DM1-AS

Summary

DM1-AS (DM1 locus antisense RNA, HGNC:53125) is a long non-coding RNA gene on chromosome 19q13.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53125
Approved symbol	DM1-AS
Name	DM1 locus antisense RNA
Location	19q13.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267395
Ensembl biotype	lncRNA
Entrez	109729182
RNAcentral	URS00007671C2 — lncRNA, 730 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000586251, ENST00000586498, ENST00000590076, ENST00000591530, ENST00000723044, ENST00000723045

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000586251 — 3 exons

Exon	Start	End
ENSE00002784527	45772306	45772504
ENSE00002815589	45771490	45771675
ENSE00002843455	45770982	45771079

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 96.88.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4163 / max 16.1639, expressed in 236 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176506	0.4163	236

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	96.88	gold quality
left ovary	UBERON:0002119	89.31	gold quality
right lobe of thyroid gland	UBERON:0001119	88.81	gold quality
right ovary	UBERON:0002118	88.12	gold quality
left lobe of thyroid gland	UBERON:0001120	87.78	gold quality
body of pancreas	UBERON:0001150	87.39	gold quality
thyroid gland	UBERON:0002046	86.21	gold quality
body of stomach	UBERON:0001161	86.09	gold quality
left uterine tube	UBERON:0001303	86.02	gold quality
body of uterus	UBERON:0009853	86.01	gold quality
endocervix	UBERON:0000458	85.79	gold quality
sural nerve	UBERON:0015488	85.63	gold quality
adenohypophysis	UBERON:0002196	84.99	gold quality
right lobe of liver	UBERON:0001114	84.49	gold quality
tibial nerve	UBERON:0001323	84.31	gold quality
mucosa of stomach	UBERON:0001199	83.96	gold quality
ectocervix	UBERON:0012249	83.11	gold quality
right coronary artery	UBERON:0001625	83.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	83.09	gold quality
pituitary gland	UBERON:0000007	83.07	gold quality
stomach	UBERON:0000945	82.21	gold quality
left coronary artery	UBERON:0001626	82.15	gold quality
descending thoracic aorta	UBERON:0002345	81.89	gold quality
lower esophagus	UBERON:0013473	81.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.88	gold quality
ascending aorta	UBERON:0001496	81.82	gold quality
right adrenal gland	UBERON:0001233	81.81	gold quality
thoracic aorta	UBERON:0001515	81.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	81.67	gold quality
lower esophagus mucosa	UBERON:0035834	81.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data provide evidence that DM1-AS transcripts are widely expressed as low abundant RNAs and propose they belong to the class of lncRNAs. They undergo alternative splicing, whereby the (CAG)n segment is removed as part of an intron. Thus, in myotonic dystrophy 1, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced. DM1-AS expression appears upregulated in patients, but transcript remains very low. (PMID:28102759)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.