DIRC1

Summary

DIRC1 (disrupted in renal carcinoma 1, HGNC:15760) is a long non-coding RNA gene on chromosome 2q32.2.

Disruption of DIRC1 by translocation is associated with familial clear cell renal cancer. Overexpression of DIRC1 is associated with tumor progression and poor prognosis in gastric cancer.

Source: NCBI Gene 116093 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15760
Approved symbol	DIRC1
Name	disrupted in renal carcinoma 1
Location	2q32.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000174325
Ensembl biotype	lncRNA
OMIM	606423
Entrez	116093
RNAcentral	URS0000E60A05 — lncRNA, 1473 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000649108

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000649108 — 2 exons

Exon	Start	End
ENSE00001178008	188789863	188790104
ENSE00001178019	188734155	188734949

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.96.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1231 / max 20.4381, expressed in 44 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
32828	0.1231	44

Top tissues by expression

181 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.96	gold quality
upper lobe of lung	UBERON:0008948	57.03	silver quality
lower lobe of lung	UBERON:0008949	56.48	silver quality
gall bladder	UBERON:0002110	53.81	gold quality
stromal cell of endometrium	CL:0002255	53.29	silver quality
smooth muscle tissue	UBERON:0001135	52.25	gold quality
right ovary	UBERON:0002118	51.12	gold quality
islet of Langerhans	UBERON:0000006	49.05	gold quality
calcaneal tendon	UBERON:0003701	48.68	silver quality
body of pancreas	UBERON:0001150	47.67	silver quality
monocyte	CL:0000576	47.21	silver quality
pancreas	UBERON:0001264	46.81	silver quality
left adrenal gland	UBERON:0001234	46.36	gold quality
ectocervix	UBERON:0012249	46.26	gold quality
vermiform appendix	UBERON:0001154	46.15	silver quality
myometrium	UBERON:0001296	45.62	gold quality
lung	UBERON:0002048	45.21	gold quality
lymph node	UBERON:0000029	45.03	gold quality
right lobe of liver	UBERON:0001114	44.98	silver quality
omental fat pad	UBERON:0010414	44.62	gold quality
peritoneum	UBERON:0002358	44.56	gold quality
subcutaneous adipose tissue	UBERON:0002190	44.33	gold quality
body of stomach	UBERON:0001161	44.05	gold quality
skin of leg	UBERON:0001511	43.95	gold quality
adipose tissue of abdominal region	UBERON:0007808	43.81	gold quality
caecum	UBERON:0001153	43.76	silver quality
endocervix	UBERON:0000458	43.68	gold quality
tibial artery	UBERON:0007610	43.65	gold quality
gastrocnemius	UBERON:0001388	43.49	silver quality
uterine cervix	UBERON:0000002	43.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study results showed that high expression of DIRC1 was found in gastric cancer (GC) tissues compared with normal gastric tissues. High expression of DIRC1 was associated with more cases of severer tumor malignancy and shorter overall survival; besides, high-level of DIRC1 was suggested to be an independent prognostic factor for GC. Knockdown of DIRC1 inhibited SGC-7901 GC cells proliferation, migration and invasion. (PMID:30575946)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.