DMBX1

Summary

DMBX1 (diencephalon/mesencephalon homeobox 1, HGNC:19026) is a protein-coding gene on chromosome 1p33, encoding Diencephalon/mesencephalon homeobox protein 1 (Q8NFW5). Functions as a transcriptional repressor.

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene.

Source: NCBI Gene 127343 — RefSeq curated summary.

At a glance

• Gene–disease (curated): complex neurodevelopmental disorder (Limited, GenCC)
• GWAS associations: 4
• Clinical variants (ClinVar): 64 total — 1 likely-pathogenic
• MANE Select transcript: NM_172225

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19026
Approved symbol	DMBX1
Name	diencephalon/mesencephalon homeobox 1
Location	1p33
Locus type	gene with protein product
Status	Approved
Aliases	PAXB, MBX, Atx
Ensembl gene	ENSG00000197587
Ensembl biotype	protein_coding
OMIM	607410
Entrez	127343

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000360032, ENST00000928354, ENST00000928355

RefSeq mRNA: 4 — MANE Select: NM_172225 NM_001387775, NM_001387776, NM_147192, NM_172225

CCDS: CCDS536

Canonical transcript exons

ENST00000360032 — 6 exons

Exon	Start	End
ENSE00000839541	46510935	46511283
ENSE00000839542	46510476	46510654
ENSE00001214126	46512043	46516216
ENSE00001214136	46506999	46507164
ENSE00003897772	46489836	46489877
ENSE00003898020	46490644	46490783

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 75.52.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7997 / max 180.2293, expressed in 264 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2747	0.5872	234
2746	0.2064	106
2748	0.0061	1

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.52	gold quality
upper arm skin	UBERON:0004263	65.40	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	58.25	gold quality
lower lobe of lung	UBERON:0008949	56.00	silver quality
nasal cavity epithelium	UBERON:0005384	55.52	gold quality
cardiac muscle of right atrium	UBERON:0003379	55.41	gold quality
mucosa of paranasal sinus	UBERON:0005030	54.60	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
epithelial cell of pancreas	CL:0000083	53.75	gold quality
buccal mucosa cell	CL:0002336	53.25	gold quality
pancreatic ductal cell	CL:0002079	52.57	silver quality
sural nerve	UBERON:0015488	52.16	gold quality
quadriceps femoris	UBERON:0001377	50.70	gold quality
myocardium	UBERON:0002349	50.70	gold quality
vastus lateralis	UBERON:0001379	50.20	gold quality
deltoid	UBERON:0001476	49.05	gold quality
stromal cell of endometrium	CL:0002255	48.26	gold quality
tibialis anterior	UBERON:0001385	45.59	silver quality
ileal mucosa	UBERON:0000331	45.15	silver quality
layer of synovial tissue	UBERON:0007616	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
substantia nigra pars reticulata	UBERON:0001966	43.09	gold quality
pituitary gland	UBERON:0000007	43.03	gold quality
muscle tissue	UBERON:0002385	43.03	gold quality
testis	UBERON:0000473	42.97	gold quality
right testis	UBERON:0004534	42.85	gold quality
skeletal muscle tissue	UBERON:0001134	42.58	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
epithelium of nasopharynx	UBERON:0001951	42.36	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

4 targets.

Target	Regulation
CD34
RHO	Unknown
TRAF1
XRN1

Literature-anchored findings (GeneRIF, showing 3)

• no indications were found for an association between the MBX gene and microphthalmia with congenital cataract in humans (PMID:17990594)
• Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. (PMID:27980695)
• Authors found that the function of DMBX1 was dependent on p21 (CDKN1A), a key regulator of G1/S cell cycle progression. Co-IP assay revealed that DMBX1 directly bound to another homeobox transcription factor, OTX2. ChIP and luciferase reporter assay confirmed that OTX2 directly interacted with the promoter region of p21 to enhance its transcription, and DMBX1 repressed OTX2-mediated transcription of p21. (PMID:30928384)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dmbx1b	ENSDARG00000002510
danio_rerio	dmbx1a	ENSDARG00000009922
mus_musculus	Dmbx1	ENSMUSG00000028707
rattus_norvegicus	Dmbx1	ENSRNOG00000010835

