DLG5-AS1

Summary

DLG5-AS1 (DLG5 antisense RNA 1, HGNC:45109) is a long non-coding RNA gene on chromosome 10q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45109
Approved symbol	DLG5-AS1
Name	DLG5 antisense RNA 1
Location	10q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233871
Ensembl biotype	lncRNA
Entrez	100128292
RNAcentral	URS0000759D71 — lncRNA, 3031 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 17 lncRNA, 1 retained_intron

ENST00000449852, ENST00000632919, ENST00000842780, ENST00000842781, ENST00000842782, ENST00000842783, ENST00000842784, ENST00000842785, ENST00000842786, ENST00000842787, ENST00000842788, ENST00000842789, ENST00000842790, ENST00000842791, ENST00000842792, ENST00000842793, ENST00000842794, ENST00000842795

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000449852 — 2 exons

Exon	Start	End
ENSE00004268194	77927173	77927622
ENSE00004268215	77929589	77929832

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 78.95.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	78.95	gold quality
adenohypophysis	UBERON:0002196	78.94	gold quality
pituitary gland	UBERON:0000007	77.66	gold quality
left adrenal gland cortex	UBERON:0035825	76.96	gold quality
left adrenal gland	UBERON:0001234	76.28	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.14	gold quality
right uterine tube	UBERON:0001302	76.03	gold quality
right adrenal gland cortex	UBERON:0035827	75.98	gold quality
right adrenal gland	UBERON:0001233	75.79	gold quality
ventricular zone	UBERON:0003053	75.06	gold quality
cortical plate	UBERON:0005343	75.01	gold quality
adrenal gland	UBERON:0002369	74.49	gold quality
gastrocnemius	UBERON:0001388	72.99	gold quality
muscle of leg	UBERON:0001383	72.07	gold quality
skeletal muscle tissue	UBERON:0001134	71.92	gold quality
muscle tissue	UBERON:0002385	71.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.10	gold quality
lower esophagus	UBERON:0013473	71.02	gold quality
hypothalamus	UBERON:0001898	70.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.37	gold quality
Ammon’s horn	UBERON:0001954	70.20	gold quality
fallopian tube	UBERON:0003889	70.03	gold quality
ovary	UBERON:0000992	69.93	gold quality
right ovary	UBERON:0002118	69.89	gold quality
left ovary	UBERON:0002119	69.85	gold quality
anterior cingulate cortex	UBERON:0009835	69.84	gold quality
prefrontal cortex	UBERON:0000451	69.79	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.71	gold quality
cerebral cortex	UBERON:0000956	69.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA DLG5-AS1 facilitates breast cancer cell proliferation and invasion by promoting EZH2-mediated transcriptional silencing of SFRP1. (PMID:38677505)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.