DISC1FP1

Summary

DISC1FP1 (DISC1 fusion partner 1, HGNC:33625) is a long non-coding RNA gene on chromosome 11q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33625
Approved symbol	DISC1FP1
Name	DISC1 fusion partner 1
Location	11q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	Boymaw
Ensembl gene	ENSG00000261645
Ensembl biotype	lncRNA
Entrez	101929222
RNAcentral	URS000075D64E — lncRNA, 774 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 lncRNA, 1 retained_intron

ENST00000561596, ENST00000562245, ENST00000562678, ENST00000563681, ENST00000569513, ENST00000649150, ENST00000670926, ENST00000745651, ENST00000745652, ENST00000745653, ENST00000745654, ENST00000745655, ENST00000745656

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000561596 — 7 exons

Exon	Start	End
ENSE00002580543	90844880	90844949
ENSE00002584018	90546754	90546895
ENSE00002588189	90863353	90863359
ENSE00002593834	90801766	90801862
ENSE00002618125	90602805	90602908
ENSE00002627466	90852616	90852707
ENSE00002629244	90251285	90251317

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 82.20.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1266 / max 91.9757, expressed in 375 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
116172	0.5656	176
116170	0.5134	185
116182	0.0254	6
116181	0.0222	4

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.20	gold quality
bone marrow cell	CL:0002092	71.09	silver quality
sural nerve	UBERON:0015488	67.50	gold quality
bone marrow	UBERON:0002371	66.67	silver quality
cortical plate	UBERON:0005343	65.00	gold quality
ganglionic eminence	UBERON:0004023	62.58	gold quality
calcaneal tendon	UBERON:0003701	61.00	gold quality
muscle tissue	UBERON:0002385	60.32	gold quality
urinary bladder	UBERON:0001255	59.97	gold quality
placenta	UBERON:0001987	59.29	gold quality
skeletal muscle tissue	UBERON:0001134	58.49	gold quality
endometrium	UBERON:0001295	57.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.49	gold quality
liver	UBERON:0002107	56.20	gold quality
monocyte	CL:0000576	56.16	gold quality
lymph node	UBERON:0000029	55.59	gold quality
smooth muscle tissue	UBERON:0001135	54.01	gold quality
primary visual cortex	UBERON:0002436	53.57	gold quality
vermiform appendix	UBERON:0001154	53.37	gold quality
blood	UBERON:0000178	53.32	gold quality
prefrontal cortex	UBERON:0000451	52.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.49	gold quality
tonsil	UBERON:0002372	52.48	gold quality
islet of Langerhans	UBERON:0000006	52.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	51.97	gold quality
right lobe of liver	UBERON:0001114	51.80	gold quality
muscle of leg	UBERON:0001383	51.80	gold quality
right coronary artery	UBERON:0001625	51.60	gold quality
adipose tissue	UBERON:0001013	51.42	gold quality
gall bladder	UBERON:0002110	51.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Expression of the DB7 fusion gene may reduce protein translation to impair brain functions and thereby contribute to the pathogenesis of major psychiatric disorders. (PMID:24908665)
• Boymaw gene could potentially be a susceptibility gene for major psychiatric disorders in both the Scottish t(1,11) family and the general population of patients. (PMID:25943690)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.