Paralogs (50): ARX (ENSG00000004848), PAX6 (ENSG00000007372), PAX7 (ENSG00000009709), ALX4 (ENSG00000052850), GSC2 (ENSG00000063515), PITX1 (ENSG00000069011), PAX2 (ENSG00000075891), RHOXF1 (ENSG00000101883), CRX (ENSG00000105392), EVX1 (ENSG00000106038), PAX4 (ENSG00000106331), NOBOX (ENSG00000106410), PITX3 (ENSG00000107859), PHOX2B (ENSG00000109132), OTX1 (ENSG00000115507), PRRX1 (ENSG00000116132), VSX2 (ENSG00000119614), ESX1 (ENSG00000123576), PAX8 (ENSG00000125618), PAX1 (ENSG00000125813), RHOXF2 (ENSG00000131721), GSC (ENSG00000133937), RAX (ENSG00000134438), PAX3 (ENSG00000135903), ALX3 (ENSG00000156150), HESX1 (ENSG00000163666), PITX2 (ENSG00000164093), UNCX (ENSG00000164853), PHOX2A (ENSG00000165462), OTX2 (ENSG00000165588), DRGX (ENSG00000165606), PRRX2 (ENSG00000167157), SHOX2 (ENSG00000168779), OTP (ENSG00000171540), RAX2 (ENSG00000173976), EVX2 (ENSG00000174279), PROP1 (ENSG00000175325), ISX (ENSG00000175329), ALX1 (ENSG00000180318), MIXL1 (ENSG00000185155)

Protein

Protein identifiers

Diencephalon/mesencephalon homeobox protein 1 — Q8NFW5 (reviewed: Q8NFW5)

Alternative names: Orthodenticle homolog 3, Paired-like homeobox protein DMBX1

All UniProt accessions (1): Q8NFW5

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development.

Subunit / interactions. Homodimer or heterodimer. Forms heterodimers with OTX2.

Subcellular location. Nucleus.

Similarity. Belongs to the paired homeobox family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8NFW5-1	1, MBX-L	yes
Q8NFW5-2	2, MBX-S

RefSeq proteins (4): NP_001374704, NP_001374705, NP_671725, NP_757379* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR003654	OAR_dom	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR052488	DMBX_homeobox	Family

Pfam: PF00046, PF03826

UniProt features (12 total): compositionally biased region 3, sequence variant 2, region of interest 2, chain 1, DNA-binding region 1, sequence conflict 1, short sequence motif 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NFW5-F1	63.71	0.16

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 86 (showing top): GOBP_BEHAVIOR, GOBP_ADULT_BEHAVIOR, GOBP_GROWTH, GOBP_ADULT_LOCOMOTORY_BEHAVIOR, GOBP_HEAD_DEVELOPMENT, GOCC_TRANSCRIPTION_REGULATOR_COMPLEX, GOBP_FEEDING_BEHAVIOR, GOBP_DEVELOPMENTAL_GROWTH, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MEISSNER_BRAIN_HCP_WITH_H3K27ME3, MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, MIKKELSEN_NPC_HCP_WITH_H3K27ME3, MIKKELSEN_MEF_HCP_WITH_H3K27ME3, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II

GO Biological Process (9): regulation of transcription by RNA polymerase II (GO:0006357), central nervous system development (GO:0007417), brain development (GO:0007420), adult feeding behavior (GO:0008343), adult locomotory behavior (GO:0008344), negative regulation of DNA-templated transcription (GO:0045892), developmental growth (GO:0048589), negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (8): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), identical protein binding (GO:0042802), sequence-specific DNA binding (GO:0043565), sequence-specific double-stranded DNA binding (GO:1990837)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), transcription regulator complex (GO:0005667)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	3
transcription by RNA polymerase II	2
adult behavior	2
DNA-templated transcription	2
regulation of transcription by RNA polymerase II	2
transcription cis-regulatory region binding	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
nervous system development	1
system development	1
central nervous system development	1
animal organ development	1
head development	1
feeding behavior	1
locomotory behavior	1
negative regulation of RNA biosynthetic process	1
developmental process	1
growth	1
negative regulation of DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
nucleic acid binding	1
transcription regulator activity	1
protein binding	1
DNA binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

