DIRC3

Summary

DIRC3 (disrupted in renal carcinoma 3, HGNC:17805) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17805
Approved symbol	DIRC3
Name	disrupted in renal carcinoma 3
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ14199
Ensembl gene	ENSG00000231672
Ensembl biotype	lncRNA
OMIM	608262
Entrez	729582
RNAcentral	URS0000CCDF88 — lncRNA, 3910 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000423123, ENST00000474063, ENST00000484635, ENST00000486365, ENST00000654616, ENST00000663156, ENST00000663562, ENST00000671322, ENST00000675581, ENST00000676082, ENST00000676267, ENST00000717909, ENST00000744938, ENST00000744939, ENST00000832881

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423123 — 5 exons

Exon	Start	End
ENSE00001616462	217739487	217739575
ENSE00001688576	217713029	217713101
ENSE00001762211	217756021	217756147
ENSE00001779758	217703900	217704074
ENSE00004033684	217756468	217756555

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 80.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3570 / max 34.9655, expressed in 144 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33862	0.2170	104
33863	0.0478	31
33856	0.0378	17
33855	0.0374	9
33860	0.0119	1
33854	0.0050	1

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.40	gold quality
layer of synovial tissue	UBERON:0007616	76.59	gold quality
synovial joint	UBERON:0002217	76.48	gold quality
stromal cell of endometrium	CL:0002255	76.41	gold quality
right coronary artery	UBERON:0001625	75.79	gold quality
descending thoracic aorta	UBERON:0002345	75.72	gold quality
thoracic aorta	UBERON:0001515	75.32	gold quality
ascending aorta	UBERON:0001496	75.26	gold quality
popliteal artery	UBERON:0002250	75.10	gold quality
aorta	UBERON:0000947	75.07	gold quality
tibial artery	UBERON:0007610	75.07	gold quality
upper arm skin	UBERON:0004263	73.94	gold quality
right adrenal gland cortex	UBERON:0035827	73.67	gold quality
right adrenal gland	UBERON:0001233	72.32	gold quality
left coronary artery	UBERON:0001626	72.32	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.32	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.68	gold quality
coronary artery	UBERON:0001621	71.66	gold quality
left adrenal gland	UBERON:0001234	71.60	gold quality
smooth muscle tissue	UBERON:0001135	71.58	gold quality
lower esophagus	UBERON:0013473	71.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.51	gold quality
left adrenal gland cortex	UBERON:0035825	71.50	gold quality
mucosa of stomach	UBERON:0001199	71.15	gold quality
sural nerve	UBERON:0015488	71.01	gold quality
adrenal gland	UBERON:0002369	70.87	gold quality
adrenal cortex	UBERON:0001235	70.65	gold quality
right lobe of thyroid gland	UBERON:0001119	70.63	gold quality
ventricular zone	UBERON:0003053	70.54	gold quality
left uterine tube	UBERON:0001303	69.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• SNPs rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were associated with survival in laryngeal squamous cell carcinoma patients. (PMID:27793000)
• DIRC3 depletion in human melanoma cells leads to increased anchorage-independent growth, a hallmark of malignant transformation, whilst melanoma patients classified by low DIRC3 expression have decreased survival. These results suggest that DIRC3 may be a novel clinically important melanoma tumor suppressor gene. (PMID:31881017)
• lncRNA DIRC3 regulates invasiveness and insulin-like growth factor signaling in thyroid cancer cells. (PMID:37130273)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.