DMRT2

Summary

DMRT2 (doublesex and mab-3 related transcription factor 2, HGNC:2935) is a protein-coding gene on chromosome 9p24.3, encoding Doublesex- and mab-3-related transcription factor 2 (Q9Y5R5). Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it.

The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila ‘doublesex’ (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9.

Source: NCBI Gene 10655 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spondylocostal dysostosis (Limited, GenCC)
• GWAS associations: 20
• Clinical variants (ClinVar): 256 total — 2 pathogenic, 1 likely-pathogenic
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence
• MANE Select transcript: NM_181872

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2935
Approved symbol	DMRT2
Name	doublesex and mab-3 related transcription factor 2
Location	9p24.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000173253
Ensembl biotype	protein_coding
OMIM	604935
Entrez	10655

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 10 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000259622, ENST00000302441, ENST00000358146, ENST00000382251, ENST00000382255, ENST00000412350, ENST00000634526, ENST00000634824, ENST00000635183, ENST00000910808, ENST00000910809, ENST00000910810

RefSeq mRNA: 10 — MANE Select: NM_181872 NM_001130865, NM_001370531, NM_001370532, NM_001370533, NM_001387557, NM_001387558, NM_001387559, NM_001387560, NM_006557, NM_181872

CCDS: CCDS6444, CCDS6445

Canonical transcript exons

ENST00000358146 — 4 exons

Exon	Start	End
ENSE00000927829	1051570	1052138
ENSE00001203046	1053722	1053824
ENSE00001409172	1056216	1057552
ENSE00003916665	1050357	1050775

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 92.78.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2239 / max 84.4928, expressed in 372 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95819	1.0861	347
95821	0.0578	33
95822	0.0407	14
95820	0.0392	17

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	92.78	gold quality
metanephros cortex	UBERON:0010533	91.78	gold quality
adult mammalian kidney	UBERON:0000082	89.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.33	gold quality
biceps brachii	UBERON:0001507	84.62	silver quality
buccal mucosa cell	CL:0002336	83.21	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	82.48	silver quality
kidney	UBERON:0002113	82.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.39	gold quality
quadriceps femoris	UBERON:0001377	79.32	silver quality
cortex of kidney	UBERON:0001225	78.72	gold quality
mucosa of transverse colon	UBERON:0004991	76.53	gold quality
nasal cavity mucosa	UBERON:0001826	75.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.66	gold quality
skeletal muscle tissue	UBERON:0001134	74.42	gold quality
metanephros	UBERON:0000081	73.54	gold quality
mucosa of paranasal sinus	UBERON:0005030	72.39	gold quality
muscle of leg	UBERON:0001383	72.19	gold quality
gastrocnemius	UBERON:0001388	71.24	gold quality
adipose tissue	UBERON:0001013	70.58	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.06	gold quality
renal medulla	UBERON:0000362	70.02	gold quality
muscle tissue	UBERON:0002385	69.96	gold quality
thymus	UBERON:0002370	69.86	gold quality
apex of heart	UBERON:0002098	69.59	gold quality
deltoid	UBERON:0001476	69.43	silver quality
endothelial cell	CL:0000115	68.22	silver quality
spinal cord	UBERON:0002240	67.85	gold quality
bronchial epithelial cell	CL:0002328	67.73	gold quality
sural nerve	UBERON:0015488	67.61	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	39.28
E-CURD-114	yes	12.05
E-ANND-3	yes	6.42

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

151 targeting DMRT2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-557	99.96	70.01	1640

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 6)

• Evidence for the essential function of HSF1 in the transcriptional activation of TERRA and in telomere protection upon stress. (PMID:28369628)
• This study showed that 18p TERRA expression was marginally significantly associated with preoperative CEA and significantly associated with telomere length, rendering it a potential prognostic factor for long-term oncologic outcomes in CRC. (PMID:30946316)
• study confirms that TERRA corresponds to a large gene family transcribed from multiple chromosome ends where we identified two types of TERRA promoters, only one of which is regulated by DNA methylation (PMID:31350341)
• Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells. (PMID:31846834)
• TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication. (PMID:33082515)
• Protein Phosphatase 2A-Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping. (PMID:34933911)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	dmrt2a	ENSDARG00000015072
mus_musculus	Dmrt2	ENSMUSG00000048138
rattus_norvegicus	Dmrt2	ENSRNOG00000016301
drosophila_melanogaster	dmrt11E	FBGN0030477
caenorhabditis_elegans		WBGENE00019521
caenorhabditis_elegans		WBGENE00022060

