DLEU1-AS1

Summary

DLEU1-AS1 (DLEU1 antisense RNA 1, HGNC:50496) is a long non-coding RNA gene on chromosome 13q14.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50496
Approved symbol	DLEU1-AS1
Name	DLEU1 antisense RNA 1
Location	13q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01308
Entrez	103689915
RNAcentral	URS000032D03F — lncRNA, 731 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• mechanistic experiments uncovered that DLEU1 could recruit LSD1 (lysine specific demethylase 1) to the promoter regions of KLF2 and then suppressed its transcription. In addition, rescue assays revealed that the oncogenic function mediated by DLEU1 in GC was partly by regulating KLF2. (PMID:29282356)
• LINC01308 accelerates the malignant progression of ovarian cancer by binding to miRNA-506. (PMID:31081077)
• Long non-coding RNA deleted in lymphocytic leukaemia 1 promotes hepatocellular carcinoma progression by sponging miR-133a to regulate IGF-1R expression. (PMID:31207081)
• Upregulation of Serum lncRNA DLEU1 Predicts Progression of Premalignant Endometrial Lesion and Unfavorable Clinical Outcome of Endometrial Cancer. (PMID:33327893)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000289784 (13:50526942 T>G), RS1000503169 (13:50520983 C>G), RS1000875393 (13:50520662 G>A,C), RS1001783507 (13:50526891 C>G), RS1002212445 (13:50525600 C>A,G), RS1002761572 (13:50525390 G>A), RS1003247459 (13:50525549 C>A), RS1004220488 (13:50523872 G>T), RS1004244154 (13:50527638 T>C), RS1004422242 (13:50521784 C>T), RS1004615829 (13:50527439 T>A), RS1005079327 (13:50525618 C>T), RS1005713959 (13:50523381 T>C), RS1006137099 (13:50525096 C>A,T), RS1006525131 (13:50527456 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.