DLGAP1-AS1

Summary

DLGAP1-AS1 (DLGAP1 antisense RNA 1, HGNC:31676) is a long non-coding RNA gene on chromosome 18p11.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31676
Approved symbol	DLGAP1-AS1
Name	DLGAP1 antisense RNA 1
Location	18p11.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	HsT914, FLJ35776
Ensembl gene	ENSG00000177337
Ensembl biotype	lncRNA
Entrez	649446
RNAcentral	URS000075ADDB — lncRNA, 1023 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000317114, ENST00000573355, ENST00000574411, ENST00000575606, ENST00000576606, ENST00000577995, ENST00000669270, ENST00000700825, ENST00000701468

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000317114 — 3 exons

Exon	Start	End
ENSE00001217545	3594420	3594484
ENSE00003982715	3594099	3594240
ENSE00003982716	3596579	3598352

Expression profiles

Bgee: expression breadth ubiquitous, 216 present calls, max score 90.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.2600 / max 221.5998, expressed in 1789 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169199	9.1881	1715
169203	6.0247	1581
169200	2.0533	975
169202	1.2427	701
169201	0.7512	341

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right adrenal gland cortex	UBERON:0035827	90.37	gold quality
right adrenal gland	UBERON:0001233	90.33	gold quality
oviduct epithelium	UBERON:0004804	90.04	gold quality
left ventricle myocardium	UBERON:0006566	89.96	gold quality
left adrenal gland	UBERON:0001234	89.67	gold quality
left adrenal gland cortex	UBERON:0035825	89.63	gold quality
tendon of biceps brachii	UBERON:0008188	89.28	gold quality
cardiac muscle of right atrium	UBERON:0003379	89.00	gold quality
adrenal cortex	UBERON:0001235	88.74	gold quality
corpus epididymis	UBERON:0004359	88.69	gold quality
buccal mucosa cell	CL:0002336	87.88	gold quality
adrenal gland	UBERON:0002369	87.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.79	gold quality
myocardium	UBERON:0002349	86.56	gold quality
cauda epididymis	UBERON:0004360	84.61	gold quality
apex of heart	UBERON:0002098	84.01	gold quality
right atrium auricular region	UBERON:0006631	83.79	gold quality
cardiac atrium	UBERON:0002081	83.69	gold quality
heart left ventricle	UBERON:0002084	83.47	gold quality
kidney epithelium	UBERON:0004819	83.32	silver quality
cardiac ventricle	UBERON:0002082	83.13	gold quality
heart	UBERON:0000948	82.61	gold quality
right coronary artery	UBERON:0001625	82.16	gold quality
sural nerve	UBERON:0015488	82.16	gold quality
tendon	UBERON:0000043	82.12	gold quality
vermiform appendix	UBERON:0001154	81.68	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.65	gold quality
prostate gland	UBERON:0002367	81.62	gold quality
adenohypophysis	UBERON:0002196	81.29	gold quality
caput epididymis	UBERON:0004358	81.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Long noncoding RNA DLGAP1-AS1 promotes cell proliferation in hepatocellular carcinoma via sequestering miR-486-5p. (PMID:31633236)
• Long non-coding RNA DLGAP1-AS1 facilitates tumorigenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via the feedback loop of miR-26a/b-5p/IL-6/JAK2/STAT3 and Wnt/beta-catenin pathway. (PMID:31949128)
• Long noncoding RNA DLGAP1-AS1 promotes the progression of glioma by regulating the miR-1297/EZH2 axis. (PMID:33901010)
• Long non-coding RNA DLGAP1-AS1 promotes the progression of gastric cancer via miR-515-5p/MARK4 axis. (PMID:34037089)
• LncRNA DLGAP1-AS1 accelerates glioblastoma cell proliferation through targeting miR-515-5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway. (PMID:34536977)
• Long non-coding RNA DLGAP1 antisense RNA 1 accelerates glioma progression via the microRNA-628-5p/DEAD-box helicase 59 pathway. (PMID:35113786)
• In Silico Analysis Identifies Upregulated lncRNA DLGAP1-AS1 Which Is Correlated to Poor Prognosis and Promotes Cell Proliferation in Glioblastoma. (PMID:35341001)
• Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel Oncogenes in Multiple Cancers. (PMID:36121088)
• Long non-coding RNA DLGAP1-AS1 modulates the development of non-small-cell lung cancer via the microRNA-193a-5p/DTL axis. (PMID:36183046)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.