Paralogs (8): DMRT3 (ENSG00000064218), DMRT1 (ENSG00000137090), DMRTC2 (ENSG00000142025), DMRTA2 (ENSG00000142700), DMRTB1 (ENSG00000143006), DMRTA1 (ENSG00000176399), DMRTC1B (ENSG00000184911), DMRTC1 (ENSG00000269502)

Protein

Protein identifiers

Doublesex- and mab-3-related transcription factor 2 — Q9Y5R5 (reviewed: Q9Y5R5)

Alternative names: Doublesex-like 2 protein

All UniProt accessions (3): Q9Y5R5, A0A0A0MR18, Q05C20

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome.

Subunit / interactions. Homodimer.

Subcellular location. Nucleus.

Tissue specificity. Expressed in testis, kidney and skeletal muscle.

Miscellaneous. Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224. Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224.

Similarity. Belongs to the DMRT family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y5R5-1	1	yes
Q9Y5R5-2	2
Q9Y5R5-3	3

RefSeq proteins (9): NP_001124337, NP_001357460, NP_001357461, NP_001357462, NP_001374486, NP_001374487, NP_001374488, NP_006548, NP_870987* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001275	DM_DNA-bd	Domain
IPR026607	DMRT	Family
IPR036407	DM_DNA-bd_sf	Homologous_superfamily

Pfam: PF00751

UniProt features (15 total): compositionally biased region 4, splice variant 3, sequence variant 2, sequence conflict 2, region of interest 2, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5R5-F1	54.37	0.10

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 123 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, AAGCAAT_MIR137, GOBP_EPITHELIUM_DEVELOPMENT, BENPORATH_ES_WITH_H3K27ME3, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT, TGACCTY_ERR1_Q2, TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN, ATGCAGT_MIR217, ATGTTAA_MIR302C, GOBP_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION, GOBP_SOMITOGENESIS, TCCCCAC_MIR491

GO Biological Process (8): regulation of transcription by RNA polymerase II (GO:0006357), sex differentiation (GO:0007548), regulation of somitogenesis (GO:0014807), embryonic skeletal system development (GO:0048706), myotome development (GO:0061055), positive regulation of myotome development (GO:2000287), regulation of DNA-templated transcription (GO:0006355), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (9): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), identical protein binding (GO:0042802), metal ion binding (GO:0046872), RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA binding (GO:0003677), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
cellular anatomical structure	2
regulation of DNA-templated transcription	1
developmental process involved in reproduction	1
somitogenesis	1
regulation of anatomical structure morphogenesis	1
regulation of multicellular organismal process	1
skeletal system development	1
chordate embryonic development	1
anatomical structure development	1
somite development	1
positive regulation of developmental process	1
myotome development	1
regulation of myotome development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
protein binding	1
cation binding	1
transcription cis-regulatory region binding	1
nucleic acid binding	1
binding	1
DNA binding	1
chromosome	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

960 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DMRT2	SRY	Q05066	803
DMRT2	DMRT3	Q9NQL9	534
DMRT2	ZFY	P08048	505
DMRT2	KANK1	Q14678	494
DMRT2	FOXL2	P58012	483
DMRT2	HNRNPUL2	Q1KMD3	477
DMRT2	ASB18	Q6ZVZ8	452
DMRT2	NR0B1	P51843	450
DMRT2	FOXL3	A0A1W2PRP0	432
DMRT2	AMH	P03971	415
DMRT2	RPL7	P18124	413
DMRT2	ACTB	P02570	409
DMRT2	WNT4	P56705	408
DMRT2	MYF5	P13349	405
DMRT2	PDLIM7	Q9NR12	395
DMRT2	SOX3	P35714	395

IntAct

6 interactions, top by confidence:

A	B	Type	Score
TLE5	DMRT2	psi-mi:“MI:0915”(physical association)	0.560
DMRT2	MAGED1	psi-mi:“MI:0915”(physical association)	0.560
DMRT2	TLE5	psi-mi:“MI:0915”(physical association)	0.000
DMRT2	MAGED1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (3): DMRT2 (Reconstituted Complex), DMRT2 (Two-hybrid), MAGED1 (Two-hybrid)

