DLEU2

Summary

DLEU2 (deleted in lymphocytic leukemia 2, HGNC:13748) is a long non-coding RNA gene on chromosome 13q14.2.

This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1.

Source: NCBI Gene 8847 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13748
Approved symbol	DLEU2
Name	deleted in lymphocytic leukemia 2
Location	13q14.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LEU2, TRIM13OS, NCRNA00022, LINC00022, MIR15AHG
Ensembl gene	ENSG00000231607
Ensembl biotype	lncRNA
OMIM	605766
Entrez	8847
RNAcentral	URS0000EF28B1 — lncRNA, 3166 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 128 — 128 lncRNA

ENST00000421758, ENST00000425586, ENST00000433070, ENST00000443587, ENST00000449579, ENST00000458725, ENST00000621282, ENST00000651713, ENST00000656688, ENST00000658343, ENST00000659339, ENST00000661799, ENST00000662092, ENST00000665220, ENST00000666359, ENST00000668133, ENST00000668305, ENST00000686700, ENST00000686946, ENST00000688690, ENST00000690259, ENST00000691340, ENST00000692504, ENST00000700817, ENST00000700934, ENST00000701027, ENST00000701047, ENST00000701101, ENST00000701174, ENST00000732461, ENST00000732462, ENST00000732463, ENST00000732464, ENST00000732465, ENST00000732466, ENST00000732467, ENST00000732468, ENST00000732469, ENST00000732470, ENST00000732471, ENST00000732472, ENST00000732473, ENST00000732474, ENST00000732475, ENST00000732476, ENST00000732477, ENST00000732478, ENST00000732479, ENST00000732480, ENST00000732481, ENST00000732482, ENST00000732483, ENST00000732484, ENST00000732485, ENST00000732486, ENST00000732487, ENST00000732488, ENST00000732489, ENST00000732490, ENST00000732491, ENST00000732492, ENST00000732493, ENST00000732494, ENST00000732495, ENST00000732496, ENST00000732497, ENST00000732498, ENST00000732499, ENST00000732500, ENST00000732501, ENST00000732502, ENST00000732503, ENST00000732504, ENST00000732505, ENST00000732506, ENST00000732507, ENST00000732508, ENST00000732509, ENST00000732510, ENST00000732511, ENST00000732512, ENST00000732513, ENST00000732514, ENST00000732515, ENST00000732516, ENST00000732517, ENST00000732518, ENST00000732519, ENST00000732520, ENST00000732521, ENST00000732522, ENST00000732523, ENST00000732524, ENST00000732525, ENST00000732526, ENST00000732527, ENST00000732528, ENST00000732529, ENST00000732530, ENST00000732531, ENST00000732532, ENST00000732533, ENST00000732534, ENST00000732535, ENST00000732536, ENST00000732537, ENST00000732538, ENST00000732539, ENST00000732540, ENST00000732541, ENST00000732542, ENST00000732543, ENST00000732544, ENST00000732545, ENST00000732546, ENST00000732547, ENST00000732548, ENST00000732549, ENST00000732550, ENST00000732551, ENST00000732552, ENST00000732553, ENST00000732554, ENST00000732557, ENST00000732558, ENST00000732559, ENST00000732560, ENST00000732561

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421758 — 3 exons

Exon	Start	End
ENSE00001700560	50068097	50068163
ENSE00004062906	50081823	50082101
ENSE00004062960	50049184	50049662

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 92.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.0939 / max 361.4076, expressed in 1792 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137353	12.0545	1580
137345	6.6219	1413
137351	0.6468	283
137350	0.5455	236
137352	0.4702	212
137338	0.4188	196
137344	0.3362	150

Top tissues by expression

263 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	92.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.51	gold quality
bone marrow cell	CL:0002092	89.48	gold quality
monocyte	CL:0000576	89.14	gold quality
adrenal tissue	UBERON:0018303	89.06	gold quality
ganglionic eminence	UBERON:0004023	88.57	gold quality
leukocyte	CL:0000738	88.39	gold quality
sural nerve	UBERON:0015488	88.20	gold quality
ventricular zone	UBERON:0003053	87.68	gold quality
granulocyte	CL:0000094	84.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.87	gold quality
colonic epithelium	UBERON:0000397	81.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.39	gold quality
spleen	UBERON:0002106	80.96	gold quality
adenohypophysis	UBERON:0002196	80.68	gold quality
left testis	UBERON:0004533	80.44	gold quality
descending thoracic aorta	UBERON:0002345	80.41	gold quality
right testis	UBERON:0004534	80.30	gold quality
popliteal artery	UBERON:0002250	80.27	gold quality
tibial artery	UBERON:0007610	80.24	gold quality
tibial nerve	UBERON:0001323	80.12	gold quality
right lobe of liver	UBERON:0001114	79.96	gold quality
cerebellar hemisphere	UBERON:0002245	79.88	gold quality
aorta	UBERON:0000947	79.82	gold quality
thoracic aorta	UBERON:0001515	79.77	gold quality
ascending aorta	UBERON:0001496	79.76	gold quality
cerebellar cortex	UBERON:0002129	79.61	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.43	gold quality
right coronary artery	UBERON:0001625	79.35	gold quality
mucosa of transverse colon	UBERON:0004991	79.29	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	11.25
E-CURD-119	yes	4.49
E-ANND-3	yes	4.01
E-MTAB-11268	no	1489.54