674 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DMBX1	AGRP	O00253	627
DMBX1	OTX2	P32243	590
DMBX1	RAB2A	P08886	483
DMBX1	SIK3	Q9Y2K2	440
DMBX1	PAX2	Q02962	434
DMBX1	HOMEZ	Q8IX15	419
DMBX1	SIX3	O95343	396
DMBX1	FERRY3	Q9NQ89	350
DMBX1	FADS6	Q8N9I5	349
DMBX1	EFCAB14	O75071	348
DMBX1	LURAP1	Q96LR2	346
DMBX1	FOXB1	Q99853	343
DMBX1	ZIC1	Q15915	340
DMBX1	SOX8	P57073	325
DMBX1	OTX1	P32242	319

IntAct

2 interactions, top by confidence:

A	B	Type	Score
DMBX1	NUMA1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (2): DMBX1 (Proximity Label-MS), DMBX1 (Reconstituted Complex)

ESM2 similar proteins: A0JPN1, A6NHT5, A6YP92, A7MB54, M0R6D8, O02786, O35085, O35762, O42230, O57601, O88181, O95096, P09065, P13297, P28360, P42581, P43697, P50219, P52955, P70390, P78414, P78415, P79772, P81067, P81068, Q05925, Q0P4W6, Q14549, Q14774, Q1XID0, Q2VL76, Q2VL77, Q2VL78, Q2VL79, Q2VL80, Q2VL82, Q2VL83, Q2VL84, Q2VL85, Q2VL86

Diamond homologs: A1A546, A1YEV8, A1YEY5, A1YFI3, A1YG25, A1YG57, A1YGA2, A2T711, A2T733, A2T777, A2T7P4, A6NNA5, A6YP92, F1NEA7, G5EC89, O14813, O15499, O35085, O35137, O35690, O42115, O42201, O42250, O42356, O42357, O42567, O43186, O54751, O70137, O73917, O95076, O97039, P0DMV5, P23759, P23760, P24610, P26367, P26630, P29454, P32242

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	53
Likely benign	6
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
183286	NM_172225.2(DMBX1):c.352C>T (p.Arg118Trp)	Likely pathogenic

SpliceAI

650 predictions. Top by Δscore:

Variant	Effect	Δscore
1:46507160:GGCTG:G	donor_gain	1.0000
1:46507161:GCTG:G	donor_gain	1.0000
1:46507161:GCTGG:G	donor_gain	1.0000
1:46507162:CTGG:C	donor_loss	1.0000
1:46507163:TGG:T	donor_loss	1.0000
1:46507164:GGTAA:G	donor_loss	1.0000
1:46507165:G:C	donor_loss	1.0000
1:46507165:G:GG	donor_gain	1.0000
1:46507166:T:A	donor_loss	1.0000
1:46510457:A:AG	acceptor_gain	1.0000
1:46510458:A:G	acceptor_gain	1.0000
1:46510459:C:G	acceptor_gain	1.0000
1:46510650:TGCAG:T	donor_loss	1.0000
1:46510653:AGGT:A	donor_loss	1.0000
1:46510654:GGT:G	donor_loss	1.0000
1:46510655:GTAGG:G	donor_loss	1.0000
1:46510656:T:A	donor_loss	1.0000
1:46510934:GGT:G	acceptor_gain	1.0000
1:46511013:G:GT	donor_gain	1.0000
1:46507149:GC:G	donor_gain	0.9900
1:46507150:C:G	donor_gain	0.9900
1:46507162:CTG:C	donor_gain	0.9900
1:46507163:TG:T	donor_gain	0.9900
1:46507164:GG:G	donor_gain	0.9900
1:46510449:T:A	acceptor_gain	0.9900
1:46510457:AAC:A	acceptor_gain	0.9900
1:46510457:AACG:A	acceptor_gain	0.9900
1:46510458:AC:A	acceptor_gain	0.9900
1:46510458:ACG:A	acceptor_gain	0.9900
1:46510459:C:CA	acceptor_gain	0.9900

