DISC1-IT1

Summary

DISC1-IT1 (DISC1 intronic transcript 1, HGNC:41325) is a long non-coding RNA gene on chromosome 1q42.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41325
Approved symbol	DISC1-IT1
Name	DISC1 intronic transcript 1
Location	1q42.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226758
Ensembl biotype	lncRNA
Entrez	104472714
RNAcentral	URS00007E4964 — lncRNA, 734 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456782

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456782 — 4 exons

Exon	Start	End
ENSE00001691196	231940928	231941050
ENSE00001707727	231943749	231943959
ENSE00001780707	231925834	231925950
ENSE00001786742	231944923	231945233

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 82.17.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0114 / max 9.9281, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9062	0.0114	2

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.94	gold quality
sural nerve	UBERON:0015488	77.48	gold quality
testis	UBERON:0000473	75.86	gold quality
bone marrow cell	CL:0002092	71.39	gold quality
bone marrow	UBERON:0002371	61.47	silver quality
muscle tissue	UBERON:0002385	61.28	silver quality
tonsil	UBERON:0002372	60.37	silver quality
liver	UBERON:0002107	57.06	silver quality
blood	UBERON:0000178	56.10	gold quality
placenta	UBERON:0001987	55.84	gold quality
urinary bladder	UBERON:0001255	55.39	gold quality
leukocyte	CL:0000738	55.32	gold quality
monocyte	CL:0000576	54.99	gold quality
prefrontal cortex	UBERON:0000451	53.17	gold quality
lymph node	UBERON:0000029	52.90	gold quality
uterine cervix	UBERON:0000002	51.46	silver quality
adrenal tissue	UBERON:0018303	51.31	silver quality
corpus callosum	UBERON:0002336	51.00	silver quality
prostate gland	UBERON:0002367	50.76	gold quality
gall bladder	UBERON:0002110	50.51	gold quality
calcaneal tendon	UBERON:0003701	50.21	silver quality
kidney	UBERON:0002113	49.91	gold quality
vermiform appendix	UBERON:0001154	49.29	gold quality
myometrium	UBERON:0001296	47.95	gold quality
hindlimb stylopod muscle	UBERON:0004252	47.94	silver quality
muscle of leg	UBERON:0001383	47.72	gold quality
adult mammalian kidney	UBERON:0000082	47.26	silver quality
frontal cortex	UBERON:0001870	47.19	gold quality
gastrocnemius	UBERON:0001388	47.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.