DLEU7-AS1

Summary

DLEU7-AS1 (DLEU7 antisense RNA 1, HGNC:39966) is a long non-coding RNA gene on chromosome 13q14.3.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 4 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39966
Approved symbol	DLEU7-AS1
Name	DLEU7 antisense RNA 1
Location	13q14.3
Locus type	RNA, long non-coding
Status	Approved
Entrez	100874074
RNAcentral	URS000075D421 — lncRNA, 1824 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Reduced expression of lncRNA DLEU7-AS1 is a novel favorable prognostic factor in acute myeloid leukemia. (PMID:35506368)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000074150 (13:50821492 G>A), RS1000103001 (13:50820935 A>C,T), RS1000145862 (13:50821739 AAAC>A), RS1000399717 (13:50808400 A>C), RS1000483843 (13:50823316 A>G), RS1000588303 (13:50848409 A>G), RS1000591768 (13:50829255 G>A), RS1000638347 (13:50816672 C>T), RS1000691398 (13:50847926 C>T), RS1000700075 (13:50843062 G>T), RS1000772508 (13:50810260 C>T), RS1000904825 (13:50841926 T>C), RS1000953623 (13:50816170 C>A), RS1001058124 (13:50842209 T>C), RS1001113198 (13:50822445 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST004611_194	High light scatter reticulocyte count	1.000000e-12
GCST004612_128	High light scatter reticulocyte percentage of red cells	1.000000e-13
GCST004619_5	Reticulocyte fraction of red cells	3.000000e-11
GCST004622_125	Reticulocyte count	1.000000e-09
GCST007052_9	Lipoprotein (a) levels	4.000000e-07
GCST90002383_23	Hematocrit	5.000000e-11
GCST90002384_326	Hemoglobin	6.000000e-10
GCST90002385_15	High light scatter reticulocyte count	2.000000e-21
GCST90002386_157	High light scatter reticulocyte percentage of red cells	6.000000e-25
GCST90002387_135	Immature fraction of reticulocytes	3.000000e-14
GCST90002405_256	Reticulocyte count	1.000000e-17
GCST90002406_410	Reticulocyte fraction of red cells	5.000000e-22

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0006925	lipoprotein A measurement
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.