DLGAP1-AS2

Summary

DLGAP1-AS2 (DLGAP1 antisense RNA 2, HGNC:28146) is a long non-coding RNA gene on chromosome 18p11.31.

Biomarker of hepatocellular carcinoma.

Source: NCBI Gene 84777 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28146
Approved symbol	DLGAP1-AS2
Name	DLGAP1 antisense RNA 2
Location	18p11.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC11082
Ensembl gene	ENSG00000262001
Ensembl biotype	lncRNA
Entrez	84777
RNAcentral	URS000075EE3F — lncRNA, 923 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000572856, ENST00000573177, ENST00000687483, ENST00000689896, ENST00000691824, ENST00000692104, ENST00000693339, ENST00000715378, ENST00000715379, ENST00000715380, ENST00000715381

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000572856 — 2 exons

Exon	Start	End
ENSE00002642757	3606554	3608336
ENSE00002654065	3603738	3604215

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 85.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.1459 / max 360.7937, expressed in 1287 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169209	4.1912	819
169207	1.4729	482
169212	1.1436	177
169214	0.5966	192
169210	0.5639	186
169216	0.4767	209
169208	0.4112	120
169211	0.3486	173
169217	0.3249	56
169213	0.2790	117

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.07	gold quality
cardiac muscle of right atrium	UBERON:0003379	79.67	gold quality
left ventricle myocardium	UBERON:0006566	79.62	gold quality
right adrenal gland cortex	UBERON:0035827	78.33	gold quality
left adrenal gland	UBERON:0001234	77.83	gold quality
left adrenal gland cortex	UBERON:0035825	77.70	gold quality
adenohypophysis	UBERON:0002196	77.36	gold quality
right adrenal gland	UBERON:0001233	77.16	gold quality
stromal cell of endometrium	CL:0002255	75.98	gold quality
adrenal cortex	UBERON:0001235	75.76	gold quality
adrenal gland	UBERON:0002369	75.67	gold quality
metanephros cortex	UBERON:0010533	75.66	gold quality
sural nerve	UBERON:0015488	75.46	gold quality
left ovary	UBERON:0002119	75.38	gold quality
right uterine tube	UBERON:0001302	75.17	gold quality
calcaneal tendon	UBERON:0003701	74.77	gold quality
endocervix	UBERON:0000458	74.75	gold quality
pituitary gland	UBERON:0000007	74.49	gold quality
mucosa of transverse colon	UBERON:0004991	74.47	gold quality
tibial nerve	UBERON:0001323	74.41	gold quality
rectum	UBERON:0001052	74.25	gold quality
epithelial cell of pancreas	CL:0000083	73.65	gold quality
granulocyte	CL:0000094	73.43	gold quality
body of uterus	UBERON:0009853	73.40	gold quality
spleen	UBERON:0002106	73.26	gold quality
right ovary	UBERON:0002118	73.14	gold quality
ventricular zone	UBERON:0003053	72.30	gold quality
left uterine tube	UBERON:0001303	72.25	gold quality
adrenal tissue	UBERON:0018303	72.20	gold quality
bone marrow cell	CL:0002092	71.69	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.02

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• lncRNA DLGAP1-AS2 Knockdown Inhibits Hepatocellular Carcinoma Cell Migration and Invasion by Regulating miR-154-5p Methylation. (PMID:33195697)
• The long noncoding RNA DLGAP1-AS2 facilitates cholangiocarcinoma progression via miR-505 and GALNT10. (PMID:33301605)
• LncRNA DLGAP1-AS2 regulates miR-503/cyclin D1 to promote cell proliferation in non-small cell lung cancer. (PMID:34454450)
• LncRNA DLGAP1-AS2 overexpression associates with gastric tumorigenesis: a promising diagnostic and therapeutic target. (PMID:34981339)
• METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m[6]A/c-Myc-dependent aerobic glycolysis. (PMID:35972892)
• Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel Oncogenes in Multiple Cancers. (PMID:36121088)
• DLGAP1-AS2 promotes human colorectal cancer progression through trans-activation of Myc. (PMID:36222892)
• Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer. (PMID:36376892)
• The knockdown of lncRNA DLGAP1-AS2 suppresses osteosarcoma progression by inhibiting aerobic glycolysis via the miR-451a/HK2 axis. (PMID:37817462)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.