DIO3OS

Summary

DIO3OS (DIO3 opposite strand upstream RNA, HGNC:20348) is a long non-coding RNA gene on chromosome 14q32.31.

The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).

Source: NCBI Gene 64150 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20348
Approved symbol	DIO3OS
Name	DIO3 opposite strand upstream RNA
Location	14q32.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00041, DIO3-AS1
Ensembl gene	ENSG00000258498
Ensembl biotype	lncRNA
OMIM	608523
Entrez	64150
RNAcentral	URS000075DF04 — lncRNA, 3454 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000553575, ENST00000553729, ENST00000554441, ENST00000554694, ENST00000554735, ENST00000555174, ENST00000555882, ENST00000556120, ENST00000556266, ENST00000557109, ENST00000557532, ENST00000557661, ENST00000687708, ENST00000688341, ENST00000691437, ENST00000693099, ENST00000700195, ENST00000700196, ENST00000700197, ENST00000700198, ENST00000700213, ENST00000700214, ENST00000700215, ENST00000700216, ENST00000700217, ENST00000700218, ENST00000700219, ENST00000700220, ENST00000700221, ENST00000700222, ENST00000700223, ENST00000700224, ENST00000700225, ENST00000700226, ENST00000700227, ENST00000726557, ENST00000726558, ENST00000726559, ENST00000726560, ENST00000726561, ENST00000726562, ENST00000726563, ENST00000726564, ENST00000726565, ENST00000726566, ENST00000726567, ENST00000726568, ENST00000726569, ENST00000726570, ENST00000726571, ENST00000726572, ENST00000726573, ENST00000726574, ENST00000726575, ENST00000726576, ENST00000726577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553575 — 3 exons

Exon	Start	End
ENSE00002520316	101555224	101555676
ENSE00004051235	101560252	101560357
ENSE00004051249	101552221	101552754

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 98.30.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2626 / max 57.7446, expressed in 350 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144962	1.2626	350

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right ovary	UBERON:0002118	98.30	gold quality
left ovary	UBERON:0002119	98.28	gold quality
endocervix	UBERON:0000458	98.05	gold quality
left uterine tube	UBERON:0001303	97.34	gold quality
body of uterus	UBERON:0009853	96.38	gold quality
ectocervix	UBERON:0012249	94.11	gold quality
right lung	UBERON:0002167	92.91	gold quality
mucosa of stomach	UBERON:0001199	92.84	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.29	gold quality
tibial nerve	UBERON:0001323	91.76	gold quality
lower esophagus mucosa	UBERON:0035834	91.70	gold quality
omental fat pad	UBERON:0010414	91.53	gold quality
peritoneum	UBERON:0002358	91.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	91.14	gold quality
adipose tissue of abdominal region	UBERON:0007808	90.57	gold quality
uterine cervix	UBERON:0000002	90.47	gold quality
vagina	UBERON:0000996	90.43	gold quality
ovary	UBERON:0000992	89.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	89.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.61	gold quality
transverse colon	UBERON:0001157	89.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.03	gold quality
lower esophagus	UBERON:0013473	89.02	gold quality
right uterine tube	UBERON:0001302	88.94	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.33	gold quality
tibial artery	UBERON:0007610	87.70	gold quality
popliteal artery	UBERON:0002250	87.69	gold quality
upper lobe of left lung	UBERON:0008952	87.04	gold quality
prostate gland	UBERON:0002367	86.83	gold quality
gall bladder	UBERON:0002110	86.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• We analyzed the human DIO3 genomic region and identified a gene (DIO3OS) that is transcribed in the antisense orientation. (PMID:14962667)
• there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD. (PMID:29207070)
• The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA. (PMID:37271897)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.