DLG1-AS1

Summary

DLG1-AS1 (DLG1 antisense RNA 1, HGNC:44154) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44154
Approved symbol	DLG1-AS1
Name	DLG1 antisense RNA 1
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227375
Ensembl biotype	lncRNA
Entrez	100507086
RNAcentral	URS000075D81A — lncRNA, 1703 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000414529, ENST00000430666, ENST00000653937, ENST00000656096, ENST00000657499, ENST00000824288, ENST00000824289

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414529 — 3 exons

Exon	Start	End
ENSE00001644624	197298252	197298381
ENSE00001688784	197298978	197299092
ENSE00001702640	197302528	197302781

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 82.77.

Top tissues by expression

211 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	82.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.41	gold quality
buccal mucosa cell	CL:0002336	72.29	gold quality
left testis	UBERON:0004533	71.06	gold quality
right testis	UBERON:0004534	69.66	gold quality
testis	UBERON:0000473	68.76	gold quality
sural nerve	UBERON:0015488	63.85	gold quality
ventricular zone	UBERON:0003053	60.98	gold quality
mucosa of transverse colon	UBERON:0004991	59.65	gold quality
islet of Langerhans	UBERON:0000006	56.76	gold quality
ganglionic eminence	UBERON:0004023	56.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.52	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.11	silver quality
rectum	UBERON:0001052	53.67	gold quality
right lobe of thyroid gland	UBERON:0001119	53.04	gold quality
pancreas	UBERON:0001264	52.77	gold quality
monocyte	CL:0000576	52.10	gold quality
thyroid gland	UBERON:0002046	51.87	gold quality
esophagus mucosa	UBERON:0002469	51.86	gold quality
left lobe of thyroid gland	UBERON:0001120	51.22	gold quality
esophagus	UBERON:0001043	51.18	gold quality
adult organism	UBERON:0007023	50.52	silver quality
prefrontal cortex	UBERON:0000451	49.19	gold quality
adult mammalian kidney	UBERON:0000082	49.12	gold quality
muscle of leg	UBERON:0001383	48.75	gold quality
transverse colon	UBERON:0001157	48.63	gold quality
gastrocnemius	UBERON:0001388	48.42	gold quality
cortex of kidney	UBERON:0001225	48.11	gold quality
metanephros cortex	UBERON:0010533	47.85	gold quality
nasal cavity mucosa	UBERON:0001826	47.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• DLG1-AS1 eliminated the inhibition of miR-107 on the expression of its target gene ZHX1 by competitively binding to miR-107. (PMID:30231238)
• High DLG1-AS1 expression is associated with papillary thyroid carcinoma. (PMID:31718630)
• The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression. (PMID:33197895)
• lncRNA DLG1-AS1 promotes cervical cancer cell gemcitabine resistance by regulating miR-16-5p/HDGF. (PMID:35388952)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.