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYB, MYC, PAX5

Literature-anchored findings (GeneRIF, showing 30)

• propose that the underlying pathomechanism of CLL involves co-regulation of miRNA genes miR-16-1 and miR-15a by the two long non-coding RNA genes DLEU1 and DLEU2. (PMID:19347735)
• Inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of microRNA. (PMID:19591824)
• we describe an example where two lncRNA genes (DLEU1 and DLEU2) are epigenetically deregulated together with a cluster of neighboring protein-coding tumor suppressor genes in almost all patients suffering from chronic lymphocytic leukemia (PMID:23593011)
• BSAP directly interacts with the Dleu2 promoter. (PMID:23995789)
• The DLEU2 locus and embedded miRNA cluster miR-15a/16-1 is commonly deleted in adult cancers and shown to induce leukemogenesis, however in pediatric AML this region is found transcriptionally repressed. (PMID:24885794)
• Knocking-down of deleted in lymphocytic leukemia 2 (DLEU2) or its target gene ACE2 could efficiently decrease the expression of cyclin D1 via the enhanced ubiquitination and degradation. (PMID:28977802)
• LncRNA Dleu2 influences the proliferation, migration, and invasion of laryngeal cancer cells through miR-16-1. (PMID:29687850)
• circRNA-DLEU2 was upregulated in acute myeloid leukemia (AML) tissues and cells, which promoted AML cell proliferation and inhibited cell apoptosis. Collectively, circRNA-DLEU2 accelerated AML by suppressing miR-496 and promoting PRKACB expression. (PMID:30037980)
• Findings showed that upregulation of DLEU2 was a frequent occurrence in pancreatic cancer (PC) tissues, and DLEU2 dramatically promoted the proliferation and invasion of PC cells in vitro. These results suggest that DLEU2 plays a crucial role in the growth and invasiveness potential of PC. (PMID:30838724)
• Based on these findings, we infer that DLEU2 exon 9 expression might serve as a valuable biomarker of unfavorable overall survival in esophageal adenocarcinoma patients. (PMID:30849637)
• LncRNA DLEU2 accelerates the tumorigenesis and invasion of non-small cell lung cancer by sponging miR-30a-5p. (PMID:31721438)
• Long non-coding RNA DLEU2 promotes the progression of esophageal cancer through miR-30e-5p/E2F7 axis. (PMID:31884338)
• LncRNA DLEU2 promotes tumour growth by sponging miR-337-3p in human osteosarcoma. (PMID:32196715)
• Long noncoding RNA DLEU2 predicts a poor prognosis and enhances malignant properties in laryngeal squamous cell carcinoma through the miR-30c-5p/PIK3CD/Akt axis. (PMID:32555190)
• DLEU2: A Meaningful Long Noncoding RNA in Oncogenesis. (PMID:33106136)
• lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration. (PMID:33221762)
• LncRNA DLEU2 promotes cervical cancer cell proliferation by regulating cell cycle and NOTCH pathway. (PMID:33675808)
• Knockdown of long noncoding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA3693p/TRIM2 axis. (PMID:33760118)
• LncRNA DLEU2 is activated by STAT1 and induces gastric cancer development via targeting miR-23b-3p/NOTCH2 axis and Notch signaling pathway. (PMID:33785336)
• RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma. (PMID:34544449)
• E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1. (PMID:35075115)
• LINC00022 acts as an oncogene in colorectal cancer progression via sponging miR-375-3p to regulate FOXF1 expression. (PMID:35468741)
• Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells. (PMID:35611845)
• LncRNA DLEU2 silencing impedes the migration, invasion and EMT in gastric cancer cell by suppressing PI3K/AKT signaling pathway. (PMID:35736813)
• DLEU2 modulates proliferation, migration and invasion of platelet-derived growth factor-BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs) via miR-212-5p/YWHAZ axis. (PMID:35775826)
• Long noncoding RNA DLEU2 regulates the progression of Wilm’s tumor via miR-539-3p/HOXB2 axis. (PMID:36209036)
• lncRNA DLEU2 Accelerates Oral Cancer Progression via miR-30a-5p/RAP1B Axis to Regulate p38 MAPK Signaling Pathway. (PMID:36277988)
• Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer. (PMID:37095423)
• LncRNA DLEU2 contributes to Taxol resistance of gastric cancer cells through regulating the miR-30c-5p-LDHA axis. (PMID:37161284)
• DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells. (PMID:38305289)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.