ESM2 similar proteins: A2A9I7, A7X8C7, A7X8C9, A7XW16, C7EMF5, F6W2R2, O15054, O43151, O43474, O55087, O62651, O94993, P08151, P0DPQ3, P10284, P17483, P31259, P31276, P47806, P52947, P86478, P86479, P86480, P86481, P86496, Q00175, Q08DG5, Q0P670, Q1KKY2, Q5NCY0, Q5ND04, Q5SSZ7, Q60793, Q63449, Q6NZN1, Q6XP49, Q801F8, Q80WT2, Q8BG36, Q8BG87

Diamond homologs: A2A9A2, A2A9I7, A4QNP7, A6QQ94, A8TSS9, B0I1G7, B7ZS42, C0LZJ1, D4A218, F6W2R2, G5EEJ1, J7FCF0, O18214, P23023, P57690, P83758, P85119, Q18248, Q19291, Q2I327, Q2MJB4, Q32LE6, Q3LH63, Q4AE28, Q5UU75, Q5VZB9, Q6YHU8, Q71MM5, Q76L87, Q801F8, Q80WT2, Q8BG36, Q8CFG4, Q8CGW9, Q8IXT2, Q8JIR6, Q90WM5, Q96MA1, Q96SC8, Q9DFI0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

256 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	1
Uncertain significance	185
Likely benign	53
Benign	8

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
253670	GRCh37/hg19 9p24.3-22.1(chr9:213161-19450250)x3	Pathogenic
638656	NM_181872.6(DMRT2):c.1A>T (p.Met1Leu)	Pathogenic
3900977	NM_181872.6(DMRT2):c.129del (p.Asp43fs)	Likely pathogenic

SpliceAI

803 predictions. Top by Δscore:

Variant	Effect	Δscore
9:1053717:TACAG:T	acceptor_loss	1.0000
9:1053719:CAGG:C	acceptor_loss	1.0000
9:1053720:A:AG	acceptor_gain	1.0000
9:1053721:G:GG	acceptor_gain	1.0000
9:1053721:G:GT	acceptor_loss	1.0000
9:1052137:AGG:A	donor_loss	0.9900
9:1052138:GGT:G	donor_loss	0.9900
9:1052140:T:G	donor_loss	0.9900
9:1053720:AG:A	acceptor_gain	0.9900
9:1053721:GG:G	acceptor_gain	0.9900
9:1053823:AGGT:A	donor_loss	0.9900
9:1053824:GGTAA:G	donor_loss	0.9900
9:1053825:G:A	donor_loss	0.9900
9:1053826:T:G	donor_loss	0.9900
9:1055217:A:AG	acceptor_gain	0.9900
9:1055217:AAAT:A	acceptor_gain	0.9900
9:1055218:A:G	acceptor_gain	0.9900
9:1056045:G:GT	donor_gain	0.9900
9:1056046:A:T	donor_gain	0.9900
9:1050479:CAAG:C	donor_loss	0.9800
9:1050480:AAGGT:A	donor_loss	0.9800
9:1050481:AG:A	donor_loss	0.9800
9:1050482:GG:G	donor_loss	0.9800
9:1050483:GTG:G	donor_loss	0.9800
9:1050484:T:G	donor_loss	0.9800
9:1050543:GC:G	donor_gain	0.9800
9:1051569:GA:G	acceptor_gain	0.9800
9:1052136:GAG:G	donor_gain	0.9800
9:1052139:G:GG	donor_gain	0.9800
9:1053782:C:T	donor_gain	0.9800

AlphaMissense

3654 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:1051980:T:A	C123S	1.000
9:1051980:T:C	C123R	1.000
9:1051981:G:C	C123S	1.000
9:1051982:C:G	C123W	1.000
9:1051986:C:A	R125S	1.000
9:1051989:T:A	C126S	1.000
9:1051989:T:C	C126R	1.000
9:1051990:G:A	C126Y	1.000
9:1051990:G:C	C126S	1.000
9:1051991:C:G	C126W	1.000
9:1051992:C:A	R127S	1.000
9:1051995:A:G	N128D	1.000
9:1051997:C:A	N128K	1.000
9:1051997:C:G	N128K	1.000
9:1051998:C:A	H129N	1.000
9:1051998:C:G	H129D	1.000
9:1052000:C:A	H129Q	1.000
9:1052000:C:G	H129Q	1.000
9:1052002:G:A	G130D	1.000
9:1052021:G:C	K136N	1.000
9:1052021:G:T	K136N	1.000
9:1052025:C:G	H138D	1.000
9:1052027:C:A	H138Q	1.000
9:1052027:C:G	H138Q	1.000
9:1052028:A:G	K139E	1.000
9:1052029:A:T	K139M	1.000
9:1052030:G:C	K139N	1.000
9:1052030:G:T	K139N	1.000
9:1052037:T:A	C142S	1.000
9:1052037:T:C	C142R	1.000

