON:0001153	44.82	silver quality
superior surface of tongue	UBERON:0007371	44.62	gold quality
cardia of stomach	UBERON:0001162	44.28	gold quality
liver	UBERON:0002107	44.06	gold quality
body of pancreas	UBERON:0001150	43.97	silver quality
anatomical system	UBERON:0000467	43.95	gold quality
thyroid gland	UBERON:0002046	43.88	gold quality
multicellular organism	UBERON:0000468	43.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.