DISC2

Summary

DISC2 (disrupted in schizophrenia 2, HGNC:2889) is a long non-coding RNA gene on chromosome 1q42.1.

DISC2 is thought to specify a noncoding RNA molecule antisense to DISC1 (MIM 605210). Both genes were found to be disrupted by a translocation in a large schizophrenia (MIM 181500) kindred.

Source: NCBI Gene 27184 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 3 total
• Phenotypes (HPO): 7

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2889
Approved symbol	DISC2
Name	disrupted in schizophrenia 2
Location	1q42.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	DISC1-AS1, DISC1OS, NCRNA00015
OMIM	606271
Entrez	27184
RNAcentral	URS000075F11A — lncRNA, 3892 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The potential involvement of DISC2 in the pathogenesis of psychiatric illness is discussed [review]. (PMID:17912248)
• that the transcript levels of DISC1 and DISC2 long non-coding RNAs could be considered as a good putative biomarker for individuals with bipolar disorder (PMID:30599263)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000253923 (1:231814957 A>G), RS1000874564 (1:231820005 A>G,T), RS1002207014 (1:231814192 G>T), RS1002540690 (1:231815923 G>A), RS1002841142 (1:231818081 C>A,T), RS1003433268 (1:231816844 T>C), RS1003880865 (1:231818466 G>A,T), RS1004152243 (1:231819884 G>T), RS1004435363 (1:231818756 C>A,T), RS1005594687 (1:231814950 A>G), RS1005888414 (1:231815465 G>A), RS1006087371 (1:231816326 C>T), RS1007102319 (1:231815430 C>G), RS1007445066 (1:231814167 C>T), RS1007445348 (1:231817123 T>C)

Disease associations

OMIM: gene MIM:606271 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

7 total (7 of 7 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0000738	Hallucinations
HP:0000746	Delusion
HP:0002353	EEG abnormality
HP:0007086	Social and occupational deterioration
HP:0100753	Schizophrenia
HP:0410291	Negativism

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST000635_12	Response to statin therapy	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.