AlphaMissense

2420 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:46510520:C:A	R72S	1.000
1:46510520:C:T	R72C	1.000
1:46510523:C:A	R73S	1.000
1:46510523:C:T	R73C	1.000
1:46510526:A:C	S74R	1.000
1:46510528:C:A	S74R	1.000
1:46510528:C:G	S74R	1.000
1:46510529:C:A	R75S	1.000
1:46510529:C:G	R75G	1.000
1:46510529:C:T	R75C	1.000
1:46510530:G:A	R75H	1.000
1:46510530:G:T	R75L	1.000
1:46510532:A:T	T76S	1.000
1:46510533:C:A	T76K	1.000
1:46510533:C:T	T76I	1.000
1:46510536:C:A	A77E	1.000
1:46510538:T:A	F78I	1.000
1:46510538:T:C	F78L	1.000
1:46510538:T:G	F78V	1.000
1:46510539:T:C	F78S	1.000
1:46510539:T:G	F78C	1.000
1:46510540:C:A	F78L	1.000
1:46510540:C:G	F78L	1.000
1:46510551:A:G	Q82R	1.000
1:46510552:G:C	Q82H	1.000
1:46510552:G:T	Q82H	1.000
1:46510553:C:T	L83F	1.000
1:46510554:T:A	L83H	1.000
1:46510554:T:C	L83P	1.000
1:46510559:G:C	A85P	1.000

dbSNP variants (sampled 300 via entrez): RS1000010390 (1:46505855 GC>G), RS1000084457 (1:46512073 T>G), RS1000095609 (1:46488364 G>A,C), RS1000130562 (1:46491183 C>G), RS1000164464 (1:46497920 G>A,T), RS1000250656 (1:46506193 A>C,G), RS1000288664 (1:46499694 C>T), RS1000414180 (1:46499496 T>C), RS1000538156 (1:46512232 C>T), RS1000640971 (1:46498172 C>A), RS1000735939 (1:46492404 A>C), RS1000746771 (1:46497902 G>T), RS1000802026 (1:46493498 G>C), RS1000911712 (1:46516309 C>G), RS1000971459 (1:46504032 A>C,G)

Disease associations

OMIM: gene MIM:607410 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
complex neurodevelopmental disorder	Limited	Autosomal recessive

Mondo (4): strabismus (MONDO:0003432), hyperopia (MONDO:0004891), hearing loss disorder (MONDO:0005365), complex neurodevelopmental disorder (MONDO:0100038)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002828_25	Urate levels in obese individuals	4.000000e-06
GCST003996_24	Monobrow	4.000000e-09
GCST004751_9	Serum uric acid levels in response to allopurinol in gout	2.000000e-06
GCST005951_37	Body mass index	8.000000e-10

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0007906	synophrys measurement
EFO:0004761	uric acid measurement
EFO:0004340	body mass index

MeSH disease descriptors (3)

Descriptor	Name	Tree numbers
D034381	Hearing Loss	C09.218.458.341; C10.597.751.418.341; C23.888.592.763.393.341
D006956	Hyperopia	C11.744.479
D013285	Strabismus	C10.292.562.887; C11.590.810

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
bisphenol A	decreases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
sodium arsenite	increases expression	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Troglitazone	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Pesticides	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
Testosterone	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