dbSNP variants (sampled 300 via entrez): RS1000029198 (9:1052153 G>A,C,T), RS1000232486 (9:1054648 A>G), RS1000277493 (9:1054487 T>C), RS1000395121 (9:1050531 G>C), RS1000556180 (9:1055878 T>A), RS1000628015 (9:1054674 C>A,T), RS1000703162 (9:1050362 C>A,G), RS1001018184 (9:1051642 C>A,T), RS1001623190 (9:1050073 C>G), RS1001671357 (9:1055276 C>G), RS1002011041 (9:1054087 A>T), RS1002054081 (9:1056155 T>C,G), RS1002253152 (9:1051934 C>A,G,T), RS1002824345 (9:1048429 C>A,G,T), RS1002858603 (9:1049447 C>A)

Disease associations

OMIM: gene MIM:604935 | disease phenotypes: MIM:600171, MIM:621523

GenCC curated gene-disease

Disease	Classification	Inheritance
spondylocostal dysostosis	Limited	Autosomal recessive

Mondo (3): gonadal agenesis (MONDO:0010838), spondylocostal dysostosis 7, autosomal recessive (MONDO:0981023), spondylocostal dysostosis (MONDO:0000359)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

20 associations (top):

Study	Trait	p-value
GCST000278_8	Hyperactive-impulsive symptoms	5.000000e-06
GCST001144_7	Dupuytren’s disease	6.000000e-09
GCST003059_15	Parkinson’s disease	1.000000e-06
GCST003542_195	Night sleep phenotypes	4.000000e-06
GCST003542_8	Night sleep phenotypes	3.000000e-08
GCST003996_2	Monobrow	4.000000e-62
GCST003999_7	Nose size	1.000000e-09
GCST004858_13	Dupuytren’s disease	4.000000e-26
GCST006152_2	Language impairment in frontotemporal lobe dementia	6.000000e-06
GCST006481_17	Lung function (FEV1)	5.000000e-08
GCST006481_41	Lung function (FEV1)	5.000000e-06
GCST006483_64	Lung function (FVC)	3.000000e-08
GCST006483_65	Lung function (FVC)	1.000000e-07
GCST006483_68	Lung function (FVC)	7.000000e-09
GCST010118_170	Type 2 diabetes	2.000000e-08
GCST010173_135	Triglyceride levels	9.000000e-09
GCST010242_185	HDL cholesterol levels	5.000000e-08
GCST010244_299	Triglyceride levels	3.000000e-12
GCST90002385_375	High light scatter reticulocyte count	3.000000e-10
GCST90002386_420	High light scatter reticulocyte percentage of red cells	2.000000e-09

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004229	Dupuytren Contracture
EFO:0007906	synophrys measurement
EFO:0004314	forced expiratory volume
EFO:0004312	vital capacity
EFO:0004530	triglyceride measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0007986	reticulocyte count

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C537565	Jarcho-Levin syndrome (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	3
tungsten carbide	affects binding, decreases expression	1
terbufos	increases methylation	1
arsenite	increases methylation	1
cobaltous chloride	decreases expression	1
butyraldehyde	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
15-acetyldeoxynivalenol	increases expression	1
monomethylarsonous acid	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Cobalt	affects binding, decreases expression	1
Fonofos	increases methylation	1
Lipopolysaccharides	increases expression, affects cotreatment, decreases expression, affects response to substance	1
Parathion	increases methylation	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	decreases methylation	1
Antirheumatic Agents	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A0Z8	SEES3-1V human DMRT2, clone1	Embryonic stem cell	Male
CVCL_A0Z9	SEES3-1V human DMRT2, clone2	Embryonic stem cell	Male
CVCL_A1A0	SEES3-1V human DMRT2, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.