302 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00461656	PHASE4	COMPLETED	Povidone-iodine Antisepsis for Strabismus Surgery
NCT01901588	PHASE4	COMPLETED	Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery
NCT02379546	PHASE4	COMPLETED	The Effect of Anaesthesia Depth on Oculo-cardiac Reflex
NCT03349515	PHASE4	COMPLETED	The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia.
NCT04549844	PHASE4	UNKNOWN	Peribulbar Block for Prevention of Oculocardiac Reflex
NCT06035757	PHASE4	RECRUITING	The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery
NCT06560268	PHASE4	NOT_YET_RECRUITING	Low Flow Anesthesia in Children Undergoing Strabismus Surgery
NCT00347204	PHASE4	COMPLETED	Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK
NCT00455455	PHASE4	COMPLETED	Corneal and Conjunctival Sensitivity and Staining Study
NCT00937105	PHASE4	COMPLETED	Daily Wear Corneal Infiltrative Event Study
NCT01387360	PHASE4	COMPLETED	Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes
NCT01977807	PHASE4	UNKNOWN	A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK
NCT02071576	PHASE4	UNKNOWN	A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIK
NCT02112968	PHASE4	UNKNOWN	A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia
NCT03881670	PHASE4	COMPLETED	On-Eye Optical Quality of Lotrafilcon B Lenses Over 12 Hours
NCT04208750	PHASE4	COMPLETED	Clinical Investigation of the Vision-R800 Device.
NCT04283331	PHASE4	UNKNOWN	Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK)
NCT00205881	PHASE4	COMPLETED	Bilateral Benefit in Adult Users of the HiRes 90K Bionic Ear System
NCT00331539	PHASE4	UNKNOWN	Relationship Between Auto NRT and Behavioural T & C Levels With the Nucleus Freedom Cochlear Implant
NCT00424307	PHASE4	UNKNOWN	Bilateral Cochlear Implant Benefit in Young Children
NCT00765635	PHASE4	COMPLETED	Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal
NCT03321006	PHASE4	COMPLETED	Treating Hearing Loss to Improve Mood and Cognition in Older Adults
NCT00000128	PHASE3	UNKNOWN	A Trial of Bifocals in Myopic Children With Esophoria
NCT00001864	PHASE3	COMPLETED	Amblyopia (Lazy Eye) Treatment Study
NCT00038753	PHASE3	UNKNOWN	Vision In Preschoolers Study (VIP Study)
NCT01584843	PHASE3	COMPLETED	Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Patients With Strabismus
NCT04060771	PHASE3	UNKNOWN	Post-Operative Nausea and Vomiting in Children Submitted to Strabismus Surgery
NCT06863675	PHASE3	NOT_YET_RECRUITING	Highly Aspherical Lenslet (HAL) and Binocular Vision (BV) Disorders [HALT X(T) Study]
NCT00520689	PHASE3	COMPLETED	Multipurpose Disinfecting Solution Compatibility With a Silicone Hydrogel Contact Lens
NCT00910403	PHASE3	COMPLETED	Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes
NCT00928122	PHASE3	UNKNOWN	Intrastromal Correction of Ametropia by a Femtosecond Laser
NCT01028378	PHASE3	COMPLETED	Safety and Efficacy Study of Topography-Guided LASIK to Treat Myopia and Hyperopia
NCT01322919	PHASE3	COMPLETED	Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure
NCT05247658	PHASE3	TERMINATED	Use of a Disk of Amniotic Membrane (Visio-AMTRIX) in Postoperative Care After PKR
NCT01499901	PHASE3	WITHDRAWN	Comparison of the Bilateral Sequential and Simultaneous Cochlear Implantation in the Deaf Children
NCT02561091	PHASE3	COMPLETED	AM-111 in the Treatment of Acute Inner Ear Hearing Loss
NCT03331627	PHASE3	COMPLETED	Safety and Efficacy of STR001-IT and STR001-ER in Patients With SSHL
NCT05532657	PHASE3	ACTIVE_NOT_RECRUITING	ACHIEVE Brain Health Follow-Up Study
NCT00478907	PHASE2	COMPLETED	Prevention of Complications of Eye Surgery
NCT06689943	PHASE2	NOT_YET_RECRUITING	Pain After Strabismus Surgery